GPI-16552 (GPI16552)
- CAS No.
- 443794-40-9
- Chemical Name:
- GPI-16552 (GPI16552)
- Synonyms
- GPI 16552;GPI-16552 (GPI16552);9H-Fluorene-2,7-dicarboxamide, 9-oxo-N2,N7-bis(3-phenylpropyl)-
- CBNumber:
- CB34844816
- Molecular Formula:
- C33H30N2O3
- Molecular Weight:
- 502.6
- MDL Number:
- MOL File:
- 443794-40-9.mol
| Boiling point | 763.2±60.0 °C(Predicted) |
|---|---|
| Density | 1.217±0.06 g/cm3(Predicted) |
| storage temp. | RT |
| solubility | Soluble in DMSO (up to 25 mg/ml) or in DMF (up to 25 mg/ml). |
| form | solid |
| pka | 11.45±0.20(Predicted) |
| color | Pale yellow |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20° for up to 3 months. |
| FDA UNII | AB6W7KP8MX |
GPI-16552 (GPI16552) Chemical Properties,Uses,Production
Description
GPI-16552 (443794-40-9) is a novel potent inhibitor of poly(ADP-ribose) glycohydrolase (PARG), IC50=1.7 μM.1 Pre or post ischemia treatment (40 mg/kg) with GPI-16552 reduces brain infarct volumes in a rat model of cerebral ischemia.2?It modulates the inflammatory response to ischemia/reperfusion in a rat splanchnic artery occlusion model3?and reduces the degree of spinal cord inflammation and tissue injury after experimental spinal cord trauma4. GPI-16552 synergizes with temozolomide in decreasing melanoma cell invasion and metastatic spreading in mice injected with B16 melanoma cells.5
Uses
GPI 16552 is a a novel PARG inhibitor that ameliorates ischemic brain damage in rat.
References
1) Zhang?et al. (2002),?PARP and PARG as novel therapeutic targets; Drugs Future,?27?371 2) Lu?et al. (2003),?Post-treatment with a novel PARG inhibitor reduces infarct in cerebral ischemia in the rat; Brain Res.,978?99 3) Cuzzocrea?et al. (2005),?PARG activity mediates intestinal injury induced by splanchnic artery occlusion and reperfusion; FASEB J.,?19?558 4) Cuzzocrea?et al. (2006),?Poly(ADP-ribose) glycohydrolase activity mediates post-traumatic inflammatory reaction after experimental spinal cord trauma; J. Pharmacol. Exp. Ther.,?319?127 5) Tentori?et al. (2005),?Poly(ADP-ribose) glycohydrolase inhibitor as chemosensitiser of malignant melanoma for temozolomide; Eur. J. Cancer,?41?2948
GPI-16552 (GPI16552) Preparation Products And Raw materials
Raw materials
Preparation Products
GPI-16552 (GPI16552) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Focus Biomolecules | -- | sales@focusbiomolecules.com | United States | 1284 | 58 |
| Supplier | Advantage |
|---|---|
| Focus Biomolecules | 58 |