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SU 11274

SU 11274 Structure
SU 11274 structure
CAS No.
658084-23-2
Chemical Name:
SU 11274
Synonyms
1H-Indole-5-sulfonamide, N-(3-chlorophenyl)-3-[[3,5-dimethyl-4-[(4-methyl-1-piperazinyl)carbonyl]-1H-pyrrol-2-yl]methylene]-2,3-dihydro-N-methyl-2-oxo-, (3Z)-;Sul1274;PKI-SU11274;SU 11274, >=98%;SU 11274，SU 11274;SU 11274 USP/EP/BP;SU11274(PKI-SU11274);Met Kinase Inhibitor;SU-11274;PKI-SU11274;SU 11274;Met Kinase Inhibitor SU11274 SU-11274
CBNumber:
CB3504776
Molecular Formula:
C28H30ClN5O4S
Molecular Weight:
568.09
MDL Number:
MFCD08276928
MOL File:
658084-23-2.mol
MSDS File:
SDS
Last updated:2023-06-08 09:02:14
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SU 11274 Properties

Density 1.401±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: 10 mg/mL at 60 °C
pka 11.62±0.20(Predicted)
form powder
color orange
InChIKey FPYJSJDOHRDAMT-KQWNVCNZSA-N

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H335-H315-H319
Precautionary statements  P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
NFPA 704
0
2 0

SU 11274 price More Price(20)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 448101 Met Kinase Inhibitor 658084-23-2 1mg $154 2023-06-20 Buy
Cayman Chemical 14861 SU 11274 ≥95% 658084-23-2 500μg $44 2024-03-01 Buy
Cayman Chemical 14861 SU 11274 ≥95% 658084-23-2 1mg $84 2024-03-01 Buy
Sigma-Aldrich S9820 SU 11274 ≥98% (HPLC), powder 658084-23-2 25mg $921 2022-05-15 Buy
Cayman Chemical 14861 SU 11274 ≥95% 658084-23-2 5mg $130 2024-03-01 Buy
Product number Packaging Price Buy
448101 1mg $154 Buy
14861 500μg $44 Buy
14861 1mg $84 Buy
S9820 25mg $921 Buy
14861 5mg $130 Buy

SU 11274 Chemical Properties,Uses,Production

Description

MET is a proto-oncogene which encodes the hepatocyte growth factor receptor c-Met. It has normal roles in morphogenesis, migration, apoptosis, and angiogenesis. Dysregulation of c-Met occurs in many types of cancer. SU11274 is a potent, selective, ATP-competitive inhibitor of c-Met (IC50 = 20 nM). It has much less or no activity against other receptor tyrosine kinases. SU11274 induces apoptosis and cell cycle arrest in transformed Ba/F3 cells and cancer cell lines.

Uses

SU 11274 is a competitive inhibitor of Met kinase activity.

Definition

ChEBI: 1h-indole-5-sulfonamide, n-(3-chlorophenyl)-3-[[3,5-dimethyl-4-[(4-methyl-1-piperazinyl)carbonyl]-1h-pyrrol-2-yl]methylene]-2,3-dihydro-n-methyl-2-oxo-, (3z)- is a sulfonamide.

Biochem/physiol Actions

SU 11274 is a class I c-Met inhibitor that competes with ATP to bind to the activation loop of c-Met.1 Inhibition of c-Met by SU 11274 is effective in improving the clinical outcome in non-small cell lung cancer cell lines.2

References

[1] wang x1, le p, liang c, chan j, kiewlich d, miller t, harris d, sun l, rice a, vasile s, blake ra, howlett ar, patel n, mcmahon g, lipson ke. potent and selective inhibitors of the met [hepatocyte growth factor/scatter factor (hgf/sf) receptor] tyrosine kinase block hgf/sf-induced tumor cell growth and invasion. mol cancer ther. 2003 nov;2(11):1085-92.
[2] leiser d1, pochon b1, blank-liss w1, francica p1, glück aa1, aebersold dm1, zimmer y1, medová m2. targeting of the met receptor tyrosine kinase by small molecule inhibitors leads to met accumulation by impairing the receptor downregulation. febs lett. 2014 mar 3;588(5):653-8.

SU 11274 Preparation Products And Raw materials

Raw materials

Preparation Products

SU 11274 Suppliers

Global( 125)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29791 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32957 60
Biochempartner 		0086-13720134139 candy@biochempartner.com CHINA 965 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49374 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29811 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 22783 58
Hefei Hirisun Pharmatech Co., Ltd 		+8615056975894 shawn@hirisunpharm.com CHINA 9911 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
Nantong HI-FUTURE Biology Co., Ltd. 		+undefined18051384581 sales@chemhifuture.com China 3135 58
Supplier Advantage
Capot Chemical Co.,Ltd. 		60
ATK CHEMICAL COMPANY LIMITED 		60
Biochempartner 		58
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
Dideu Industries Group Limited 		58
Hefei Hirisun Pharmatech Co., Ltd 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
InvivoChem 		58
Nantong HI-FUTURE Biology Co., Ltd. 		58

View Lastest Price from SU 11274 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(3Z)-N-(3-chlorophenyl)-3-[[3,5-dimethyl-4-(4-methylpiperazine-1-carbonyl)-1H-pyrrol-2-yl]methylidene]-N-methyl-2-oxo-1H-indole-5-sulfonamide pictures 2019-12-24 (3Z)-N-(3-chlorophenyl)-3-[[3,5-dimethyl-4-(4-methylpiperazine-1-carbonyl)-1H-pyrrol-2-yl]methylidene]-N-methyl-2-oxo-1H-indole-5-sulfonamide
658084-23-2
 US $1.00 / KG 1KG Min98% HPLC g/kg/ton Career Henan Chemical Co
(3Z)-N-(3-chlorophenyl)-3-[[3,5-dimethyl-4-(4-methylpiperazine-1-carbonyl)-1H-pyrrol-2-yl]methylidene]-N-methyl-2-oxo-1H-indole-5-sulfonamide pictures 2019-12-23 (3Z)-N-(3-chlorophenyl)-3-[[3,5-dimethyl-4-(4-methylpiperazine-1-carbonyl)-1H-pyrrol-2-yl]methylidene]-N-methyl-2-oxo-1H-indole-5-sulfonamide
658084-23-2
 US $1.00 / KG 1KG Min98% HPLC g/kg/ton Career Henan Chemical Co

658084-23-2(SU 11274)Related Search:

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1of4

PKI-SU11274 N-(3-Chlorophenyl)-N-methyl-3-[[3,5-dimethyl-4-[(4-methylpiperazin-1-yl)carbonyl]-1H-pyrrol-2-yl]methylene]-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide N-(3-Chlorophenyl)-N-methyl-3-[[3,5-dimethyl-4-[(4-methylpiperazin-1-yl)carbonyl]-1H-pyrrol-2-yl]methylene]-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide SU11274 SU 11274, >=98% Met Kinase Inhibitor (Z)-N-(3-Chlorophenyl)-3-((3,5-dimethyl-4-(4-methylpiperazine-1-carbonyl)-1H-pyrrol-2-yl)methy (3z)-n-(3-chlorophenyl)-3-({3,5-dimethyl-4-[(4-methylpiperazin-1-yl)carbonyl]-1h-pyrrol-2-yl}methylene)-n-methyl-2-oxo-2,3-dihydro-1h-indole-5-sulfonamide SU 11274，SU 11274 (Z)-N-(3-chlorophenyl)-3-((3,5-diMethyl-4-(4-Methylpiperazine-1-carbonyl)-1H-pyrrol-2-yl)Methylene)-N-Methyl-2-oxoindoline-5-sulfonaMide SU11274(PKI-SU11274) Sul1274 (Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-(1-methylpiperazine-4-carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxoindoline-5-sulfonamide (3Z)-N-(3-chlorophenyl)-3-[[3,5-dimethyl-4-(4-methylpiperazine-1-carbonyl)-1H-pyrrol-2-yl]methylidene]-N-methyl-2-oxo-1H-indole-5-sulfonamide (3Z)-N-(3-Chlorophenyl)-3-[[3,5-dimethyl-4-[(4-methyl-1-piperazinyl)carbonyl]-1H-pyrrol-2-yl]methylene]-2,3-dihydro-N-methyl-2-oxo-1H-indole-5-sulfonamide Met Kinase Inhibitor - CAS 658084-23-2 - Calbiochem SU-11274;PKI-SU11274;SU 11274 SU 11274 USP/EP/BP 1H-Indole-5-sulfonamide, N-(3-chlorophenyl)-3-[[3,5-dimethyl-4-[(4-methyl-1-piperazinyl)carbonyl]-1H-pyrrol-2-yl]methylene]-2,3-dihydro-N-methyl-2-oxo-, (3Z)- Met Kinase Inhibitor SU11274 SU-11274 SU 11274,Inhibitor,Autophagy,inhibit,c-Met/HGFR,Apoptosis,SU-11274,SU11274 658084-23-2 C28H30ClN5O4S C28H30CIN5O4S C28Cl1H30N5O4S1 Inhibitors