NANAOMYCIN A
- CAS No.
- 52934-83-5
- Chemical Name:
- NANAOMYCIN A
- Synonyms
- os-3966-a;Nanaomycin;rosanomycina;heptauromycin;(1s-e)-10-dioxo;OS-3966-A; ROSANOMYCINA;1h-naphtho(2,3-c)pyran-3-aceticacid,3,4,5,10-tetrahydro-9-hydroxy-1-methyl-5,;(1S)-3,4,5,10-Tetrahydro-9-hydroxy-1-methyl-5,10-dioxo-1H-naphtho[2,3-c]pyran-3β-acetic acid;(1S,3R)-3,4,5,10-Tetrahydro-9-hydroxy-1-methyl-5,10-dioxo-1H-naphtho[2,3-c]pyran-3-acetic acid;Antibiotic OS 3966A, Nanafrocin, 1H-Naphtho[2,3-c]pyran-3-acetic acid,3,4,5,10-tetrahydro-9-hydroxy-1-methyl-5,10-dioxo-(1S,3R)-
- CBNumber:
- CB3503991
- Molecular Formula:
- C16H14O6
- Molecular Weight:
- 302.28
- MDL Number:
- MFCD00869168
- MOL File:
- 52934-83-5.mol
- MSDS File:
- SDS
| Melting point | 179°C |
|---|---|
| Boiling point | 363.32°C (rough estimate) |
| Density | 1.2514 (rough estimate) |
| refractive index | 1.4600 (estimate) |
| storage temp. | −20°C |
| solubility | insoluble in H2O; ≥15.1 mg/mL in DMSO; ≥31.07 mg/mL in EtOH with ultrasonic |
| form | solid |
| color | Yellow to orange |
| FDA UNII | 8XBV72641V |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H310-H301 | |||||||||
| Precautionary statements | P262-P264-P270-P280-P302+P350-P310-P322-P361-P363-P405-P501-P264-P270-P301+P310-P321-P330-P405-P501 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 22-24 | |||||||||
| Safety Statements | 36/37-45 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | QL6127000 | |||||||||
| NFPA 704 |
|
NANAOMYCIN A price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ApexBio Technology | A8191 | NanaomycinA | 52934-83-5 | 10mM(in 1mL DMSO) | $340 | 2021-12-16 | Buy |
| ApexBio Technology | A8191 | NanaomycinA | 52934-83-5 | 5mg | $350 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0010483 | 1H-NAPHTHO[2,3-C]PYRAN-3-ACETIC ACID, 3,4,5,10-TETRAHYDRO-9-HYDROXY-1-METHYL-5,10-DIOXO-(1S,3R)- 95.00% | 52934-83-5 | 5MG | $500.38 | 2021-12-16 | Buy |
| ApexBio Technology | A8191 | NanaomycinA | 52934-83-5 | 25mg | $1000 | 2021-12-16 | Buy |
| ChemScene | CS-0027820 | NanaomycinA ≥98.0% | 52934-83-5 | 5mg | $1050 | 2021-12-16 | Buy |
NANAOMYCIN A Chemical Properties,Uses,Production
Definition
ChEBI: A pyranonaphthoquinone antibiotic from strain OS-3966 of Streptomyces rosa var. notoensis.
Biological Activity
nanaomycin a is a selective inhibitor of dna methyltransferase 3b (dnmt3b) with ic50 value of 500 nm [1].in the biochemical in vitro methylation assay, nanaomycin a showed selective inhibition of dnmt3b but not dnmt1 although it was docked to the catalytic domain of human dnmt1 in a multi-step docking approach. nanaomycin a showed cell viability inhibition in hct116, a549 and hl60 cells with ic50 values of 400 nm, 4100 nm and 800 nm, respectively. it decreased the genomic methylation level of these cells significantly. besides that, nanaomycin a treatment resulted in demethylation of the rassf1a promoter in a549 cells. the demethylation caused by nanaomycin a reactivated the transcription and expression of a silenced tumor suppressor gene [1].
target
DNMT3B
References
[1] kuck d, caulfield t, lyko f, et al. nanaomycin a selectively inhibits dnmt3b and reactivates silenced tumor suppressor genes in human cancer cells. molecular cancer therapeutics, 2010, 9(11): 3015-3023.
NANAOMYCIN A Preparation Products And Raw materials
Raw materials
Preparation Products
NANAOMYCIN A Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
| Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | +86-18791163155 +86-13119157289 | 13119157289@163.com | China | 2973 | 58 |
| Hangzhou Yuhao Chemical Technology Co., Ltd | 0571-82693216 | info@yuhaochemical.com | China | 9387 | 52 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14055 | 65 |
| Alta Scientific Co., Ltd. | 022-6537-8550 15522853686 | sales@altasci.com.cn | China | 4511 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9806 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 | psaitong@jm-bio.com | China | 12306 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| Absin Bioscience Inc. | 021-38015121 15000105423 | wulan@absin.cn | China | 24731 | 58 |
View Lastest Price from NANAOMYCIN A manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | Nanaomycin A
52934-83-5
|
US $1380.00-370.00 / mg | 10g | TargetMol Chemicals Inc. |
-
- Nanaomycin A
52934-83-5
- US $1380.00-370.00 / mg
- TargetMol Chemicals Inc.