ISOCYANOBENZENE
- CAS No.
- 931-54-4
- Chemical Name:
- ISOCYANOBENZENE
- Synonyms
- Benzoisonitrile;ISOCYANOBENZENE;PHENYLISOCYANIDE;1-ISOCYANOBENZENE;Phenyl isonitrile;Phenyl carbylamine;Benzene, isocyano-;PHENYL ISOCYANIDE (1-ISOCYANOBENZENE)
- CBNumber:
- CB3382268
- Molecular Formula:
- C7H5N
- Molecular Weight:
- 103.12
- MDL Number:
- MFCD05148520
- MOL File:
- 931-54-4.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H331-H301-H311 |
| Precautionary statements | P280-P302+P352-P312-P322-P361-P363-P405-P501-P261-P271-P304+P340-P311-P321-P403+P233-P405-P501-P264-P270-P301+P310-P321-P330-P405-P501 |
| Risk Statements | 20/21/22 |
| Safety Statements | 26-36/37/39 |
| RIDADR | UN 1672 6.1/ PGI |
| HazardClass | 6.1 |
| PackingGroup | I |
ISOCYANOBENZENE price More Price(3)
ISOCYANOBENZENE Chemical Properties,Uses,Production
Uses
Isocyanobenzene is used in the study of the inhibition mechanism of reconstituted cytochrome p-450scc-linked monooxygenase system by antimycotic reagent and other inhibitors.
Preparation
To a flask containing 7.9 gm (0.33 mole) of sodium hydride in 100 ml of tetrahydrofuran is slowly added a mixture of 9.3 gm (0.1 mole) of aniline and 25.3 gm (0.10 mole) of bromoform. After the addition, the reaction is stirred for 1-2 hr at room temperature, and water is added (100 ml) dropwise. Ether (200 ml) is added and the ether layer washed four times with 50-ml portions of water, three times with 20-ml portions of dilute hydrochloric acid, and then with water. The resulting ether layer is dried over sodium sulfate, concentrated, and the residue distilled to afford 4.7 gm (45%), b.p. 52-53°C (13 mm Hg).
Definition
ChEBI: Phenyl isocyanide is an isocyanide.
Precautions
Should be used freshly distilled. Foul smelling liquid; should be stored and used in a fume hood. Contaminated equipment should be washed with 5% methanolic sulfuric acid.
References
1. For general reviews on isocyanide chemistry, see: (a) Isonitrile Chemistry; Ugi, I., Ed.; Academic: New York, 1971. (b) Periasamy, M. P.; Walborsky, H. M. OPP 1979, 11, 295.
2. For applications in heterocyclic synthesis, see: Marcaccini, S.; Torroba, T. OPP 1993, 25, 141.
3. (a) Grundmann, C. CB 1958, 91, 1380. (b) Ugi, I.; Meyr, R. OS 1961, 41, 101. (c) Obrecht, R.; Herrmann, R.; Ugi, I. S 1985, 400.
4. Figueroa-Villar, J. D.; Carnieiro, C. L.; Cruz, E. R. H 1992, 34, 891
ISOCYANOBENZENE Preparation Products And Raw materials
Raw materials
Preparation Products
ISOCYANOBENZENE Suppliers
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