(1S,4S,5S)-4-Bromo-6-oxabicyclo[3.2.1]octan-7-one
![(1S,4S,5S)-4-Bromo-6-oxabicyclo[3.2.1]octan-7-one Structure](CAS/20200515/GIF/139893-81-5.gif)
- CAS No.
- 139893-81-5
- Chemical Name:
- (1S,4S,5S)-4-Bromo-6-oxabicyclo[3.2.1]octan-7-one
- Synonyms
- (1S,4S,5S)-4-bromo-6-oxabicyclo[3.2.1]octan-7-one;Edoxaban Impurity 80;6-Oxabicyclo[3.2.1]octan-7-one, 4-bromo-, (1S-exo)- (9CI);(1S,4S,5S)-4-Bromo-6-oxabicyclo[3.2.1]octan-7-oneQ: What is (1S,4S,5S)-4-Bromo-6-oxabicyclo[3.2.1]octan-7-one Q: What is the CAS Number of (1S,4S,5S)-4-Bromo-6-oxabicyclo[3.2.1]octan-7-one
- CBNumber:
- CB35925598
- Molecular Formula:
- C7H9BrO2
- Molecular Weight:
- 205.05
- MDL Number:
- MOL File:
- 139893-81-5.mol
(1S,4S,5S)-4-Bromo-6-oxabicyclo[3.2.1]octan-7-one Chemical Properties,Uses,Production
Uses
Used as Edoxaban impurity.
Synthesis
(1S)-Cyclohex-3-ene-1-carboxylic acid (II) (5 g) was dissolved in dichloromethane (25 mL). To this solution, N-bromosuccinimide (1.1 mole) was added at room temperature. In two lots, calcium oxide (0.25 mole) was charged to the Suspension. The reaction mixture was stirred at 20 to 25°C for 1 hour and filtered. The bed was washed with dichloromethane (10 mL). The washings were combined with the filtrate, and the solvent was recovered under vacuum at 35 to 40 °C. Deionized water (50 mL) was charged to the solid, heated to 50 °C, stirred for 10 minutes, and filtered. The bed was washed with deionized water (10 mL) and suction dried. The solid was dried under vacuum at 45-50 °C to get (1S,4S,5S)-4-Bromo-6-oxabicyclo[3.2.1]octan-7-one. Yield: 61%
(1S,4S,5S)-4-Bromo-6-oxabicyclo[3.2.1]octan-7-one Preparation Products And Raw materials
(1S,4S,5S)-4-Bromo-6-oxabicyclo[3.2.1]octan-7-one Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Eaglech（shanghai）Pharmaceutical Co., Ltd | +86-2160290089 +86-13884467586 | eagpharm@gmail.com | China | 90 | 58 |
| Changzhou Guiding Bio-Tech. Co.,Ltd. | +86-519-519-86686860 +8618795626222 | ning@guiding-bio.com | China | 299 | 58 |
| China National Standard Pharmaceutical Corporation Limited | +8615391658522 | overseasales@yongstandards.com | China | 11922 | 58 |
| Wuhan Fortuna Chemical Co.,Ltd | +8618007136271 | hk@fortunachem.com | China | 5998 | 58 |
| Watson Biotechnology Co.,Ltd | +86-18186686046 +86-18186686046 | sales01@watsonbiotech.cn | China | 5853 | 58 |
| FarmaSino Pharmaceuticals (Jiangsu) Co.,Ltd | 25-8690-7345 18651693585 | zfx@farmasino.com | China | 129 | 58 |
| Jinan Chenghui Shuangda biological Co., LTD | 0531-58897003 15550412551 | market@jnchsd.com | China | 217 | 62 |
| Shanghai Kewel Chemical Co., Ltd. | 021-64609169 18901607656 | greensnown@163.com | China | 9906 | 50 |
| Anqing CHICO Pharmaceutical Co., Ltd. | 13585175604 | sales@chicopharm.com | China | 460 | 65 |
| ChengDu TongChuangYuan Pharmaceutical Co.Ltd | 028-83379370 13880556291 | tcy@tcypharm.com | China | 6273 | 58 |