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NEMONAPRIDE

NEMONAPRIDE Structure
NEMONAPRIDE structure
CAS No.
75272-39-8
Chemical Name:
NEMONAPRIDE
Synonyms
C12915;Emilace;ym-09151;emonapride;YM 09151-2;NEMONAPRIDE;nobenzamide;inobenzamide;(2R,3R)-nemonapride;cis-(+-)-rrolidinyl)
CBNumber:
CB3492220
Molecular Formula:
C21H26ClN3O2
Molecular Weight:
387.9
MDL Number:
MFCD00902138
MOL File:
75272-39-8.mol
Last updated:2024-10-28 16:48:35
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NEMONAPRIDE Properties

Melting point 152-153°C
storage temp. Store at RT
solubility Chloroform (Slightly), Methanol (Slightly)
form Solid
color White to Off-White
CAS DataBase Reference 75272-39-8
FDA UNII Q88T5P3444

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P330-P501
NFPA 704
0
2 0

NEMONAPRIDE price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 21376 Nemonapride ≥98% 75272-39-8 1mg $44 2024-03-01 Buy
Cayman Chemical 21376 Nemonapride ≥98% 75272-39-8 5mg $140 2024-03-01 Buy
Cayman Chemical 21376 Nemonapride ≥98% 75272-39-8 10mg $214 2024-03-01 Buy
Cayman Chemical 21376 Nemonapride ≥98% 75272-39-8 50mg $844 2024-03-01 Buy
Tocris 1746 Nemonapride ≥99%(HPLC) 75272-39-8 10 $212 2021-12-16 Buy
Product number Packaging Price Buy
21376 1mg $44 Buy
21376 5mg $140 Buy
21376 10mg $214 Buy
21376 50mg $844 Buy
1746 10 $212 Buy

NEMONAPRIDE Chemical Properties,Uses,Production

Description

Nemonapride is a potent dopamine D2receptor antagonist antipsychotic reported to have superior efficacy against hallucinations and delusions and also to be effective in the treatment of negative symptoms. The compound is a benzamide diastereomer and, although more potent than haloperidol, side effects are reported to be few primarily akinesia and some muscle rigidity with extrapyramidal symptoms being rare.

Description

Nemonapride is an antipsychotic that readily passes through the blood brain barrier and exhibits potent neuroleptic effects in animals. It binds dopamine 2 (D2)-like receptors preferentially over D1-like receptors (Kis = 0.06, 0.3, and 0.15 nM for D2, D3, and D4, respectively). Nemonapride also binds sigma 1 (σ1) and σ2 receptors (Kis = 8.4 and 9.6 nM, respectively) and activates the serotonin 1A receptor (5-HT1A; IC50 = 34 nM).

Chemical Properties

Colourless Crystalline Solid

Originator

Yamanouchi (Japan)

Uses

Nemonapride is a selective dopamine D2 receptor antagonist. Nemonapride is used as an antipsychotic.

Uses

A selective dopamine D2 receptor antagonist. Used as an antipsychotic

Definition

ChEBI: (2R,3R)-nemonapride is an optically active form of nemonapride having (2R,3R)-configuration. It is a conjugate base of a (2R,3R)-nemonapride(1+). It is an enantiomer of a (2S,3S)-nemonapride.

brand name

Emirace

Biological Activity

Highly potent dopamine D 2 -like receptor antagonist; selective over D 1 -like receptors (K i values are 0.1 and 740 nM for D 2 -like and D 1 -like receptors respectively). Also potent 5-HT 1A receptor agonist (IC 50 = 34 nM) and has affinity for sigma receptors.

storage

Store at RT

NEMONAPRIDE Preparation Products And Raw materials

Raw materials

Ethyl chloroformate Hydroxylamine hydrochloride Nemonapride

Preparation Products

NEMONAPRIDE Suppliers

Global( 47)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32165 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207 sales@molcore.com China 49734 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 52925 58
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788 jkinfo@jkchemical.com China 94657 76
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15839 69
LGM Pharma 1-(800)-881-8210 inquiries@lgmpharma.com United States 2123 70
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32321 50
EMMX Biotechnology LLC 888-539-0666 info@emmx.com United States 8447 60
Shenzhen Polymeri Biochemical Technology Co., Ltd. +86-400-002-6226 +86-13028896684; sales@rrkchem.com China 57412 58
BOC Sciences -- info@bocsci.com USA 0 65
Supplier Advantage
TargetMol Chemicals Inc. 		58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		58
Aladdin Scientific 		58
J & K SCIENTIFIC LTD. 76
3B Pharmachem (Wuhan) International Co.,Ltd. 69
LGM Pharma 70
Chemsky（shanghai）International Co.,Ltd. 50
EMMX Biotechnology LLC 60
Shenzhen Polymeri Biochemical Technology Co., Ltd. 58
BOC Sciences 65

View Lastest Price from NEMONAPRIDE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Nemonapride pictures 2024-10-28 Nemonapride
75272-39-8
 US $110.00-535.00 / mg 10g TargetMol Chemicals Inc.
  • Nemonapride pictures
  • Nemonapride
    75272-39-8
  • US $110.00-535.00 / mg
  • TargetMol Chemicals Inc.

75272-39-8(NEMONAPRIDE)Related Search:

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(R)-(+)-BENZYL-3-ACETYLAMINOPYRROLIDINE& NEMONAPRIDE (3R)-(-)-1-BENZYL-3-(METHYLAMINO)PYRROLIDINE (S)-(+)-1-Benzyl-3-aminopyrrolidine (3R)-(+)-3-(METHYLAMINO)PYRROLIDINE
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CIS-5-CHLORO-2-METHOXY-4-(METHYLAMINO)-N-[2-METHYL-1-(PHENYLMETHYL)-3-PYRROLIDINYL]BENZAMIDE REL-5-CHLORO-2-METHOXY-4-(METHYLAMINO)-N-[(2R,3R)-2-METHYL-2-(PHENNYLMETHYL)-3-PYRROLIDINYL]BENZAMIDE NEMONAPRIDE (+-)-cis-n-(1-benzyl-2-methylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-methylami benzamide,5-chloro-2-methoxy-4-(methylamino)-n-(2-methyl-1-(phenylmethyl)-3-py cis-(+-)-rrolidinyl) emonapride inobenzamide n-(2rs,3rs)-(1-benzyl-2-methyl-3-pyrrolidinyl)-5-chloro-2-methoxy-4-methylam nobenzamide ym-09151 Benzamide, 5-chloro-2-methoxy-4-(methylamino)-N-[(2R,3R)-2-methyl-1-(phenylmethyl)-3-pyrrolidinyl]-, rel- (9CI) Benzamide, 5-chloro-2-methoxy-4-(methylamino)-N-[2-methyl-1-(phenylmethyl)-3-pyrrolidinyl]-, cis- Emilace YM 09151-2 N-[(2R,3R)-1-Benzyl-2-methylpyrrolidine-3-yl]-2-methoxy-4-(methylamino)-5-chlorobenzamide C12915 cis-5-Chloro-2-Methoxy-4-(MethylaMino)-N-[2-Methyl-1- (phennylMethyl)-3-pyrrolidinyl]benzaMide rel-5-Chloro-2-Methoxy-4-(MethylaMino)-N-[(2R,3R)-2-Methyl-1-(phennylMethyl)-3-pyrrolidinyl]benzaMide cis-5-Chloro-2-methoxy-4-(methylamino)-N-[2-methyl-2-(phenylmethyl)-3-pyrrolidinyl]benzamide (2R,3R)-nemonapride N-(Cis-1-benzyl-2-methylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-(methylamino)benzamide 75272-39-8 C21H26Cl23O2 Aromatics Heterocycles Heterocyclic Compounds Intermediates & Fine Chemicals Neurochemicals Pharmaceuticals Dopamine receptor