CAY10722
- CAS No.
- 388086-13-3
- Chemical Name:
- CAY10722
- Synonyms
- CAY10722;CAY10722,CAY-10722;N-[2-(2,4-Dichlorophenyl)-5-benzoxazolyl]benzeneacetamide;Benzeneacetamide, N-[2-(2,4-dichlorophenyl)-5-benzoxazolyl]-
- CBNumber:
- CB34666313
- Molecular Formula:
- C21H14Cl2N2O2
- Molecular Weight:
- 397.25
- MDL Number:
- MFCD01839641
- MOL File:
- 388086-13-3.mol
CAY10722 price More Price(5)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 22404 | CAY10722 ≥98% | 388086-13-3 | 1mg | $32 | 2024-03-01 | Buy |
Cayman Chemical | 22404 | CAY10722 ≥98% | 388086-13-3 | 5mg | $139 | 2024-03-01 | Buy |
Cayman Chemical | 22404 | CAY10722 ≥98% | 388086-13-3 | 10mg | $243 | 2024-03-01 | Buy |
Cayman Chemical | 22404 | CAY10722 ≥98% | 388086-13-3 | 25mg | $533 | 2024-03-01 | Buy |
AK Scientific | 7248CE | N-[2-(2,4-Dichlorophenyl)-1,3-benzoxazol-5-yl]-2-phenylacetamide | 388086-13-3 | 10mg | $370 | 2021-12-16 | Buy |
CAY10722 Chemical Properties,Uses,Production
Description
CAY10722 is an inhibitor of sirtuin 3 (SIRT3), a class III HDAC (71% inhibition at 200 μM).1 SIRT3 is involved in modulating metabolic homeostasis as a NAD+-dependent protein deacetylase in the mitochondria. SIRT3 functions as either an oncogene or tumor suppressor, depending on cancer cell type.2,3 High SIRT3 expression in patient-derived esophageal cancer tissues is associated with shorter survival and, in mice, downregulation leads to a lower tumor load.4 In contrast, low SIRT3 expression in patient-derived breast cancer cells is correlated with shorter survival.5
References
1. Salo, H.S., Latinen, T., Poso, A., et al. Identification of novel SIRT3 inhibitor scaffolds by virtual screening Bioorg. Med. Chem. Lett. 23(10),2990-2995(2013).
2. Chen, Y., Fu, L., Wen, X., et al. Sirtuin-
3. Xiong, Y., Wang, M., Zhao, J., et al. Sirtuin 3: A Janus face in cancer (Review) Int. J. Oncol. 49(6),2227-2235(2016).
4. Zhao, Y., Yang, H., Wang, X., et al. Sirtuin-
5. Desouki, M.M., Doubinskaia, I., Gius, D., et al. Decreased mitochondrial SIRT3 expression is potential molecular biomarker associated with poor outcome in breast cancer Hum. Pathol. 45(5),1071–1077(2014).
CAY10722 Preparation Products And Raw materials
Raw materials
Preparation Products
CAY10722 Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
BOC Sciences | 16314854226 | info@bocsci.com | United States | 9926 | 65 |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9704 | 58 |
Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 23980 | 58 |
Suzhou Zhixin Biotechnology Co., Ltd. | 0512-65118909 15162312715 | sales@szzxbio.com | China | 2997 | 58 |
Nanjing Tengyi Biotechnology Co., Ltd | 025-58851786 17714337195 | sales@tybiochem.com | China | 5584 | 58 |