DELTORPHIN II
- CAS No.
- 122752-16-3
- Chemical Name:
- DELTORPHIN II
- Synonyms
- DADELT II;Declostatin;DELTORPHIN B;Deltorphin 2;DELTORPHIN II;Deltorphin 2(TFA);ala(2)-deltorphini;DELTORPHIN 2?, >98%;Y-{d-Ala}-FEVVG-NH2;[D-ALA2]-DELTORPHIN II
- CBNumber:
- CB3759219
- Molecular Formula:
- C38H54N8O10
- Molecular Weight:
- 782.88
- MDL Number:
- MFCD00080072
- MOL File:
- 122752-16-3.mol
DELTORPHIN II price More Price(19)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | T0675 | [D-Ala2]-Deltorphin II ≥97% (HPLC) | 122752-16-3 | 1mg | $137 | 2024-03-01 | Buy |
Tocris | 1180 | [D-Ala2]-Deltorphin II | 122752-16-3 | 1 | $101 | 2021-12-16 | Buy |
Usbiological | D2735-01B | Deltorphin II | 122752-16-3 | 1mg | $531 | 2021-12-16 | Buy |
TRC | D228838 | [D-Ala2]-Deltorphin II | 122752-16-3 | 10mg | $505 | 2021-12-16 | Buy |
ApexBio Technology | B5072 | [D-Ala2]-Deltorphin II | 122752-16-3 | 10mg | $520 | 2021-12-16 | Buy |
DELTORPHIN II Chemical Properties,Uses,Production
Uses
[D-Ala2]-Deltorphin II (cas# 122752-16-3) is a useful research chemical.Deltorphin II is one of the naturally occurring peptides with high affinity and selectivity for δ-??opioid binding sites. Deltorphin II showed even higher affinity for δ-??opioid receptors than previously characterized deltorphins. Also, Deltorphin II were identified as new transport substrates of OATP-??A
Definition
ChEBI: Deltorphin B is a peptide.
Biological Activity
[d-ala2]-deltorphin ii (dadelt ii) is a natural agonist of δ opioid receptor with ki or ic50 value of 0.41 nm [1, 2].opioid receptors are most abundant in the central nervous system, but are also localized in many peripheral tissues in mammalian organisms. there are three types of opioid receptors that are well-defined; the μ, δ and κ receptors [2].[d-pen2, d-pen5]enkephalin (dpdpe) is a second highly selective agonist of δ [3]. treatment with dpdpe at 1 m for as short as 3 min significantly diminished the inhibition of the opioid receptor in ng108-15 cells to cyclic amp production. that means neuronal delta opioid receptor underwent acute desensitization. this desensitization was temporally parallel to the phosphorylation of delta opioid receptor 3 min. after agonist stimulation [4].i.c.v. administration of dadelt ii from 0.38-12.78 nm resulted in a dose- and time-related antinociception. 10 min after the administration of dadelt ii, the maximal antinociceptive response was seen. until 60 min after the administration of dadelt ii, effects were detected. these antinociceptive effects of i.c.v. dadelt ii were antagonized by the selective δ antagonist, ici 174,864 [3]. after supraspinal and spinal administration in rats intracerebroventricularly, dadelt ii at 0.2, 1, 10 μg/rat in a dose-related fashion inhibited diarrhea and colonic bead expulsion but did not show any effect on the rate of small intestine transit. spinal administration of dadelt ii at the same dose produced similar results. naltrindole is a selective antagonist of the δ opioid receptor. subcutaneous pretreatment with naltrindole at 1 and 10 mg/kg antagonized effects of dadelt ii partially and completely, respectively [1].
Biochem/physiol Actions
Selective δ2 opioid receptor agonist
storage
Store at -20°C
References
[1]. broccardo m, improta g. antidiarrheal and colonic antipropulsive effects of spinal and supraspinal administration of the natural δ opioid receptor agonist,[d-ala2] deltorphin ii, in the rat. european journal of pharmacology, 1992, 218(1): 69-73.
[2]. janecka a, fichna j, janecki t. opioid receptors and their ligands. current topics in medicinal chemistry, 2004, 4(1): 1-17.
[3]. jiang q, mosberg hi, porreca f. antinociceptive effects of [d-ala2] deltorphin ii, a highly selective δ agonist in vivo. life sciences, 1990, 47(11): pl43-pl47.
[4]. cai y, zhang y, wu y, et al. δ opioid receptor in neuronal cells undergoes acute and homologous desensitization. biochemical and biophysical research communications, 1996, 219(2): 342-347.
DELTORPHIN II Preparation Products And Raw materials
Raw materials
Preparation Products
DELTORPHIN II Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hebei Yanxi Chemical Co., Ltd. | +86-17531190177; +8617531190177 | peter@yan-xi.com | China | 5873 | 58 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 16922 | 58 |
Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10312 | 58 |
Cellmano Biotech Limited | 0551-65326643 18156095617 | info@cellmano.com | China | 999 | 58 |
Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30253 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10522 | 58 |
Hangzhou Go Top Peptide Biotech | 0571-88211921 | sales1@gotopbio.com | CHINA | 2609 | 58 |
Chengdu Youngshe Chemical Co., Ltd. | +8618108235634 | Cecilia@youngshechem.com | China | 2345 | 58 |
Nanjing Doge Biomedical Technology Co., Ltd | +86-25-58227606 +86-15305155328 | sales@dogechemical.com | China | 4128 | 58 |
View Lastest Price from DELTORPHIN II manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
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2023-11-27 | DELTORPHIN II
122752-16-3
|
US $0.00 / GRAM | 1GRAM | 99% | 20 TONS | Wuhan Senwayer Century Chemical Co.,Ltd | |
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2023-10-10 | DELTORPHIN II
122752-16-3
|
US $0.00 / kg | 1kg | 0.99 | 20tons | Hebei Yanxi Chemical Co., Ltd. |
-
- DELTORPHIN II
122752-16-3
- US $0.00 / GRAM
- 99%
- Wuhan Senwayer Century Chemical Co.,Ltd
-
- DELTORPHIN II
122752-16-3
- US $0.00 / kg
- 0.99
- Hebei Yanxi Chemical Co., Ltd.