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CAY10722

CAY10722 Structure
CAY10722 structure
CAS No.
388086-13-3
Chemical Name:
CAY10722
Synonyms
CAY10722;CAY10722,CAY-10722;N-[2-(2,4-Dichlorophenyl)-5-benzoxazolyl]benzeneacetamide;Benzeneacetamide, N-[2-(2,4-dichlorophenyl)-5-benzoxazolyl]-
CBNumber:
CB34666313
Molecular Formula:
C21H14Cl2N2O2
Molecular Weight:
397.25
MDL Number:
MFCD01839641
MOL File:
388086-13-3.mol
Last updated:2023-05-21 10:59:17
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CAY10722 Properties

Boiling point 598.7±50.0 °C(Predicted)
Density 1.406±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml; Ethanol: Slightly soluble
form A crystalline solid
pka 13.04±0.43(Predicted)

CAY10722 price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 22404 CAY10722 ≥98% 388086-13-3 1mg $32 2024-03-01 Buy
Cayman Chemical 22404 CAY10722 ≥98% 388086-13-3 5mg $139 2024-03-01 Buy
Cayman Chemical 22404 CAY10722 ≥98% 388086-13-3 10mg $243 2024-03-01 Buy
Cayman Chemical 22404 CAY10722 ≥98% 388086-13-3 25mg $533 2024-03-01 Buy
AK Scientific 7248CE N-[2-(2,4-Dichlorophenyl)-1,3-benzoxazol-5-yl]-2-phenylacetamide 388086-13-3 10mg $370 2021-12-16 Buy
Product number Packaging Price Buy
22404 1mg $32 Buy
22404 5mg $139 Buy
22404 10mg $243 Buy
22404 25mg $533 Buy
7248CE 10mg $370 Buy

CAY10722 Chemical Properties,Uses,Production

Description

CAY10722 is an inhibitor of sirtuin 3 (SIRT3), a class III HDAC (71% inhibition at 200 μM).1 SIRT3 is involved in modulating metabolic homeostasis as a NAD+-dependent protein deacetylase in the mitochondria. SIRT3 functions as either an oncogene or tumor suppressor, depending on cancer cell type.2,3 High SIRT3 expression in patient-derived esophageal cancer tissues is associated with shorter survival and, in mice, downregulation leads to a lower tumor load.4 In contrast, low SIRT3 expression in patient-derived breast cancer cells is correlated with shorter survival.5

References

1. Salo, H.S., Latinen, T., Poso, A., et al. Identification of novel SIRT3 inhibitor scaffolds by virtual screening Bioorg. Med. Chem. Lett. 23(10),2990-2995(2013).
2. Chen, Y., Fu, L., Wen, X., et al. Sirtuin-3 (SIRT3), a therapeutic target with oncogenic and tumor-suppressive function in cancer Cell Death Dis. 5(e1047),1-7(2014).
3. Xiong, Y., Wang, M., Zhao, J., et al. Sirtuin 3: A Janus face in cancer (Review) Int. J. Oncol. 49(6),2227-2235(2016).
4. Zhao, Y., Yang, H., Wang, X., et al. Sirtuin-3 (SIRT3) expression is associated with overall survival in esophageal cancer Ann. Diagn. Pathol. 17(6),483-485(2013).
5. Desouki, M.M., Doubinskaia, I., Gius, D., et al. Decreased mitochondrial SIRT3 expression is potential molecular biomarker associated with poor outcome in breast cancer Hum. Pathol. 45(5),1071–1077(2014).

CAY10722 Preparation Products And Raw materials

Raw materials

Preparation Products

CAY10722 Suppliers

Global( 8)Suppliers
Supplier Tel Email Country ProdList Advantage
BOC Sciences 16314854226 info@bocsci.com United States 9926 65
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9708 58
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6870 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24017 58
Suzhou Zhixin Biotechnology Co., Ltd. 0512-65118909 15162312715 sales@szzxbio.com China 2992 58
Nanjing Tengyi Biotechnology Co., Ltd 025-58851786 17714337195 sales@tybiochem.com China 5595 58
Supplier Advantage
BOC Sciences 65
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai Hongye Biotechnology Co. Ltd 58
TargetMol Chemicals Inc. 58
Suzhou Zhixin Biotechnology Co., Ltd. 58
Nanjing Tengyi Biotechnology Co., Ltd 58
CAY10722 N-[2-(2,4-Dichlorophenyl)-5-benzoxazolyl]benzeneacetamide CAY10722,CAY-10722 Benzeneacetamide, N-[2-(2,4-dichlorophenyl)-5-benzoxazolyl]- 388086-13-3