Ogerin
- CAS No.
- 1309198-71-7
- Chemical Name:
- Ogerin
- Synonyms
- Ogerin;Ogerin >=98% (HPLC);2-[4-Amino-6-[(phenylmethyl)amino]-1,3,5-triazin-2-yl]benzenemethanol;Benzenemethanol, 2-[4-amino-6-[(phenylmethyl)amino]-1,3,5-triazin-2-yl]-;G Protein-Coupled Receptor 68,Inhibitor,TGF-β,inhibit,fibroblasts,fibrotic diseases,Ogerin,GPR68,HEK293,A2A
- CBNumber:
- CB34670516
- Molecular Formula:
- C17H17N5O
- Molecular Weight:
- 307.35
- MDL Number:
- MOL File:
- 1309198-71-7.mol
- MSDS File:
- SDS
Ogerin price More Price(5)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | SML1482 | Ogerin ≥98% (HPLC) | 1309198-71-7 | 5MG | $105 | 2023-06-20 | Buy |
Sigma-Aldrich | SML1482 | Ogerin ≥98% (HPLC) | 1309198-71-7 | 25MG | $424 | 2023-06-20 | Buy |
Tocris | 5722 | Ogerin ≥98%(HPLC) | 1309198-71-7 | 50 | $724 | 2021-12-16 | Buy |
Tocris | 5722 | Ogerin ≥98%(HPLC) | 1309198-71-7 | 10 | $173 | 2021-12-16 | Buy |
TRC | O990035 | Ogerin | 1309198-71-7 | 1mg | $95 | 2021-12-16 | Buy |
Ogerin Chemical Properties,Uses,Production
Uses
Ogerin is a potent GPR68 modulator.
Biochem/physiol Actions
Ogerin is a selective positive allosteric modulator of an orphan GPCR, GPR68, also known as Ovarian cancer G-protein coupled receptor 1 (OGR1). GPR68 is one of the proton or pH-sensing GPCRs that sense extracellular H(+). Ogerin potently potentiated proton-mediated GPR68-Gs signaling. Ogerin was not active in GPR68 knockout mice, but was found to suppress recall in fear conditioning in wild-type mice, showing an unexpected effect of GPR68 on learning and memory.
Enzyme inhibitor
This GPR68 activator (FW = 307.35 g/mol; CAS 1309198-71-7), also named 2-[4-amino-6-[(phenylmethyl)amino]-1,3,5-triazin-2-yl]benzenemethanol, selectively and allosterically targets G-Protein-coupled Receptor 68, one of at least 120 non-olfactory G-protein-coupled receptors in the human genome that remain 'orphans' (i.e., they are pharmacologically dark, with no known endogenous ligands). Ogerin suppresses recall in fear conditioning in wild-type, but not in GPR68-knockout mice. GPR68 is also a newly recognized metastasis suppressor gene in certain cancers.
storage
Store at -20°C
Ogerin Preparation Products And Raw materials
Raw materials
Preparation Products
Ogerin Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9806 | 58 |
BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9412 | 58 |
Shanghai hongqu biomedical technology co. LTD | 88888888888 | hongquchem@qq.com | China | 5132 | 58 |
Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |
Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; | psaitong@jm-bio.com | China | 29778 | 58 |
TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24647 | 58 |