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R-(-)-Apomorphine

R-(-)-Apomorphine structure

CAS No.: 41372-20-7

Chemical Name:: R-(-)-Apomorphine

Synonyms: Apokyn;R-(-)-APOMORPHINE HYDROCHLORIDE HEMIHYDRATE;r-(-)-apomorphine;Apokyn HeMihydrate;Ixense HeMihydrate;ApoMorphin HeMihydrate;ApoMorphine HeMihydrate;Apomorphine HCl hydrate;APOMORPHINEHCLHEMIHYDRATE;Apomophine hydrochloride

CBNumber:: CB3447114

Molecular Formula:: C17H20ClNO3

Molecular Weight:: 321.8

MDL Number:: MFCD27966809

MOL File:: 41372-20-7.mol

Last updated:2024-07-02 08:55:06

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R-(-)-Apomorphine Properties

Melting point	285-287 °C(lit.)
alpha	-48 º (c=1, H2O)
storage temp.	Refrigerator
solubility	H₂O: ~10 mg/mL, clear, yellow-green
form	Solid
color	white to gray
PH	pH(10g/l, 25℃) : 4.0～5.0
Merck	13,751
Stability	Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 week.
CAS DataBase Reference	41372-20-7(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	F39049Y068

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS06
Signal word	Danger
Hazard statements	H301
Precautionary statements	P301+P330+P331+P310
Hazard Codes	Xn
Risk Statements	22
Safety Statements	36
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
HS Code	2933997000

R-(-)-Apomorphine price More Price(24)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	PHR2621	Apomorphine hydrochloride PharmaceuticalSecondaryStandard;CertifiedReferenceMaterial	41372-20-7	500MG	$226	2024-03-01	Buy
Sigma-Aldrich	A4393	R-(?)-Apomorphine hydrochloride hemihydrate calcined, ≥98.5%	41372-20-7	1g	$290	2024-03-01	Buy
Sigma-Aldrich	1041008	Apomorphine hydrochloride United States Pharmacopeia (USP) Reference Standard	41372-20-7	250mg	$457	2024-03-01	Buy
Sigma-Aldrich	A4393	R-(?)-Apomorphine hydrochloride hemihydrate calcined, ≥98.5%	41372-20-7	100mg	$57.7	2024-03-01	Buy
Sigma-Aldrich	A4393	R-(?)-Apomorphine hydrochloride hemihydrate calcined, ≥98.5%	41372-20-7	250mg	$95.3	2024-03-01	Buy

Product number	Packaging	Price	Buy
PHR2621	500MG	$226	Buy
A4393	1g	$290	Buy
1041008	250mg	$457	Buy
A4393	100mg	$57.7	Buy
A4393	250mg	$95.3	Buy

R-(-)-Apomorphine Chemical Properties,Uses,Production

Description

Apomorphine (41372-20-7) is an archetypal dopamine pan-receptor agonist. Displays anti-Parkinsons activity in vivo.1 Protects against MPTP-induced neurotoxicity in a mouse mode1,2 In clinical use for Parkinson’s disease.4,5

Chemical Properties

Off-White Solid

Uses

R-(?)-Apomorphine hydrochloride hemihydrate is a nonselective dopamine agonist with anti-Parkinsonian and neuroprotective effects in vivo.

Uses

Dopamine (D1 and D2) receptor agonist. Emetic. Antiparkinsonian.

Uses

emetic, antiparkinsonian, erextile dysfunction therapy

brand name

Apokyn (Vernalis).

Purification Methods

Crystallise the salt from H2O (hemihydrate) and from EtOH. Crystals turn green on exposure to light. (see previous entry). NARCOTIC.

References

1) Merck Index 14:746 2) Millan et al. (2002), Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes; J. Pharmacol. Exp. Therap., 303 791 3) Grunblatt et al. (1999), Apomorphine protects against MPTP-induced neurotoxicity in mice.; Mov. Discord, 14 612 4) Auffret et al. (2017), Apomorphine pump in advanced Parkinson’s disease: Effects on motor and nonmotor symptoms with brain metabolism correlations; J. Neurol. Sci, 372 279 5) Jenner and Katzenschlager (2016), Apomorphine – pharmacological properties and clinical trials in Parkinson’s disease; Parkinsonism. Related. Disord., 33 Suppl. 1:S13

R-(-)-Apomorphine Preparation Products And Raw materials

Raw materials

MORPHINE Sodium sulfite CHLOROETHANE Activated carbon,decolor

Preparation Products

R-(-)-Apomorphine Suppliers

Global( 89)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971 +86-17331933971	deasea125996@gmail.com	China	2472	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21634	55
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49374	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32165	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	7724	58
Hebei Dangtong Import and export Co LTD	+86-13910575315 +86-13910575315	admin@hbdangtong.com	China	1000	58
GIHI CHEMICALS CO.,LIMITED	+8618058761490	info@gihichemicals.com	China	49978	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57505	58
Mainchem Co., Ltd.	+86-0592-6210733	sale@mainchem.com	China	32343	55
LGM Pharma	1-(800)-881-8210	inquiries@lgmpharma.com	United States	2123	70

Supplier	Advantage
Henan Bao Enluo International TradeCo.，LTD	58
Henan Tianfu Chemical Co.,Ltd.	55
CONIER CHEM AND PHARMA LIMITED	58
TargetMol Chemicals Inc.	58
Shaanxi Dideu Medichem Co. Ltd	58
Hebei Dangtong Import and export Co LTD	58
GIHI CHEMICALS CO.,LIMITED	58
Aladdin Scientific	58
Mainchem Co., Ltd.	55
LGM Pharma	70

View Lastest Price from R-(-)-Apomorphine manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-10-24	R-(-)-Apomorphine 41372-20-7	US $11500.00-11460.00 / kilograms	10kilograms	99%	100tons	Hebei Dangtong Import and export Co LTD
	2023-06-30	R-(-)-Apomorphine 41372-20-7	US $10.00 / kg	1kg	99.99%	50000tons	Henan Bao Enluo International TradeCo.，LTD

R-(-)-Apomorphine
41372-20-7
US $11500.00-11460.00 / kilograms
99%
Hebei Dangtong Import and export Co LTD

R-(-)-Apomorphine
41372-20-7
US $10.00 / kg
99.99%
Henan Bao Enluo International TradeCo.，LTD

R-(-)-Apomorphine Spectrum

R-(-)-Apomorphine(41372-20-7)¹HNMR R-(-)-Apomorphine(41372-20-7)Raman R-(-)-Apomorphine(41372-20-7)IR

41372-20-7(R-(-)-Apomorphine)Related Search:

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Parathion-methyl MORPHINE apomorphine

1of4

(r)-5,6,6a,7-tetrahydro-6-methyl-4h-dibenzo[de,g]quinoline-10,11-diol Apomorphine hydrochloride R-(-)- (6Ar)-5,6,6A,7-tetrahydro-6-methyl-4H-dibenzo(de,G)chinolin-10,11-diol hydrochlorid 6a-beta-aporphine-10,11-diol APOMORPHINE HYDROCHLORIDE, HEMIHYDRATE 4H-Dibenzode,gquinoline-10,11-diol, 5,6,6a,7-tetrahydro-6-methyl-, hydrochloride, hydrate (2:1), (6aR)- APOMORPHINEHCLHEMIHYDRATE APOMORPHINEHYDROCHLORIDE,HEMIHYDRATE,USP Apomophine hydrochloride R-(-)-Apomorphine hemihydrate hydrochloride 4H-Dibenzo(de,G)quinoline-10,11-diol, 5,6,6A,7-tetrahydro-6-methyl-, hydrochloride, hemihydrate, (R)- Apomorphin hydrochlorid wasser (2/1) Apomorphine Hydrochloride (250 mg) (-)-10,11-Dihydroxy-aporphine Hydrochloride HeMihydrate (6aR)-5,6,6a,7-Tetrahydro-6-Methyl-4H-dibenzo[de,g]quinoline-10,11-diol Hydrochloride HeMihydrate 6aβ-Aporphine-10,11-diol Hydrochloride HeMihydrate Apokyn HeMihydrate ApoMorphin HeMihydrate ApoMorphine HeMihydrate Ixense HeMihydrate l-ApoMorphine HeMihydrate r-(-)-apomorphine:6a-beta-aporphine-10,11-diol: (r)-5,6,6a,7-tetrahydro-6-methyl-4h-dibenzo(de,g)QUINOLINE-10,11-diol R-(-)-Apomorphine HCl Hemihydrate r-(-)-apomorphine Apomorphine hydrochloride hemihydrate CRS Apomorphine HCl hydrate R-(-)-Apomorphine USP/EP/BP Apomorphine Hydrochloride (1041008) Apokyn R-(-)-APOMORPHINE HYDROCHLORIDE HEMIHYDRATE a . N-(2-a mi noe th yl)-2-(b e nzylph e nyla mi no)a c e ta mi d e . Apomorphine HCl Reference Standard Apomorphine hydrochloride hemihydrate in methanol 41372-20-7 C17H18ClNO212H2O C17H17NO2HCl12H2O C17H17NO222HClH2O C17H20ClNO3 C17H18ClNO2H2O 31279 Nonselective dopamine agonist; causes nausea and emesis. Chiral Building Blocks Asymmetric Synthesis Others Heterocyclic Building Blocks Inhibitors APOKYN Chiral Reagents Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Agonists Dopaminergics Neurotransmitters Erectile Dysfunction Dopamine receptor