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BPKDi
- CAS No.
- 1201673-28-0
- Chemical Name:
- BPKDi
- Synonyms
- BPKDi;[2,4'-Bipyridine]-4-carboxamide, 2'-(cyclohexylamino)-6-(1-piperazinyl)-
- CBNumber:
- CB34718593
- Molecular Formula:
- C21H28N6O
- Molecular Weight:
- 380.49
- MDL Number:
- MFCD28160405
- MOL File:
- 1201673-28-0.mol
Last updated:2024-10-28 23:16:16
BPKDi Chemical Properties,Uses,Production
Biological Activity
BPKDi is an inhibitor of protein kinase D (PKD; IC50s = 1, 9, and 1 nM for PKD1, PKD2, and PKD3, respectively).1 It is selective for PKD over PKCδ and PKCε, as well as over a panel of additional calcium/calmodulin-dependent protein kinase (CaMK) superfamily members, at 1 μM. It inhibits phenylephrine-induced phosphorylation and nuclear export of histone deacetylase 4 (HDAC4) and HDAC5 in, as well reduces phenylephrine-induced hypertrophy of, isolated neonatal rat ventricular myocytes when used at a concentration of 1 μM.
References
1.Monovich, L., Vega, R.B., Meredith, E., et al.A novel kinase inhibitor establishes a predominant role for protein kinase D as a cardiac class IIa histone deacetylase kinaseFEBS Lett.584(3)631-637(2010)
BPKDi Preparation Products And Raw materials
Raw materials
Preparation Products
BPKDi Suppliers
Global( 10)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9806 | 58 |
ShangHai ChuanQian Chemcial Technique Centre | 15869524721 | 3525679403@qq.com | China | 4012 | 58 |
Jinan Jiuli Biotechnology Co. , Ltd. | 15865264761 | 486064515@qq.com | China | 4542 | 58 |
ChemeGen 中国 | 18818260767 | 2625930290@qq.com | China | 6973 | 58 |
Beijing Biocreative Technology Co., Ltd. | 15522676233 | 3007606172@qq.com | China | 1248 | 58 |
TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24644 | 58 |
Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 4988 | 58 |
Baoji Didu Pharmaceutical and Chemical Co., Ltd | 02961856358 15829046862 | 1035@dideu.com | China | 10010 | 58 |
BPKDi
[2,4'-Bipyridine]-4-carboxamide, 2'-(cyclohexylamino)-6-(1-piperazinyl)-
1201673-28-0