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GGTI-286

GGTI-286 Structure
GGTI-286 structure
CAS No.
171744-11-9
Chemical Name:
GGTI-286
Synonyms
GGTI-286;GGTI-286 (GGTI286);N-4-[2(R)-AMINO-3-MERCAPTOPROPYL]AMINO-2-PHENYLBENZOYL-(L)-LEUCINE METHYL ESTER, TFA;L-Leucine, N-[[5-[[(2R)-2-amino-3-mercaptopropyl]amino][1,1'-biphenyl]-2-yl]carbonyl]-, methyl ester
CBNumber:
CB3836589
Molecular Formula:
C23H31N3O3S
Molecular Weight:
429.58
MDL Number:
MFCD09037530
MOL File:
Mol file
Last updated:2023-07-14 17:30:11
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GGTI-286 Properties

Boiling point 626.9±55.0 °C(Predicted)
Density 1.164±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
pka 9.81±0.10(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS09
Signal word  Warning
Hazard statements  H410
Precautionary statements  P273-P391-P501

GGTI-286 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 345878 GGTI-286 - CAS 171744-11-9 - Calbiochem A potent, cell-permeable, and selective inhibitor of GGTase I. 171744-11-9 250μG $209 2023-06-20 Buy
Product number Packaging Price Buy
345878 250μG $209 Buy

GGTI-286 Chemical Properties,Uses,Production

Biological Activity

GGTI-286, a potent and cell-permeable GGTase I inhibitor, is 25-fold more potent (IC50=2 μM) than the corresponding methyl ester of FTI-276 . GGTI-286 selectively inhibits geranylgeranylation of Rap1A over farnesylation of H-Ras in NIH3T3 cells (IC50s =2 and >30 μM, respectively). GGTI-286 also potently inhibits oncogenic K-Ras4B stimulation with an IC50 of 1 μM[1].

References

[1]. E C Lerner, et al. Disruption of oncogenic K-Ras4B processing and signaling by a potent geranylgeranyltransferase I inhibitor. J Biol Chem. 1995 Nov 10;270(45):26770-3. [2]. Naoyuki Nishiya, et al. A zebrafish chemical suppressor screening identifies small molecule inhibitors of the Wnt/β-catenin pathway. Chem Biol. 2014 Apr 24;21(4):530-540.

GGTI-286 Preparation Products And Raw materials

Raw materials

Preparation Products

GGTI-286 Suppliers

Global( 20)Suppliers
Supplier Tel Email Country ProdList Advantage
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 52927 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24017 58
Supplier Advantage
Aladdin Scientific 		58
TargetMol Chemicals Inc. 58
GGTI-286 N-4-[2(R)-AMINO-3-MERCAPTOPROPYL]AMINO-2-PHENYLBENZOYL-(L)-LEUCINE METHYL ESTER, TFA GGTI-286 (GGTI286) L-Leucine, N-[[5-[[(2R)-2-amino-3-mercaptopropyl]amino][1,1'-biphenyl]-2-yl]carbonyl]-, methyl ester 171744-11-9