Betamethasone 17,21-dipropionate
- CAS No.
- 5593-20-4
- Chemical Name:
- Betamethasone 17,21-dipropionate
- Synonyms
- BETAMETHASONE DIPROPIONATE;BetaMethasone dipropionat;diprolene;diprosone;Betamethasone 17;S 3440;Psorion;Maxivate;diprosis;Diprophos
- CBNumber:
- CB3676725
- Molecular Formula:
- C28H37FO7
- Molecular Weight:
- 504.6
- MDL Number:
- MFCD00072035
- MOL File:
- 5593-20-4.mol
- MSDS File:
- SDS
Melting point | 178 °C |
---|---|
alpha | D26 +65.7° (dioxane) |
Boiling point | 603.2±55.0 °C(Predicted) |
Density | 1.1481 (estimate) |
refractive index | 69 ° (C=1, Dioxane) |
storage temp. | 2-8°C |
solubility | Practically insoluble in water, freely soluble in acetone and in methylene chloride, sparingly soluble in ethanol (96 per cent). |
form | Solid |
pka | 12.87±0.70(Predicted) |
color | White to Pale Yellow |
Merck | 1180 |
InChIKey | CIWBQSYVNNPZIQ-JCOVECCMSA-N |
SMILES | C([C@]1([C@H](C[C@@]2([H])[C@]3([H])CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C)C)OC(=O)CC)(=O)COC(=O)CC |&1:1,2,4,6,16,18,20,23,r| |
CAS DataBase Reference | 5593-20-4(CAS DataBase Reference) |
FDA UNII | 826Y60901U |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS08 |
---|---|
Signal word | Danger |
Hazard statements | H360FD-H373 |
Precautionary statements | P202-P260-P280-P308+P313-P405-P501 |
Safety Statements | 22-24/25 |
WGK Germany | 2 |
RTECS | TU4058000 |
HS Code | 29372290 |
Toxicity | LD50 ipr-mus: 103 mg/kg NIIRDN 6,753,82 |
Betamethasone 17,21-dipropionate price More Price(22)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | B1152 | Betamethasone 17,21-dipropionate ≥97.0% | 5593-20-4 | 1g | $276 | 2024-03-01 | Buy |
Sigma-Aldrich | 1067704 | Betamethasone dipropionate | 5593-20-4 | 125mg | $358 | 2024-03-01 | Buy |
Sigma-Aldrich | Y0001925 | Betamethasone dipropionate for system suitability A European Pharmacopoeia (EP) Reference Standard | 5593-20-4 | Y0001925 | $212 | 2023-06-20 | Buy |
Sigma-Aldrich | Y0001416 | Betamethasone dipropionate for peak identification European Pharmacopoeia (EP) Reference Standard | 5593-20-4 | y0001416 | $220 | 2024-03-01 | Buy |
Sigma-Aldrich | B1152 | Betamethasone 17,21-dipropionate ≥97.0% | 5593-20-4 | 100mg | $53.4 | 2024-03-01 | Buy |
Betamethasone 17,21-dipropionate Chemical Properties,Uses,Production
Chemical Properties
Betamethasone 17,21-dipropionate is Pale Yellow Foam
Originator
Betnovate,Glaxo,UK,1961
Uses
Cortico Steroids
Uses
antiviral
Uses
Betamethasone 17,21-dipropionate is used as anti-inflammatory and antibacterial ointment for dermatosis.
Definition
Betamethasone 17,21-dipropionate is a steroid ester that is betamethasone in which the hydroxy hydrogens at positions 17 and 21 are replaced by propanoyl groups. It is used in combination with calcipotriene hydrate, a synthetic vitamin D analogue, for the topical treatment of plaque psoriasi in adult patients.
Manufacturing Process
A solution of 9α-fluoro-11β-hydroxy-16β-methyl-17α,21-(1'-ethyl-1'-
ethoxymethylenedioxy)pregna-1,4-diene-3,20-dione (538 mg) in acetic acid
(20 ml), containing 2 drops of water, was allowed to stand at room
temperature for 5 hours. Dilution of the mixture with water gave a white solid
(457 mg) which, after being filtered off and dried, was recrystallized from
acetone to afford 9α-fluoro-11β,21-dihydroxy-16β-methyl-17α-
propionyloxypregna-1,4-diene-3, 20-dione (361 mg), MP 230°-235°C.
Bethmethasone 17-propionate (812 mg) in pyridine (10 ml) was treated with
propionyl chloride (0.21 ml) at 0°C for 1 hour. Dilution with water and
acidification with dilute hydrochloric acid gave the crude diester.
Recrystallization from acetone-petroleum ether afforded betamethasone
17,21-dipropionate (649 mg), MP 117°C (decomposition).
brand name
Alphatrex (Savage); Diprolene (Schering).
Therapeutic Function
Glucocorticoid
Biochem/physiol Actions
Betamethasone 17,21-dipropionate is a glucocorticoid with anti-inflammatory and immunosuppressive activity.
Safety Profile
Poison by subcutaneous andintraperitoneal routes. An experimental teratogen. Otherexperimental reproductive effects. When heated todecomposition it emits toxic fumes of F-.
Betamethasone 17,21-dipropionate Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
APOLLO HEALTHCARE RESOURCES | +6596580999 | sales@apollo-healthcare.com.sg | Singapore | 400 | 58 |
Nanjing Shizhou Biotechnology Co., Ltd | +86-15850508050 +86-15850508050 | sean.lv@synzest.com | China | 323 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-29-81148696 +86-15536356810 | 1022@dideu.com | China | 3878 | 58 |
Wuhan Fortuna Chemical Co., Ltd | +86-027-59207850 | info@fortunachem.com | China | 5987 | 58 |
Hebei Dangtong Import and export Co LTD | +86-13910575315 +86-13910575315 | admin@hbdangtong.com | China | 1005 | 58 |
Hebei Kangcang new material Technology Co., LTD | +8615713292910 | Nancy@kangcang.com.cn | China | 341 | 58 |
Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618092446649 | sarah@tnjone.com | China | 1143 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21663 | 55 |
Hubei XinRunde Chemical Co., Ltd. | +8615102730682 | bruce@xrdchem.cn | CHINA | 566 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
View Lastest Price from Betamethasone 17,21-dipropionate manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-09-28 | Betamethasone 17,21-dipropionate
5593-20-4
|
US $10.00-1.00 / kg | 2kg | 99% | 300tons | Hebei Dangtong Import and export Co LTD | ||
2024-09-25 | Betamethasone 17
5593-20-4
|
US $2265.00 / kg | 1kg | 99% HPLC | 20 tons | Wuhan Senwayer Century Chemical Co.,Ltd | ||
2024-09-18 | Betamethasone dipropionate
5593-20-4
|
US $0.00 / Kg/Bag | 1KG | 97%-103%; USP | 100kg | WUHAN FORTUNA CHEMICAL CO., LTD |
- Betamethasone 17,21-dipropionate
5593-20-4
- US $10.00-1.00 / kg
- 99%
- Hebei Dangtong Import and export Co LTD
- Betamethasone 17
5593-20-4
- US $2265.00 / kg
- 99% HPLC
- Wuhan Senwayer Century Chemical Co.,Ltd
- Betamethasone dipropionate
5593-20-4
- US $0.00 / Kg/Bag
- 97%-103%; USP
- WUHAN FORTUNA CHEMICAL CO., LTD