β-Caryophyllene

β-Caryophyllene Properties

Melting point	<25℃
alpha	D -8 to -9° (chloroform)
Boiling point	129-130 °C/14 mmHg (lit.)
Density	0.901 g/mL at 25 °C (lit.)
vapor pressure	6Pa at 20℃
FEMA	2252 \| BETA-CARYOPHYLLENE
refractive index	n20/D 1.5(lit.)
Flash point	205 °F
storage temp.	-20°C
solubility	Chloroform (Sparingly), DMSO (Slightly), Methanol (Slightly)
form	Liquid
color	Colourless
Specific Gravity	0.90
Odor	at 100.00 %. sweet woody spice clove dry
Odor Type	spicy
optical activity	[α]23/D 7.5°, neat
Water Solubility	88μg/L at 20℃
Merck	14,1875
JECFA Number	1324
BRN	2044564
Stability	Light Sensitive
LogP	6.23 at 25℃
Substances Added to Food (formerly EAFUS)	BETA-CARYOPHYLLENE
FDA 21 CFR	172.515
CAS DataBase Reference	87-44-5(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	BHW853AU9H
EPA Substance Registry System	Bicyclo[7.2.0]undec-4-ene, 4,11,11-trimethyl-8-methylene-, (1R,4E,9S)- (87-44-5)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07,GHS08

Signal word

Danger

Hazard statements

H304-H317

Precautionary statements

P261-P272-P280-P301+P310-P302+P352-P331

Risk Statements

36/37/38

Safety Statements

26-36-24/25

RIDADR

UN1230 - class 3 - PG 2 - Methanol, solution

WGK Germany

1

RTECS

DT8400000

HS Code

29021990

NFPA 704

	1
0		0

β-Caryophyllene price More Price(38)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	W225299	β-Caryophyllene natural, ≥80%, FG	87-44-5	SAMPLE-K	$56	2024-03-01	Buy
Sigma-Aldrich	W225299	β-Caryophyllene natural, ≥80%, FG	87-44-5	1KG	$117	2024-03-01	Buy
Sigma-Aldrich	W225299	β-Caryophyllene natural, ≥80%, FG	87-44-5	9KG	$526	2024-03-01	Buy
Sigma-Aldrich	W225299	β-Caryophyllene natural, ≥80%, FG	87-44-5	20KG	$656	2024-03-01	Buy
Sigma-Aldrich	W225207	β-Caryophyllene ≥80%, FCC, FG	87-44-5	1kg	$79.8	2024-03-01	Buy

Product number	Packaging	Price	Buy
W225299	SAMPLE-K	$56	Buy
W225299	1KG	$117	Buy
W225299	9KG	$526	Buy
W225299	20KG	$656	Buy
W225207	1kg	$79.8	Buy

β-Caryophyllene Chemical Properties,Uses,Production

Description

β-Caryophyllene is a sesquiterpene that has been found in plants, including C. sativa, C. indica, and hemp, and has diverse biological activities, including lipid metabolic, antioxidant, anti-neuroinflammatory, anti-proliferative, and antinociceptive properties.

Chemical Properties

β-Caryophyllene has a woody-spicy, dry, clove-like aroma.

Occurrence

Three isomers (α-, β-, and γ-caryophyllene) are found in nature. The β-isomer is the most frequently encountered and most abundant. This sesquiterpene hydrocarbon occurs naturally in approximately 60 essential oils, mainly in that of cloves, from which it was originally isolated. The chemical structure has been thoroughly studied; other studies have been conducted on the isolation and the dipolar moment, as well as on its oxide. Reported found in lime peel oil, lemon, grapefruit, guava fruit, raspberry, black currant, carrot, celery seed, cinnamon bark, anise, nutmeg, cumin seed, ginger, pepper, peppermint oil, mace, laurel and caraway herb.

Uses

β-Caryophyllene is notable for having a cyclobutane ring, a rarity in nature. β-Caryophyllene is one of the chemical compounds that contributes to the spiciness of black pepper. β-Caryophyllene was shown to selectively bind to the cannabinoid receptor type-2 (CB2) and to exert significant cannabimimetic antiinflammatory effects in mice.

Preparation

Isolated from oil of clove stems and separated from eugenol by treating the oil with 7% sodium carbonate solution, extracting with ether, repeating the carbonate treatment on the concentrated extracts, and finally steam distilling.

Definition

ChEBI: A beta-caryophyllene in which the stereocentre adjacent to the exocyclic double bond has S configuration while the remaining stereocentre has R configuration. It is the most commonly occurring form of <greek beta-caryophyllene, occurring in many essential oils, particularly oil of cloves.

Aroma threshold values

Detection at 64 to 90 ppb

Taste threshold values

Taste characteristics at 50 ppm: spicy, pepper-like, woody, camphoraceous with a citrus background.

Synthesis Reference(s)

Journal of the American Chemical Society, 86, p. 485, 1964 DOI: 10.1021/ja01057a040

Air & Water Reactions

Insoluble in water.

Reactivity Profile

The unsaturated aliphatic hydrocarbons, such as BETA-CARYOPHYLLENE, are generally much more reactive than the alkanes. Strong oxidizers may react vigorously with them. Reducing agents can react exothermically to release gaseous hydrogen. In the presence of various catalysts (such as acids) or initiators, compounds in this class can undergo very exothermic addition polymerization reactions.

Health effects

β-caryophyllene has shown anti-inflammatory activity via decreasing TLR-4, IL-1?, and TNF-α levels. It attenuated oxidative stress by restoring antioxidant enzymes and repressing lipid peroxidation as well as GSH depletion.

Fire Hazard

BETA-CARYOPHYLLENE is combustible.

Safety Profile

A skin irritant. Combustible liquid. When heated to decomposition it emits acrid smoke and irritating fumes.

Carcinogenicity

Caryophyllene showed significant activity as an inducer of the detoxifying enzyme glutathione S-transferase in the mouse liver and small intestine. The ability of natural anticarcinogens to induce detoxifying enzymes has been found to correlate with their activity in the inhibition of chemical carcinogenesis (253a).

β-Caryophyllene Preparation Products And Raw materials

Raw materials

CLOVE STEM OIL Cassia Aurantium P.E Catechins 8% HPLC EUGENIA CARYOPHYLLUS (CLOVE) LEAF OIL

Preparation Products

Caryophyllenolexcloveleafoil (-)-ALPHA-NEOCLOVENE ALPHA-CARYOPHYLLENE

β-Caryophyllene Suppliers

Global( 400)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Weibang Biotechnology Co., Ltd	+8615531157085	abby@weibangbio.com	China	8811	58
Hebei Mojin Biotechnology Co., Ltd	+86 13288715578 +8613288715578	sales@hbmojin.com	China	12840	58
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5857	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-13131129325	sales1@chuanghaibio.com	China	5893	58
Hebei Weibang Biotechnology Co., Ltd	+8617732866630	bess@weibangbio.com	China	18153	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971 +86-17331933971	deasea125996@gmail.com	China	2472	58
Hebei Kingfiner Technology Development Co.Ltd	+86-15532196582 +86-15373005021	lisa@kingfinertech.com	China	3010	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20287	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	+8613343047651	admin@zlchemi.com	China	3002	58
Hebei Mojin Biotechnology Co.,Ltd	+86-15028179902	angelia@hbmojin.com	China	1177	58

Supplier	Advantage
Hebei Weibang Biotechnology Co., Ltd	58
Hebei Mojin Biotechnology Co., Ltd	58
Hebei Yanxi Chemical Co., Ltd.	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Hebei Weibang Biotechnology Co., Ltd	58
Henan Bao Enluo International TradeCo.，LTD	58
Hebei Kingfiner Technology Development Co.Ltd	58
Henan Fengda Chemical Co., Ltd	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	58
Hebei Mojin Biotechnology Co.,Ltd	58

View Lastest Price from β-Caryophyllene manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-22	Beta-Caryophyllene 87-44-5	US $120.00 / kg	1kg	99%	20ton	Hebei Zhuanglai Chemical Trading Co.,Ltd
2024-11-19	β-Caryophyllene 87-44-5	US $41.00 / mg		99.11%	10g	TargetMol Chemicals Inc.
2024-10-30	BETA-CARYOPHYLLENE 87-44-5	US $0.00-0.00 / KG	1KG	99%	500000kg	Hebei Weibang Biotechnology Co., Ltd

Beta-Caryophyllene
87-44-5
US $120.00 / kg
99%
Hebei Zhuanglai Chemical Trading Co.,Ltd

β-Caryophyllene
87-44-5
US $41.00 / mg
99.11%
TargetMol Chemicals Inc.

BETA-CARYOPHYLLENE
87-44-5
US $0.00-0.00 / KG
99%
Hebei Weibang Biotechnology Co., Ltd

β-Caryophyllene Spectrum

BETA-CARYOPHYLLENE(87-44-5)FT-IR BETA-CARYOPHYLLENE(87-44-5)IR

87-44-5(β-Caryophyllene)Related Search:

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CARYOPHYLLENE, (-)-trans-(SG) HUMULENE, alpha-(SG) 8-METHYLENE-4,11,11-TRIMETHYLBICYCLO-UNDEC-4-ENE CAROPHYLENE BETA-CARYPOPHYLLENE CARYOPHYLLEN BETA NATUERLICH NATURAL β-CARYOPHYLLENE B-CARYOPHYLLENE, NATURAL 8-METHYLENE-4,11,11-TRIMETHYLBICYCLO[7.2.0]UNDEC-4-ENE FCC (-)-TRANS-CARYOPHYLLENE WITH GC BETA-CARYOPHYLLENE 80+% FCC (1R,9S)-8-METHYLEN-4,11,11-TRIMETHYL-BICYCLO[7.2.0]UNDEC-4-ENE 8-METHYLENE-4,11,11-TRIMETHYLBICYCLO[7.2.0]UNDEC-4-ENE BETA-CARYOPHYLLEN BETA-CARYOPHYLLENE CARYOPHYLLENE, (-)-TRANS- FEMA 2252 TRANS-(1R,9S)-8-METHYLENE-4,11,11-TRIMETHYLBICYCLO[7.2.0]UNDEC-4-ENE (-) TRANS CARYOPHYLLEN (-)-TRANS-CARYOPHYLLENE (-)-E-caryophyllene (E)-beta-Caryophylene [1R-(1R*,4E,9S*)]-4,11,11-trimethyl-8-methylene-bicyclo[7.2.0]-4-undecene [1R-(1R*,4E,9S*)]-8-methylene-4,11,11-trimethylbicyclo[7.2.0]-4-undecane 4,11,11-trimethyl-8-methylene-,(1r-(1r*,4e,9s*))-bicyclo(7.2.0)undec-4-en 4,11,11-trimethyl-8-methylene-,[1R-(1R*,4E,9S*)]-Bicyclo[7.2.0]undec-4-ene 8-methylene-4,11,11-trimethyl-,(e)-(1r,9s)-(-)-bicyclo(7.2.0)undec-4-en beta-(E)-Caryophyllene beta-cariofillene beta-trans-caryophyllene Bicyclo(7.2.0)undec-4-ene, 8-methylene-4,11,11-trimethyl-, (E)-(1R,9S)-(-)- Bicyclo[7.2.0]undec-4-ene, 4,11,11-trimethyl-8-methylene-, [1R-(1R*,4E,9S*)]- Caryophyllene (E) CARYOPHYLLENE ,alpha + beta MIXT. E-beta-caryophyllene t-.beta.-caryophyllene (1R,4E,9S)-4,11,11-Trimethyl-8-methylenebicyclo[7.2.0]undec-4-ene (E,1R,9S)-4,11,11-Trimethyl-8-methylenebicyclo[7.2.0]undec-4-ene 1R-(1R*,4E,9S*)-4,11,11-Trimethyl-8-methylenebicyclo[7.2.0]undec-4-ene trans-(1R,9S)-8-Methylene-4,11,11-trimethylbicyclo[7.2.0] B-Caryophyllene Fcc ()-trans-Caryophyllene,β-Caryophyllene, trans-(1R,9S)-8-Methylene-4,11,11-trimethylbicyclo[7.2.0]undec-4-ene β-Caryophyllene,()-trans-Caryophyllene, trans-(1R,9S)-8-Methylene-4,11,11-trimethylbicyclo[7.2.0]undec-4-ene β-Caryophyllene, froM CinnaMoMuM caMphora (-)-trans-Caryophyllene >=98.5% (suM of enantioMers, GC) β-Caryophyllene Beta-87-44-5 factory Direct Salebest in Quality NATURAL B-CARYOPHYLLENE TIANFU CHEM-- BETA-CARYOPHYLLENE (1R,9S,E)-4,11,11-Trimethyl-8-methylenebicyclo[7.2.0]undec-4-ene beta-Caryophyllene solution Eugenol EP Impurity A β-Caryophyllene, 90%, from Cinnamomum camphora (L.) J. Presl β-Caryophyllene ( (-)-trans-Caryophyllene) (-)-trans-Caryophyllene Solution (-)-trans-Caryophyllene@100 μg/mL in Methanol (-)-β-caryophyllene BETA-CARYOPHYLLENE USP/EP/BP