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GW9662

CAS No.
22978-25-2
Chemical Name:
GW9662
Synonyms
2-CHLORO-5-NITRO-N-PHENYLBENZAMIDE;CS-762;GW9662;GW9662, >=98%;GW9662; GW 9662;GW9662 USP/EP/BP;TIMTEC-BB SBB006523;2-CHLORO-5-NITROBENZANILIDE;2-Chloro-5-nitrobenzanilide 97%;GW9662;GW 9662;TIMTEC-BB SBB006523
CBNumber:
CB3431922
Molecular Formula:
C13H9ClN2O3
Molecular Weight:
276.68
MDL Number:
MFCD01215270
MOL File:
22978-25-2.mol
MSDS File:
SDS
Last updated:2024-11-19 20:33:22

GW9662 Properties

Melting point 158-159 °C (lit.)
Boiling point 360.9±32.0 °C(Predicted)
Density 1.440±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: 26 mg/mL, soluble
form solid
pka 11.77±0.70(Predicted)
color white
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChIKey DNTSIBUQMRRYIU-UHFFFAOYSA-N
CAS DataBase Reference 22978-25-2(CAS DataBase Reference)
FDA UNII UM18UZV2YD

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H317-H319-H315-H335
Precautionary statements  P261-P302+P352-P321-P405-P501-P280-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36-43
Safety Statements  26-36/37-24/25-22
WGK Germany  3
HS Code  29242990
NFPA 704
0
2 0

GW9662 price More Price(33)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich M6191 GW 9662 >98% (HPLC) 22978-25-2 5mg $90.5 2024-03-01 Buy
Sigma-Aldrich 642355 2-Chloro-5-nitrobenzanilide 97% 22978-25-2 25g $282 2023-01-07 Buy
Alfa Aesar J65634 GW 9662 22978-25-2 10mg $108.65 2024-03-01 Buy
Alfa Aesar J65634 GW 9662 22978-25-2 50mg $406 2021-12-16 Buy
Cayman Chemical 70785 GW 9662 ≥98% 22978-25-2 1mg $12 2024-03-01 Buy
Product number Packaging Price Buy
M6191 5mg $90.5 Buy
642355 25g $282 Buy
J65634 10mg $108.65 Buy
J65634 50mg $406 Buy
70785 1mg $12 Buy

GW9662 Chemical Properties,Uses,Production

Description

GW-9662 (22978-25-2) is a selective PPARγ antagonist (IC50 = 3.3, 32 and 2000 nM for PPARγ, PPARα and PPARδ respectively).1 Blocks the inhibition of osteoclast formation induced by IL-4 (1-2 μM).2 Displays anticancer activity inhibits growth of human mammary tumor cell lines.3 GW-9662 is a useful tool for dissecting the involvement of PPARγ in cellular physiology.4,5

Chemical Properties

Off-White Solid

Uses

A cell-permeable, selective and irreversible PPAR antagonist (IC50 = 3.3 nM, 32 nM, and 2 for PPAR, PPARa, and PPARd, respectively). Reported to covalently modify a cysteine residue in the binding site of PPAR. At a concentration of 10 , also

Uses

GW9662 has been used as a peroxisome proliferator activated receptor γ (PPARγ) antagonist in human pluripotent stem cells, in phenylephrine stimulated cardiomyocytes and to inhibit the protective effect of telmisartan pheochromocytoma, PC12 cells.

Uses

An irreversible PPAR antagonist

Definition

ChEBI: GW 9662 is a member of benzamides.

Biological Activity

Selective PPAR γ antagonist (IC 50 values are 3.3, 32 and 2000 nM for PPAR γ , PPAR α and PPAR δ respectively). Blocks the inhibition of osteoclast formation induced by IL-4 in the low micromolar range (1-2 μ M), therefore is more potent than BADGE (2,2-Bis[4-(2,3-epoxypropoxy)phenyl]propane ). Anticancer, inhibits growth of human mammary tumor cell lines.

Biochem/physiol Actions

GW9662 (2-chloro-5-nitrobenzanilide) binds to the ligand binding site of the peroxisome proliferator activated receptor γ (PPARγ) and results in the inhibition of adipocyte differentiation. It favors cell growth suppression in breast cancer cell lines even in the presence of PPARγ agonist rosiglitazone. It stimulates M2c macrophages differentiation and triggers growth arrest-specific 6 (Gas6) expression. GW9662 co treatment with other PPARγ ligands elicits antiproliferative effects on the glioblastoma stem cells and could be a potent therapeutic agent.

storage

Store at RT

References

1) Leesnitzer et al. (2002), Functional consequences of cysteine modification in the ligand binding sites of peroxisome proliferator activated receptors by GW9662; Biochemistry, 41 6640 2) Bendixen et al. (2001), IL-4 inhibits osteoclast formation through a direct action on osteoclast precursors via peroxisome proliferator-activated receptor gamma 1; Proc. Natl. Acad. Sci. USA, 98 2443 3) Seargent et al. (2004), GW9662, a potent antagonist of PPARgamma inhibits growth of breast cancer tumour cells and promotes the anticancer effects of the PPARgamma agonist rosiglitazone, independently of PPARgamma activation; Br. J. Pharmacol., 143 933 4) Cheng et al. (2014), β-Caryophyllene Ameliorates the Alzheimer-Like Phenotype in APP/PS1 Mice through CB2 Receptor Activation and the PPARγ Pathway; Pharmacology, 94 1 5) Liu et al. (2014), Curcumin protects neurons against oxygen-glucose deprivation/reoxygenation-induced injury through activation of peroxisome proliferator-activated-γ function; J. Neuro. Sci. Res., 92 1549

GW9662 Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 240)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32957 60
Biochempartner
0086-13720134139 candy@biochempartner.com CHINA 965 58
Hubei Jusheng Technology Co.,Ltd.
18871490254 linda@hubeijusheng.com CHINA 28172 58
career henan chemical co
+86-0371-86658258 +8613203830695 factory@coreychem.com China 29811 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
Hubei Ipure Biology Co., Ltd
+8613367258412 ada@ipurechemical.com China 10319 58
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418671 +8618949823763 sales@tnjchem.com China 34563 58
HONG KONG IPURE BIOLOGY CO.,LIMITED
86 18062405514 18062405514 ada@ipurechemical.com CHINA 3461 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250 1026@dideu.com China 22784 58
Dayang Chem (Hangzhou) Co.,Ltd.
571-88938639 +8617705817739 info@dycnchem.com China 52849 58

View Lastest Price from GW9662 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
GW9662 pictures 2024-11-19 GW9662
22978-25-2
US $47.00-92.00 / mg 99.94% 10g TargetMol Chemicals Inc.
GW9662 pictures 2020-02-01 GW9662
22978-25-2
US $3.00 / KG 1KG 98% 100KG Career Henan Chemical Co
  • GW9662 pictures
  • GW9662
    22978-25-2
  • US $47.00-92.00 / mg
  • 99.94%
  • TargetMol Chemicals Inc.
  • GW9662 pictures
  • GW9662
    22978-25-2
  • US $3.00 / KG
  • 98%
  • Career Henan Chemical Co

GW9662 Spectrum

GW9662, >=98% 2-CHLORO-5-NITROBENZANILIDE GW9662 TIMTEC-BB SBB006523 2-Chloro-5-nitro-N-4-phenylbenzamide BenzaMide,2-chloro-5-nitro-N-phenyl- N-[(2-chloro-5-nitrophenyl)-phenylmethylidene]hydroxylamine 2-Chloro-5-nitrobenzanilide 97% GW9662;GW 9662;TIMTEC-BB SBB006523 GW9662 - CAS 22978-25-2 - Calbiochem CS-762 GW9662; GW 9662 GW9662 USP/EP/BP 2-CHLORO-5-NITRO-N-PHENYLBENZAMIDE GW9662,Peroxisome proliferator-activated receptors,PPAR,GW-9662,Inhibitor,inhibit 22978-25-2 C13H19N2O3Cl ClC6H3NO2CONHC6H5 Gene Regulation and Expression Organic Building Blocks PPAR and RXR Regulators Building Blocks Amides BioChemical Cell Signaling and Neuroscience Cell Biology Carbonyl Compounds Inhibitor Intracellular receptor Inhibitors Amides Carbonyl Compounds Organic Building Blocks