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Butanoic acid, 2-amino-4-[[[4-(carboxymethoxy)phenyl]hydroxymethyl]hydroxyphosphinyl]-, (2S)-

Butanoic acid, 2-amino-4-[[[4-(carboxymethoxy)phenyl]hydroxymethyl]hydroxyphosphinyl]-, (2S)- structure

CAS No.: 1413405-33-0

Chemical Name:: Butanoic acid, 2-amino-4-[[[4-(carboxymethoxy)phenyl]hydroxymethyl]hydroxyphosphinyl]-, (2S)-

Synonyms: LSP4–2022;Butanoic acid, 2-amino-4-[[[4-(carboxymethoxy)phenyl]hydroxymethyl]hydroxyphosphinyl]-, (2S)-

CBNumber:: CB38240041

Molecular Formula:: C13H18NO8P

Molecular Weight:: 347.26

MDL Number:

MOL File:: 1413405-33-0.mol

Last updated:2025-04-18 09:52:11

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Butanoic acid, 2-amino-4-[[[4-(carboxymethoxy)phenyl]hydroxymethyl]hydroxyphosphinyl]-, (2S)- Properties

Boiling point	765.0±60.0 °C(Predicted)
Density	1.540±0.06 g/cm3(Predicted)
pka	2.20±0.10(Predicted)

Butanoic acid, 2-amino-4-[[[4-(carboxymethoxy)phenyl]hydroxymethyl]hydroxyphosphinyl]-, (2S)- Chemical Properties,Uses,Production

Uses

LSP4-2022 is a potent and brain-penetrant mGlu4-selective orthosteric agonist, with an EC50 of 0.11 μM. LSP4-2022 inhibits neurotransmission in cerebellar slices from wild-type but not mGlu4 receptor-knockout mice. LSP4-2022 shows pro-depressant activity[1][2].

IC 50

mGluR4: 0.11 ± 0.0 μM (EC₅₀); mGluR7: 11.6 ± 1.9 μM (EC₅₀); mGluR8: 29.2 ± 4.2 μM (EC₅₀)

References

[1] Goudet C, et al. A novel selective metabotropic glutamate receptor 4 agonist reveals new possibilities for developing subtype selective ligands with therapeutic potential. FASEB J. 2012 Apr;26(4):1682-93. DOI:10.1096/fj.11-195941
[2] Podkowa K, Rze?niczek S, Marciniak M, Acher F, Pilc A, Pa?ucha-Poniewiera A. A novel mGlu4 selective agonist LSP4-2022 increases behavioral despair in mouse models of antidepressant action. Neuropharmacology. 2015 Oct;97:338-45. DOI:10.1016/j.neuropharm.2015.05.039

Butanoic acid, 2-amino-4-[[[4-(carboxymethoxy)phenyl]hydroxymethyl]hydroxyphosphinyl]-, (2S)- Preparation Products And Raw materials

Raw materials

Preparation Products

Butanoic acid, 2-amino-4-[[[4-(carboxymethoxy)phenyl]hydroxymethyl]hydroxyphosphinyl]-, (2S)- Suppliers

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Butanoic acid, 2-amino-4-[[[4-(carboxymethoxy)phenyl]hydroxymethyl]hydroxyphosphinyl]-, (2S)- LSP4–2022 1413405-33-0 C13H18NO8P