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INDEX NAME NOT YET ASSIGNED

INDEX NAME NOT YET ASSIGNED structure

CAS No.: 2509359-75-3

Chemical Name:: INDEX NAME NOT YET ASSIGNED

Synonyms: CP5V;3-(1-{[(2S)-1-[(2S,4R)-4-hydroxy-2-({[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}carbamoyl)pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamoyl}-3,6,9,12,15-pentaoxaoctadecan-18-amido)propyl N-{2,2,2-trichloro-1-[(pyrimidin-2-yl)amino]ethyl}carbamate

CBNumber:: CB38381807

Molecular Formula:: C46H66Cl3N9O12S

Molecular Weight:: 1075.5

MDL Number:

MOL File:: 2509359-75-3.mol

Last updated:2024-10-23 13:36:13

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INDEX NAME NOT YET ASSIGNED Properties

Density	1.326±0.06 g/cm3(Predicted)
solubility	DMSO : 150 mg/mL (139.47 mM; Need ultrasonic)
pka	9.83±0.46(Predicted)
form	Solid
color	Off-white to light yellow

INDEX NAME NOT YET ASSIGNED Chemical Properties,Uses,Production

Biological Activity

CP5V is a PROTAC, which specifically degrades Cdc20 by linking Cdc20 to the VHL/VBC complex for ubiquitination followed by proteasomal degradation. CP5V induces mitotic inhibition and suppresses cancer cell proliferation[1]. CP5V comprises a Cdc20 ligand and VHL binding moiety bridged by a PEG5 linker that induces Cdc20 degradation. CP5V induces degradation of Cdc20 leading to significant inhibition of breast cancer cell proliferation and resensitization of Taxol-resistant cell lines[1].CP5V profoundly degrades Cdc20 in both MCF7 and MDA-MB-231 cells with DC50 being approximately 1.6 μM[1].

References

[1]. Chi JJ, et al. A novel strategy to block mitotic progression for targeted therapy. EBioMedicine. 2019 Oct 25. pii: S2352-3964(19)30677-2.

INDEX NAME NOT YET ASSIGNED Preparation Products And Raw materials

Raw materials

Preparation Products

INDEX NAME NOT YET ASSIGNED Suppliers

Global( 5)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.		support@targetmol.com	United States	38632	58
Jilin Province Woda Biotechnology Co., Ltd.	13504435624	1927928688@qq.com	China	1456	58
Nantong QuanYi Biotechnology Co., Ltd	0513-66337626 18051384581	sales@chemhifuture.com	China	4933	58
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	customer_service@efebio.com	China	11974	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	19707	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
Jilin Province Woda Biotechnology Co., Ltd.	58
Nantong QuanYi Biotechnology Co., Ltd	58
Shanghai Yifei Biotechnology Co. , Ltd.	58
TargetMol Chemicals Inc.	58

View Lastest Price from INDEX NAME NOT YET ASSIGNED manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-10-24	CP5V 2509359-75-3	US $393.00-1450.00 / mg			10g	TargetMol Chemicals Inc.

CP5V
2509359-75-3
US $393.00-1450.00 / mg
TargetMol Chemicals Inc.

CP5V 3-(1-{[(2S)-1-[(2S,4R)-4-hydroxy-2-({[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}carbamoyl)pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamoyl}-3,6,9,12,15-pentaoxaoctadecan-18-amido)propyl N-{2,2,2-trichloro-1-[(pyrimidin-2-yl)amino]ethyl}carbamate 2509359-75-3 C46H66Cl3N9O12S