L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE
- CAS No.
- 67953-08-6
- Chemical Name:
- L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE
- Synonyms
- H-GLU(PNA)-OH HCL;GPNA (hydrochloride);gamma-L-Glutamyl-4-nitroanilideHCl;7-bromo-6-oxocholestan-3-yl acetate;gamma-L-Glutamyl-p-nitroanilide HCl;L-GAMMA-GLUTAMYL-P-NITROANILIDE HYDROCHLORIDE;L-GAMMA-GLUTAMYL 4-NITROANILIDE HYDROCHLORIDE;GAMMA-L-GLUTAMYL-P-NITROANILIDE HYDROCHLORIDE;n-(4-nitrophenyl)-l-glutaminmonohydrochloride;N-(4-nitrophenyl)-L-glutamine monohydrochloride
- CBNumber:
- CB3779866
- Molecular Formula:
- C11H14ClN3O5
- Molecular Weight:
- 303.7
- MDL Number:
- MFCD00039054
- MOL File:
- 67953-08-6.mol
- MSDS File:
- SDS
storage temp. | 2-8°C |
---|---|
solubility | Soluble in Water (up to 5 mg/ml). |
form | solid |
color | Off-white |
Stability | Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 1 month. |
FDA UNII | 7FHH4FVM3N |
EPA Substance Registry System | L-Glutamine, N-(4-nitrophenyl)-, monohydrochloride (67953-08-6) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P305+P351+P338 |
Safety Statements | 22-24/25 |
WGK Germany | 3 |
L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE price More Price(18)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | G6133 | L-Glutamic acid γ-(p-nitroanilide) hydrochloride γ-glutamyl transpeptidase substrate | 67953-08-6 | 1g | $171 | 2024-03-01 | Buy |
Sigma-Aldrich | G6133 | L-Glutamic acid γ-(p-nitroanilide) hydrochloride γ-glutamyl transpeptidase substrate | 67953-08-6 | 5g | $232.8 | 2024-03-01 | Buy |
Sigma-Aldrich | G6133 | L-Glutamic acid γ-(p-nitroanilide) hydrochloride γ-glutamyl transpeptidase substrate | 67953-08-6 | 25g | $2030 | 2024-03-01 | Buy |
TRC | G597108 | L-Glutamic acid γ-(p-nitroanilide) hydrochloride | 67953-08-6 | 100mg | $70 | 2021-12-16 | Buy |
Chem-Impex | 00412 | L-Glutamicacidγ-(p-nitroanilide)hydrochloride,99%(HPLC) 99%(HPLC) | 67953-08-6 | 1G | $89.6 | 2021-12-16 | Buy |
L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE Chemical Properties,Uses,Production
Description
L-γ-Glutamyl-p-nitroanilide (67953-08-6; GPNA) is a substrate for γ-glutamyl transpeptidase. GPNA is used for the determination of γ-glutamyl transpeptidase hydrolytic activity via spectrophotometric monitoring of p-nitroaniline released by the action of the enzyme on GPNA.1 GPNA has also been shown to be an inhibitor of glutamine uptake – solute-linked carrier family A1 member 5 (SLC1A5).2?Cellular uptake of L-glutamine (regulated by SLC1A5) is a rate-limiting step that activates mTOR and is, thus, an interesting cancer chemotherapy target.3
Uses
L-Glutamic acid gamma-(p-nitroanilide) is used in methods of treating cancers having a deregulated NRF2/KEAP1 pathway.
References
1) Meister?et al. (1981),?γ-Glutamyl transpeptidase; Methods Enzymol.,?77?237 2) Esslinger?et al. (2005),?N-gamma-aryl glutamine analogues as probes of the ASCT2 neutral amino acid transporter binding site; Bioorg. Med. Chem.,?13?1111 3) Nicklin?et al. (2012),?Bidirectional Transport of Amino Acid Regulates mTOR and Autophagy; Cell,?136?521
L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29824 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
GL Biochem(Binhai) Ltd. | +86-021-61263370 +8615301650015 | wuqiuyan@glschina.com | China | 2975 | 58 |
BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19915 | 58 |
Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
China Kouting Group Limited | +86 (21) 5811-6473 5811-6475 | sales@koutingchina.com | China | 496 | 60 |
Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4428 | 55 |
View Lastest Price from L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2020-01-13 | L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE
67953-08-6
|
US $1.00 / g | 1g | 99.0% | 100 kg | Career Henan Chemical Co |
- L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE
67953-08-6
- US $1.00 / g
- 99.0%
- Career Henan Chemical Co
67953-08-6(L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE)Related Search:
1of4