BW B70C
- CAS No.
- 134470-38-5
- Chemical Name:
- BW B70C
- Synonyms
- 70c;BW B70C;N-[3-[3-(-FLUOROPHENOXY)PHENYL]-1-METHYL-2-PROPENYL]-N-HYDROXYUREA;N-[3-[3-4(-FLUOROPHENOXY)PHENYL]-1-METHYL-2-PROPENYL]-N-HYDROXYUREA;n-(3-(3-(4-fluorophenoxy)phenyl)-1-methyl-2-propenyl)-n-hydroxy-ure;Urea, N-[3-[3-(4-fluorophenoxy)phenyl]-1-methyl-2-propen-1-yl]-N-hydroxy-;(e)-n-(3-(3-(4-fluorophenoxy)phenyl)-1-(r,s)-methylprop-2-enyl)-n-hydroxyure
- CBNumber:
- CB3730205
- Molecular Formula:
- C17H17FN2O3
- Molecular Weight:
- 316.33
- MDL Number:
- MFCD00890868
- MOL File:
- 134470-38-5.mol
SAFETY
Risk and Safety Statements
| Safety Statements | 24/25 |
|---|---|
| WGK Germany | 3 |
| RTECS | YT3976666 |
BW B70C price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | B4558 | BW B70C >98% (HPLC), solid | 134470-38-5 | 10mg | $214 | 2024-03-01 | Buy |
| Cayman Chemical | 20686 | BW B70C ≥95% | 134470-38-5 | 500μg | $24 | 2021-12-16 | Buy |
| Cayman Chemical | 20686 | BW B70C ≥95% | 134470-38-5 | 1mg | $41 | 2021-12-16 | Buy |
| Cayman Chemical | 20686 | BW B70C ≥95% | 134470-38-5 | 5mg | $82 | 2021-12-16 | Buy |
| Tocris | 1304 | BW B70C ≥98%(HPLC) | 134470-38-5 | 10 | $140 | 2021-12-16 | Buy |
BW B70C Chemical Properties,Uses,Production
Uses
BW B70C is a 5-LO (5-lipoxygenase) inhibitor.
Definition
ChEBI: A hydroxamic acid that is urea in which both the hydrogens attached to one of the nitrogens are replaced by a hydroxy and a (1E)-1-[3-(4-fluorophenoxy)phenyl]but-1-en-3-yl group. A selective inhibitor of arachidonate 5-lipoxygenase, it ca be used for the treatment of asthma.
Biological Activity
A potent, selective inhibitor of 5-lipoxygenase. In vivo, has a long half-life and high oral bioavailability.
References
[1]. payne an, jackson wp, salmon ja, et al. hydroxamic acids and hydroxyureas as novel, selective 5-lipoxygenase inhibitors for possible use in asthma. agents actions suppl, 1991, 34: 189-199.
[2]. yeadon m, dougan fl, petrovic a, et al. effect of bw b70c, a novel inhibitor of arachidonic acid 5-lipoxygenase, on allergen-induced bronchoconstriction and late-phase lung eosinophil accumulation in sensitised guinea-pigs. agents actions, 1993, 38(1-2): 8-18.
[3]. bureau mf, de castro cm, cortese c, et al. 5-lipoxygenase and endotoxin-induced microvascular albumin exchanges and leucocyte recruitment in guinea-pig lungs. eur j pharmacol, 1997, 324(1): 89-98.
[4]. jatana m, giri s, ansari ma, et al. inhibition of nf-kappab activation by 5-lipoxygenase inhibitors protects brain against injury in a rat model of focal cerebral ischemia. j neuroinflammation, 2006, 3: 12.
BW B70C Preparation Products And Raw materials
Raw materials
Preparation Products
BW B70C Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52925 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15839 | 69 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4428 | 55 |
| Shanghai Han-Xiang Chemical Co., Ltd. | 15971444841 | amber@biochempartner.com | China | 3061 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44808 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8140 | 58 |
| Xianning Shen Lan Biomedical Research and Development Co., Ltd. | 18171815831 | 1341138380@qq.com | China | 3271 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 4871 | 58 |