Carbimazole
- CAS No.
- 22232-54-8
- Chemical Name:
- Carbimazole
- Synonyms
- Carbimazol;Carbinazole;Ethyl 3-methyl-2-thioxo-2,3-dihydro-1H-imidazole-1-carboxylate;CG1;NUPL2;Tyrazol;Basolest;CARBIMAZOLE;Athyromazole;Neomercazole
- CBNumber:
- CB3731303
- Molecular Formula:
- C7H10N2O2S
- Molecular Weight:
- 186.23
- MDL Number:
- MFCD00027421
- MOL File:
- 22232-54-8.mol
- MSDS File:
- SDS
| Melting point | 124°C |
|---|---|
| Boiling point | 240.4±23.0 °C(Predicted) |
| Density | 1.2900 (rough estimate) |
| refractive index | 1.5400 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO: soluble5mg/mL, clear (warmed) |
| form | powder |
| pka | -1.70±0.20(Predicted) |
| color | white to beige |
| Water Solubility | Soluble in water, ethanol, chloroform and acetone. Sightly soluble in water. |
| Sensitive | Light Sensitive |
| Merck | 14,1798 |
| BRN | 144339 |
| InChIKey | CFOYWRHIYXMDOT-UHFFFAOYSA-N |
| CAS DataBase Reference | 22232-54-8(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 8KQ660G60G |
| ATC code | H03BB01 |
| NIST Chemistry Reference | Carbimazole(22232-54-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H317-H319 | |||||||||
| Precautionary statements | P261-P280a-P301+P312a-P305+P351+P338-P321-P501a | |||||||||
| Risk Statements | 22-36-43 | |||||||||
| Safety Statements | 22-36/37/39 | |||||||||
| RIDADR | 3335 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | NJ2441000 | |||||||||
| HS Code | 2933.29.9000 | |||||||||
| NFPA 704 |
|
Carbimazole price More Price(41)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0931 | Carbimazole ≥98% (HPLC) | 22232-54-8 | 10mg | $29.4 | 2024-03-01 | Buy |
| Sigma-Aldrich | PHR1684 | Carbimazole | 22232-54-8 | 1g | $214 | 2024-03-01 | Buy |
| TCI Chemical | C1080 | Carbimazole >95.0%(HPLC) | 22232-54-8 | 5g | $65 | 2024-03-01 | Buy |
| TCI Chemical | C1080 | Carbimazole >95.0%(HPLC) | 22232-54-8 | 25g | $195 | 2024-03-01 | Buy |
| Alfa Aesar | L08218 | Ethyl 3-methyl-2-thionoimidazoline-1-carboxylate, 97% | 22232-54-8 | 25g | $206.65 | 2024-03-01 | Buy |
Carbimazole Chemical Properties,Uses,Production
Chemical Properties
White Solid
Originator
Carbimazol,Cid Co.
Uses
Ethyl 3-methyl-2-thionoimidazoline-1-carboxylate is used as thyroid inhibitor.
Uses
Thionamide antithyroid drug.
Uses
Carbimazole, a prodrug of Methimazole (M260300), is used in the treatment of hyperthyroidism.
Definition
ChEBI: A member of the class of imidazoles that is methimazole in which the nitrogen bearing a hydrogen is converted into its ethoxycarbonyl derivative. A prodrug for methimazol, carbimazole is used for the treatment of hyperthyroidism.
Manufacturing Process
0.1 mol of 1-methyl-2-mercaptoglyoxaline is dissolved in the minimum quantity of pyridine at 0°C 0.1 mol of ethyl chloroformate is added drop wise with stirring. More pyridine is added, if necessary, to keep the mixture semi-fluid. The sludge is then placed in an ice bath for 30 minutes. The crystals are filtered off and washed firstly with a little ethanol and secondly with ethanol and water. The non-basic desired ethyl 3-methyl-2-thioimidazoline-1- carboxylate is the colourless needles having a melting point of 122°-123°C.
Therapeutic Function
Thyroid inhibitor
Clinical Use
Treatment of hyperthyroidism
Synthesis
Carbimazole, the ethyl ester of 3-methyl-2-thioimidazolin-1-carboxylic acid (25.2.7), is synthesized by a simultaneous reaction of ethylenacetal of bromoacetaldehyde with methylamine and potassium isocyanate, forming 3-methyl-2-imidazolthione (25.2.6), which is further acylated at the nitrogen atom by ethyl chloroformiate, giving the desired product (25.2.7).
Veterinary Drugs and Treatments
Carbimazole (a pro-drug of methimazole) or methimazole are
considered by most clinicians to be the agents of choice when using
drugs to treat feline hyperthyroidism. Propylthiouracil has significantly higher incidences of adverse reactions when compared to
methimazole.
Methimazole and therefore, carbimazole, may be useful for the
prophylactic prevention of cisplatin-induced nephrotoxicity in dogs.
Metabolism
Carbimazole is rapidly metabolised to thiamazole, which is concentrated in the thyroid gland. Over 90% of orally administered carbimazole is excreted in the urine as thiamazole or its metabolites. The remainder appears in faeces. There is 10% enterohepatic circulation. Thiamazole is metabolised, probably by the liver, and excreted in the urine. Less than 12% of a dose of thiamazole may be excreted as unchanged drug
Carbimazole Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29880 | 58 |
| Shanghai Arbor Chemical Co., Ltd. | 021-60451682 | act@arborchemical.com | CHINA | 904 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10311 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8618959220845 | sales@amoychem.com | China | 6383 | 58 |
| Shanghai Longyu Biotechnology Co., Ltd. | +8619521488211 | info@longyupharma.com | China | 2541 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
| SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17365 | 58 |
Related articles
- Introduction of carbimazole
- Carbimazole is a member of the class of imidazoles that is methimazole in which the nitrogen bearing a hydrogen is converted i....
- Nov 24，2021
View Lastest Price from Carbimazole manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-12-13 | Carbimazole
22232-54-8
|
US $0.00-0.00 / Kg/Drum | 1KG | 99%min; BP | 500kg | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2024-11-19 | Carbimazole
22232-54-8
|
US $46.00 / mg | 99.22% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-11-19 | Carbimazole
22232-54-8
|
US $46.00 / mg | 99.22% | 10g | TargetMol Chemicals Inc. |
-
- Carbimazole
22232-54-8
- US $0.00-0.00 / Kg/Drum
- 99%min; BP
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Carbimazole
22232-54-8
- US $46.00 / mg
- 99.22%
- TargetMol Chemicals Inc.
-
- Carbimazole
22232-54-8
- US $46.00 / mg
- 99.22%
- TargetMol Chemicals Inc.
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