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ChemicalBook >> CAS DataBase List >>3,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE

3,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE

3,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE Structure
3,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE structure
CAS No.
552-54-5
Chemical Name:
3,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE
Synonyms
C.I.75700;RhaMnacine;NSC 678106;rhamnacene;RHAMNAZIN(SH);3,7-DIMETHYLQUERCETIN;7,3'-DiMethylquercetin;3',7-Di-O-Methylquercetin;7,3'-Di-O-methylquercetin;QUERCETIN-3,7-DIMETHYL ETHER
CBNumber:
CB3409525
Molecular Formula:
C17H14O7
Molecular Weight:
330.29
MDL Number:
MFCD00017426
MOL File:
552-54-5.mol
Last updated:2025-04-17 18:22:24
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3,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE Properties

Melting point 214-215 °C
Boiling point 591.6±50.0 °C(Predicted)
Density 1.507±0.06 g/cm3(Predicted)
pka 6.14±0.40(Predicted)
form powder
BRN 338203
FDA UNII 276CK9GP9Y
UNSPSC Code 12352205
NACRES NA.25

SAFETY

Risk and Safety Statements

WGK Germany  3

3,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 93815 Rhamnazin ≥99% (HPLC) 552-54-5 5mg $423 2024-03-01 Buy
TRC D479175 3’,7-Di-O-methylQuercetin 552-54-5 50mg $1540 2021-12-16 Buy
Product number Packaging Price Buy
93815 5mg $423 Buy
D479175 50mg $1540 Buy

3,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE Chemical Properties,Uses,Production

Uses

Di-O-methylated flavanol; a polyphenolic metabolite of Rhamnus disperma.

Definition

ChEBI: A dimethoxyflavone that is quercetin in which the hydroxy groups at the 3' and 7 positions have been replaced by methoxy groups.

in vivo

Rhamnazin (200 mg/kg; i.g.; daily for 25 days) inhibits breast cancer growth and angiogenesis in mice[1].
Rhamnazin (5-20 mg/kg; i.p.; once) shows strong antioxidant and anti-inflammatory properties in the rat acute lung injury model[2].

Animal Model:BALB/c nude mice, breast cancer xenograft model[1]
Dosage:200 mg/kg
Administration:Intragastric administration, daily for 25 days
Result:Dramatically suppressed tumor volumes by 47% compared with the vehicle group. Showed a significant reduction of pVEGFR2Tyr951-positive cells in tumors. Resulted in downregulation of VEGFR2 downstream molecules phosphorylation including MAPK, AKT and STAT3.

IC 50

VEGFR2: 4.68 μM (IC50)

3,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE synthesis

117-39-5
552-54-5
Synthesis of 3,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE from Quercetin

3,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE Preparation Products And Raw materials

Raw materials

4H-1-Benzopyran-4-one, 3-((6-o-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-5-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-7-methoxy- 2-(2,2-Diphenyl-1,3-benzodioxol-5-yl)-5,7-dihydroxy-3-(phenylmethoxy)-4H-1-benzopyran-4-one 2-(2,2-diphenylbenzo[d][1,3]dioxol-5-yl)-3,5,7-trihydroxy-4H-chroMen-4-one Rhamnetin Quercetin

Preparation Products

3,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE Suppliers

Global( 63)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Zheyan Biotech Co., Ltd. 		18017610038 zheyansh@163.com CHINA 3619 58
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29860 58
Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39894 58
Shaanxi Dideu Medichem Co. Ltd 		+86-29-87569266 15319487004 1015@dideu.com China 3978 58
Hubei Ipure Biology Co., Ltd 		+8613367258412 ada@ipurechemical.com China 10244 58
HONG KONG IPURE BIOLOGY CO.,LIMITED 		86 18062405514 18062405514 ada@ipurechemical.com CHINA 3461 58
Labnetwork lnc. 		+86-27-50766799 +8618062016861 contact@labnetwork.com China 19987 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38630 58
Shanghai Acmec Biochemical Technology Co., Ltd. 		+86-18621343501; +undefined18621343501 product@acmec-e.com China 33338 58
SHANGHAI KEAN TECHNOLOGY CO., LTD. 		+8613817748580 cooperation@kean-chem.com China 40066 58
Supplier Advantage
Shanghai Zheyan Biotech Co., Ltd. 		58
career henan chemical co 		58
Chongqing Chemdad Co., Ltd 		58
Shaanxi Dideu Medichem Co. Ltd 		58
Hubei Ipure Biology Co., Ltd 		58
HONG KONG IPURE BIOLOGY CO.,LIMITED 		58
Labnetwork lnc. 		58
TargetMol Chemicals Inc. 		58
Shanghai Acmec Biochemical Technology Co., Ltd. 		58
SHANGHAI KEAN TECHNOLOGY CO., LTD. 		58

View Lastest Price from 3,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE pictures 2019-07-06 3,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE
552-54-5
 US $1.00 / KG 1g 99% 100KG Career Henan Chemical Co
rhamnacene 7,3'-DiMethylquercetin NSC 678106 Quercetin 7,3'-DiMethyl Ether RhaMnacine RHAMNAZIN(SH) 3,7-DIMETHYLQUERCETIN 3,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE QUERCETIN-3,7-DIMETHYL ETHER 3,5-Dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-7-methoxy-4H-1-benzopyran-4-one 3',7-Di-O-Methylquercetin 7,3'-Di-O-methylquercetin C.I.75700 4H-1-Benzopyran-4-one, 3,5-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-7-methoxy- 3,5-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-7-methoxychromen-4-one Quercetin 3’,7-Dimethyl ether 552-54-5 Aromatics Heterocycles Intermediates & Fine Chemicals Metabolites & Impurities Pharmaceuticals