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N,N-DIETHYLNICOTINAMIDE

N,N-DIETHYLNICOTINAMIDE structure

CAS No.: 59-26-7

Chemical Name:: N,N-DIETHYLNICOTINAMIDE

Synonyms: NIKETHAMIDE;Nikotin;CORVOTONE;Tonocard;nicor;Ni-Cor;Ecoran;Corivo;Cormed;Cormid

CBNumber:: CB3677171

Molecular Formula:: C10H14N2O

Molecular Weight:: 178.23

MDL Number:: MFCD00006386

MOL File:: 59-26-7.mol

MSDS File:: SDS

Last updated:2024-11-21 17:11:28

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N,N-DIETHYLNICOTINAMIDE Properties

Melting point	23 °C (lit.)
Boiling point	296-300 °C (lit.)
Density	1.06 g/mL at 25 °C (lit.)
refractive index	n20/D 1.524(lit.)
Flash point	>230 °F
storage temp.	2-8°C
solubility	Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
pka	pKa 3.46(H2O,t =20) (Uncertain)
form	Liquid
color	Clear colorless to yellow
Merck	14,6543
BRN	5743
InChI	InChI=1S/C10H14N2O/c1-3-12(4-2)10(13)9-6-5-7-11-8-9/h5-8H,3-4H2,1-2H3
InChIKey	NCYVXEGFNDZQCU-UHFFFAOYSA-N
SMILES	C1=NC=CC=C1C(N(CC)CC)=O
CAS DataBase Reference	59-26-7(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	368IVD6M32
ATC code	R07AB02,R07AB52
EPA Substance Registry System	Nikethamide (59-26-7)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS06
Signal word	Danger
Hazard statements	H301-H319
Precautionary statements	P264-P270-P280-P301+P310-P305+P351+P338-P337+P313
Hazard Codes	T
Risk Statements	25-36/37/38-23/24/25
Safety Statements	26-45-36/37/39
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS	QS4375000
HazardClass	6.1(b)
PackingGroup	III
HS Code	29333999
Toxicity	LD50 i.p. in rats: 272 mg/kg (Goldenthal)

N,N-DIETHYLNICOTINAMIDE price More Price(17)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	D98807	N,N-Diethylnicotinamide 99%	59-26-7	25g	$62.4	2024-03-01	Buy
Sigma-Aldrich	D98807	N,N-Diethylnicotinamide 99%	59-26-7	100g	$128	2023-06-20	Buy
Sigma-Aldrich	N0800000	Nikethamide European Pharmacopoeia (EP) Reference Standard	59-26-7	n0800000	$220	2024-03-01	Buy
Sigma-Aldrich	D98807	N,N-Diethylnicotinamide 99%	59-26-7	500g	$176	2024-03-01	Buy
Usbiological	459840	N,N-Diethylnicotinamide	59-26-7	2.5g	$403	2021-12-16	Buy

Product number	Packaging	Price	Buy
D98807	25g	$62.4	Buy
D98807	100g	$128	Buy
N0800000	n0800000	$220	Buy
D98807	500g	$176	Buy
459840	2.5g	$403	Buy

N,N-DIETHYLNICOTINAMIDE Chemical Properties,Uses,Production

Description

A further Corydalis alkaloid, coramine has been obtained from C. pseudoadunca M. Pop. It forms colourless needles from EtOH and is optically active with a specific rotation of [α]_D - 391 ° (c 0.2, MeOH). Both the hydrochloride, m.p. 216-9°C and the hydrobromide, m.p. 223-6°C have been described.

Chemical Properties

clear colorless to yellow liquid

Uses

analeptic

Uses

N,N-Diethylnicotinamide (DENC) is commonly used as a ligand to prepare tetranuclear copper complexes.

Definition

ChEBI: Nikethamide is a pyridinecarboxamide. It is functionally related to a nicotinamide.

Application

N,N-Diethylnicotinamide (DENA) is one of the central respiratory stimulants and is used in the study of respiratory failure. DENA is also an excellent hydrophilic agent for paclitaxel (PTX) and improves the water solubility of PTX.

General Description

Clear light yellow viscous liquid or crystalline solid. Slightly bitter taste followed by a faint sensation of the warmth.

Air & Water Reactions

Water soluble.

Reactivity Profile

N,N-DIETHYLNICOTINAMIDE is incompatible with sodium carbonate solutions which cause precipitation. .

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition N,N-DIETHYLNICOTINAMIDE emits toxic fumes.

Fire Hazard

N,N-DIETHYLNICOTINAMIDE is combustible.

Safety Profile

Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. When heated to decomposition it emits toxic fumes of NOx.

References

Yunusov, Akramov, Yunusov, Dokl. Akad. Nauk. USSR, 162,607 (1965)
Yunusov, Akramov, Yunusov, Khim. Prir. Soedin., 2, 340 (1966)
Ibragimova, Yunusov, Yunusov, ibid, 6,438 (1970)
Yunusov, et al., ibid, 7, 380 (1971)

N,N-DIETHYLNICOTINAMIDE synthesis

Synthesis of N,N-DIETHYLNICOTINAMIDE from 3-Pyridyl bromide and carbon monoxide and Diethylamine

N,N-DIETHYLNICOTINAMIDE Preparation Products And Raw materials

Raw materials

Nicotinic acid Diethylamine

Preparation Products

3-Pyridinecarboxaldehyde Pyrido[3,4-g]isoquinoline-5,10-dione

N,N-DIETHYLNICOTINAMIDE Suppliers

Global( 228)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Zhejiang Kinso Technology Co., LTD.	+8619857958369	sales@kinsopharma.com	China	54	58
Jinan Qinmu Fine Chemical Co.,Ltd.	+8618660799346	sales@qinmuchem.com	China	1009	58
Hebei Weibang Biotechnology Co., Ltd	+8615531157085	abby@weibangbio.com	China	8810	58
Hebei Mojin Biotechnology Co., Ltd	+86 13288715578 +8613288715578	sales@hbmojin.com	China	12839	58
Hangzhou ICH Biofarm Co., Ltd	+86-0571-28186870; +undefined8613073685410	sales@ichemie.com	China	998	58
Apeloa production Co.,Limited	+8619933239880	admin@apcl.com.cn	China	852	58
Henan Suikang Pharmaceutical Co.,Ltd.	+86-18239973690 +86-18239973690	sales@suikangpharm.com	China	311	58
Frapp's ChemicalNFTZ Co., Ltd.	+86 (576) 8169-6106	sales@frappschem.com	China	880	50
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	18774	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21634	55

Supplier	Advantage
Zhejiang Kinso Technology Co., LTD.	58
Jinan Qinmu Fine Chemical Co.,Ltd.	58
Hebei Weibang Biotechnology Co., Ltd	58
Hebei Mojin Biotechnology Co., Ltd	58
Hangzhou ICH Biofarm Co., Ltd	58
Apeloa production Co.,Limited	58
Henan Suikang Pharmaceutical Co.,Ltd.	58
Frapp's ChemicalNFTZ Co., Ltd.	50
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55

View Lastest Price from N,N-DIETHYLNICOTINAMIDE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-28	N,N-DIETHYLNICOTINAMIDE 59-26-7	US $0.00 / kg	25kg	99.0%	1tons	Henan Suikang Pharmaceutical Co.,Ltd.
2024-11-21	N,N-DIETHYLNICOTINAMIDE 59-26-7	US $10.00 / KG	1KG	99%	10 mt	Hebei Weibang Biotechnology Co., Ltd
2024-11-19	Nikethamide 59-26-7	US $1.00 / g	1g	0.98	1000	Apeloa production Co.,Limited

N,N-DIETHYLNICOTINAMIDE
59-26-7
US $0.00 / kg
99.0%
Henan Suikang Pharmaceutical Co.,Ltd.

N,N-DIETHYLNICOTINAMIDE
59-26-7
US $10.00 / KG
99%
Hebei Weibang Biotechnology Co., Ltd

Nikethamide
59-26-7
US $1.00 / g
0.98
Apeloa production Co.,Limited

N,N-DIETHYLNICOTINAMIDE Spectrum

N,N-DIETHYLNICOTINAMIDE(59-26-7)MS N,N-DIETHYLNICOTINAMIDE(59-26-7)¹HNMR N,N-DIETHYLNICOTINAMIDE(59-26-7)¹³CNMR N,N-DIETHYLNICOTINAMIDE(59-26-7)IR1 N,N-DIETHYLNICOTINAMIDE(59-26-7)IR2 N,N-DIETHYLNICOTINAMIDE(59-26-7)Raman

59-26-7(N,N-DIETHYLNICOTINAMIDE)Related Search:

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1-Nicotinoyl-4-phenyl-2-pyrrolidinone N-BENZYL-N-NICOTINOYLNICOTINAMIDE N,N-Diethylnicotinamide 1-oxide (2-CHLORO-3-PYRIDINYL)(4-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]PIPERAZINO)METHANONE [4-(4-CHLOROPHENYL)-4,5,6,7-TETRAHYDROTHIENO[3,2-C]PYRIDIN-5-YL](2-CHLORO-3-PYRIDYL)METHANONE

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[(2-(TRIFLUOROMETHYL)-1,6-NAPHTHYRIDIN-3-YL)CARBONYL]PYRROLIDINE 7-CHLORO-N,N-DIETHYL-2-METHYL-5-OXO-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE (2-METHYL-1,6-NAPHTHYRIDIN-3-YL)MORPHOLINOMETHANONE

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DYNACORYL EUCORAN LABOTEST-BB LT00134638 PYRIDINE-3-CARBOXYLIC ACID DIETHYLAMIDE PYRICARDYL N,N-DIETHYLNICOTINAMIDE NICKETHAMIDE NICOTINIC ACID DIETHYLAMIDE NIKETHAMIDUM NICAMIDE 3-Pyridinecarboxamide, N,N-diethyl- Anacordone Astrocar beta-Pyrimidum Camphozone Canfodiamina Carbamidal Cardamine Cardiagen Hansacor Inicardio Kardiamid Kardonyl Kordiamin Leptamin Mediamid N,N-Diethyl-3-pyridinecarboxamide N,N-Diethyl-3-pyri-dinecarboxamide n,n-diethyl-nicotinamid Niamine Nicetamide nicethamid Nicethamide nicor Ni-Cor Nicordamin Nicorine Diethylnicotinamide Dietilamide-Carbopiridina Dinacoryl Dynamicarde Ecoran Elitone Niketamid Niketamide Nikethamide-M Niketharol Nikethyl Niketilamid Nikorin Niquetamida Nisetamide Percoral Procardine Procorman Pyridine-3-carboxydiethylamide Rehormin Salvacard