ASN007
- CAS No.
- 2055597-12-9
- Chemical Name:
- ASN007
- Synonyms
- ASN007;ERK-IN-3;ASN007 free base;ASN007(ERAS 007);ERK1/2,inhibit,ERK,Inhibitor,ERK IN 3,RAS,Extracellular signal regulated kinases,cancer,ERKIN3;N-[(1S)-2-amino-1-(3-chloro-5-fluorophenyl)ethyl]-1-[5-methyl-2-(oxan-4-ylamino)pyrimidin-4-yl]imidazole-4-carboxamide;N-[(1S)-2-amino-1-(3-chloro-5-fluorophenyl)ethyl]-1-{5-methyl-2-[(oxan-4-yl)amino]pyrimidin-4-yl}-1H-imidazole-4-carboxamide;1H-Imidazole-4-carboxamide, N-[(1S)-2-amino-1-(3-chloro-5-fluorophenyl)ethyl]-1-[5-methyl-2-[(tetrahydro-2H-pyran-4-yl)amino]-4-pyrimidinyl]-
- CBNumber:
- CB38080025
- Molecular Formula:
- C22H25ClFN7O2
- Molecular Weight:
- 473.93
- MDL Number:
- MOL File:
- 2055597-12-9.mol
ASN007 price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
ChemScene | CS-0131841 | ERK-IN-3 98.44% | 2055597-12-9 | 5mg | $150 | 2021-12-16 | Buy |
ChemScene | CS-0131841 | ERK-IN-3 98.44% | 2055597-12-9 | 10mg | $250 | 2021-12-16 | Buy |
ChemScene | CS-0131841 | ERK-IN-3 98.44% | 2055597-12-9 | 25mg | $550 | 2021-12-16 | Buy |
ChemScene | CS-0131841 | ERK-IN-3 98.44% | 2055597-12-9 | 50mg | $950 | 2021-12-16 | Buy |
ChemScene | CS-0131841 | ERK-IN-3 98.44% | 2055597-12-9 | 100mg | $1550 | 2021-12-16 | Buy |
ASN007 Chemical Properties,Uses,Production
Biological Activity
ERK-IN-3 is a potent and orally active inhibitor of ERK. ERK-IN-3 inhibits ERK1/2 with low single-digit nM IC50 values. ERK-IN-3 can be used for the research of cancers driven by RAS mutations[1]. ERK-IN-3 inhibits the phosphorylation of ERK1/2 substrates such as RSK1, FRA1, and Elk1 in various cell lines[1].ERK-IN-3 showes single-digit nanomolar antiproliferative activity that is selective for MAPK-pathway dependent cancer cell lines[1]. ERK-IN-3 (daily p.o.) inhibits tumor growth in multiple BRAF and KRAS mutant xenograft models in mice and was well tolerated at efficacious doses[1].
References
[1]. Sanjeeva PR, et, al. Abstract B150: ASN007, a novel oral ERK inhibitor, shows robust antitumor activity in RAS mutant cancer models. Molecular Cancer Therapeutics. 2018 Jan; 17(1).
ASN007 Preparation Products And Raw materials
Raw materials
Preparation Products
ASN007 Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. | 17702719238 17702719238 | sales@sun-shinechem.com | China | 950 | 64 |
ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 | sales-cpd@caerulumpharma.com | China | 3466 | 58 |
ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8018 | 62 |
Shanghai Rechem science Co., Ltd. | 21-31433387 15618786686 | sales@rechemscience.com | China | 2972 | 58 |
Kaixin Chemical (Hong Kong) Limited | 010-88886666-01 13112345678 | loyson@tcypharm.com | China | 595 | 55 |
Amatek Scientific Co. Ltd. | 0512-56316828 | info@amateksci.com | China | 28818 | 58 |
Wuhan Sun-shine Bio-technology Corporation Limited | +86-027-6552-2453 | sales@sun-shinechem.com | China | 727 | 58 |