4-(3-(3,4-dimethoxyphenethylamino)-2- -hydroxypropoxy)benzene-1,2-diol hydrochloride
- CAS No.
- 250580-70-2
- Chemical Name:
- 4-(3-(3,4-dimethoxyphenethylamino)-2- -hydroxypropoxy)benzene-1,2-diol hydrochloride
- Synonyms
- Ro 363 hydrochloride;4-(3-(3,4-dimethoxyphenethylamino)-2- -hydroxypropoxy)benzene-1,2-diol hydrochloride
- CBNumber:
- CB35985051
- Molecular Formula:
- C19H26ClNO6
- Molecular Weight:
- 399.87
- MDL Number:
- MOL File:
- 250580-70-2.mol
4-(3-(3,4-dimethoxyphenethylamino)-2- -hydroxypropoxy)benzene-1,2-diol hydrochloride Chemical Properties,Uses,Production
Uses
Ro 363 hydrochloride, an effective inotropic stimulant, is a potent and highly selective β1-adrenoceptor agonist. Ro 363 hydrochloride is a cardiovascular modulator that reduces diastolic blood pressure and pronounces increases in myocardial contractility[1][2][3].
in vivo
In chloralose-anaesthetized cats, Ro 363, when compared to epinephrine (adrenaline), is essentially devoid of arrhythmogenic activity in animals in which cardiac sensitization is induced by U-0882 or halothane[1].
IC 50
β adrenergic receptor
References
[1] Maccarrone C, et al. Comparison of the Arrhythmogenic Actions of (-)-Isoprenaline, Dobutamine and the selective beta 1-adrenoceptor agonist, (+/-)-(1-[3',4'-dihydroxyphenoxy] -2-hydroxy-[3",4"-dimethoxy phenethylamino]-propane)-oxalate (Ro 363). Arzneimittelforschung. 1985;35(3):592-8. PMID:2859864
[2] Iakovidis D, et al. In vitro activity of RO363, a beta1-adrenoceptor selective agonist. Br J Pharmacol. 1980 Apr;68(4):677-85. DOI:10.1111/j.1476-5381.1980.tb10860.x
[3] Einstein R, et al. Comparison of the cardiac effects of beta-adrenoreceptor agonists in anaesthetised and conscious dogs. J Auton Pharmacol. 1986 Mar;6(1):9-14. DOI:10.1111/j.1474-8673.1986.tb00625.x
4-(3-(3,4-dimethoxyphenethylamino)-2- -hydroxypropoxy)benzene-1,2-diol hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
4-(3-(3,4-dimethoxyphenethylamino)-2- -hydroxypropoxy)benzene-1,2-diol hydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38630 | 58 | |
| Shanghai ChuangYan Chemical Technology Co., Ltd. | 021-11111111 11111111111 | 546919421@qq.com | China | 3333 | 55 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; | psaitong@jm-bio.com | China | 29774 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 19699 | 58 |
View Lastest Price from 4-(3-(3,4-dimethoxyphenethylamino)-2- -hydroxypropoxy)benzene-1,2-diol hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-10-28 | Ro 363 hydrochloride
250580-70-2
|
US $996.00 / mg | 10g | TargetMol Chemicals Inc. |
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- Ro 363 hydrochloride
250580-70-2
- US $996.00 / mg
- TargetMol Chemicals Inc.