EOS (d18:1/30:0/18:2)
- CAS No.
- 97040-38-5
- Chemical Name:
- EOS (d18:1/30:0/18:2)
- Synonyms
- EOS (d18:1/30:0/18:2);30-[[2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]amino]-30-oxotriacontylester,9,12-octadecadienoicacid;9,12-Octadecadienoic acid, 30-[[2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]amino]-30-oxotriacontyl ester
- CBNumber:
- CB34666409
- Molecular Formula:
- C66H125NO5
- Molecular Weight:
- 1012.7
- MDL Number:
- MOL File:
- 97040-38-5.mol
EOS (d18:1/30:0/18:2) price More Price(2)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 24394 | EOS (d18:1/30:0/18:2) ≥98% | 97040-38-5 | 1mg | $547 | 2024-03-01 | Buy |
| AK Scientific | 7036DP | [30-[[(E)-1,3-Dihydroxyoctadec-4-en-2-yl]amino]-30-oxotriacontyl](9Z,12Z)-octadeca-9,12-dienoate | 97040-38-5 | 1mg | $1016 | 2021-12-16 | Buy |
EOS (d18:1/30:0/18:2) Chemical Properties,Uses,Production
Description
EOS is a ceramide found in the outer layer of the epidermis in mammals.1 It is comprised of an ω-hydroxy very long-chain ceramide (C28-36) esterified to the essential fatty acid linoleic acid . The consecutive regio- and stereospecific oxygenation of the linoleate portion of EOS by 12(R)-lipoxygenase (12(R)-LO) and eLOX3 is essential for the maintenance of the epidermal barrier to prevent water loss. Following oxygenation, the oxidized linoleate is hydrolyzed, leaving the ω-hydroxy end of the very long-chain fatty acid to covalently bind the protein layer, forming the corneocyte lipid envelope and sealing the gap between the extracellular lipid lamellae and the cornified cell envelope of the corneocyte. EOS (d18:1/30:0/18:2) is a sphingolipid that has been found in intact and desquamated human stratum corneum as well as porcine epidermis.2,3
References
1. Zheng, Y., Yun, H., Boeglin, W.E., et al. Lipoxygenases mediate the effect of essential fatty acid in skin barrier formation: A proposed role in releasing omega-
2. Long, S.A., Wertz, P.W., Strauss, J.S., et al. Human stratum corneum polar lipids and desquamation Arch. Dermatol. Res. 277(4),284-287(1985).
3. Wertz, P.W., Abraham, W., Cho, E.S., et al. Linoleate-
EOS (d18:1/30:0/18:2) Preparation Products And Raw materials
Raw materials
Preparation Products
EOS (d18:1/30:0/18:2) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alfa Chemistry | Info@alfa-chemistry.com | United States | 24072 | 58 | |
| Yichang Zhongyitai Trading Co., Ltd. | 0717-6449896 13886658719 | root@zhongyitai.com | China | 1977 | 58 |
| Alfa Chemistry | 1-516-6625404 | support@alfa-chemistry.com | United States | 9171 | 60 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Shanghai Universal Biotech Co.,Ltd | 18768175414 | gaojun@univ-bio.com | China | 24998 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11975 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 19696 | 58 |