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2-Amino-6-methylpyridine

2-Amino-6-methylpyridine Structure
2-Amino-6-methylpyridine structure
CAS No.
1824-81-3
Chemical Name:
2-Amino-6-methylpyridine
Synonyms
6-METHYLPYRIDIN-2-AMINE;2A6PC;AKOS 91157;AKOS BBS-00004344;6-AMINO-2-PICOLINE;2-AMINO-6-PICOLINE;TIMTEC-BB SBB004355;2-Picoline, 6-amino-;2-Amino-6-methylpyri;6-methyl-2-pyridinamin
CBNumber:
CB3853241
Molecular Formula:
C6H8N2
Molecular Weight:
108.14
MDL Number:
MFCD00006331
MOL File:
1824-81-3.mol
MSDS File:
SDS
Last updated:2025-03-19 22:01:29
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2-Amino-6-methylpyridine Properties

Melting point 40-44 °C(lit.)
Boiling point 208-209 °C(lit.)
Density 1.0275 (estimate)
refractive index 1.5560 (estimate)
Flash point 218 °F
storage temp. Keep in dark place,Inert atmosphere,Room temperature
form Crystalline Low Melting Solid
pka pK1: 7.41(+1) (25°C)
color Yellow
Water Solubility very faint turbidity
Sensitive Hygroscopic
BRN 107048
InChIKey QUXLCYFNVNNRBE-UHFFFAOYSA-N
CAS DataBase Reference 1824-81-3(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 35ANN6MRBM
NIST Chemistry Reference 2-Pyridinamine, 6-methyl-(1824-81-3)
EPA Substance Registry System 2-Pyridinamine, 6-methyl- (1824-81-3)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H301-H310-H315-H319-H335
Precautionary statements  P262-P280-P301+P310+P330-P302+P352+P310-P305+P351+P338
Hazard Codes  T
Risk Statements  25-36/37/38-24/25-23/24/25-24
Safety Statements  26-36/37/39-45-37/39-28A
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  US1885000
F  10-21
TSCA  Yes
HazardClass  6.1
PackingGroup  II
HS Code  29333999
NFPA 704
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2-Amino-6-methylpyridine price More Price(27)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich A75706 2-Amino-6-methylpyridine 98% 1824-81-3 500g $50 2024-03-01 Buy
Sigma-Aldrich A75706 2-Amino-6-methylpyridine 98% 1824-81-3 100g $62.9 2024-03-01 Buy
TCI Chemical A0403 2-Amino-6-methylpyridine >98.0%(GC)(T) 1824-81-3 25g $18 2024-03-01 Buy
TCI Chemical A0403 2-Amino-6-methylpyridine >98.0%(GC)(T) 1824-81-3 100g $39 2024-03-01 Buy
Alfa Aesar A10444 2-Amino-6-methylpyridine, 99% 1824-81-3 100g $34.65 2024-03-01 Buy
Product number Packaging Price Buy
A75706 500g $50 Buy
A75706 100g $62.9 Buy
A0403 25g $18 Buy
A0403 100g $39 Buy
A10444 100g $34.65 Buy

2-Amino-6-methylpyridine Chemical Properties,Uses,Production

Chemical Properties

YELLOWISH CRYSTALLINE LOW MELTING SOLID

Uses

2-Amino-6-methylpyridine is a reagent used in the identification of selective inhibitor for phosphatidylinositol 3-kinase (PI3Ka).

Uses

Intermediate.

Definition

2-amino-6-methylpyridine, a colorless organic crystalline solid, is a prominent candidate to be exploited for the manufacturing of valuable compounds with biological activity. This synthetic nucleus can be used as precursor for the construction of diversified valuable scaffolds, e.g., 5-methyl-2-phenyl-3H-imidazo[4,5-b]pyridine and 6?bromo-5-methyl-2-phenylthiazolo[4,5-b]pyridine. The nitration of this nucleus in the presence of H2SO4 can yield N-(6-methyl-5-nitropyridin-2-yl)nitramide. It is also an important precursor for the generation of N-linked aminopiperidine-based gyrase inhibitors where during the course of reactions bromination of this nucleus was performed. Importantly, the amino group can be replaced by different halogen atoms, i.e. F, Cl, Br, or even by a nitroso group. Additionally, the methyl group on an aromatic system can be modified to the routine functional groups like aldehyde and carboxylic acid, or even bromination can be performed on this particular carbon[1].

Application

2-Amino-6-methylpyridine (2A6MPy) can be used as an electron donor and reacts with the π-acceptors tetracyanoethylene (TCNE), 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) and 2,4,4,6-tetrabromo-2,5-cyclohexanediene dione (TBCHD) to form a solid charge transfer molecule in chloroform at 25 ℃. complex (CT), and the chemical formulae of the solid CT complexes were [(2A6MPy)(TCNE)2], [(2A6MPy)2(DDQ)], [(2A6MPy)4(TBCHD)], respectively[2].

Purification Methods

Crystallise it three times from acetone and dry it under vacuum at ca 45o. Alternatively, keep it in contact with NaOH pellets for 3hours, with occasional shaking, decant and fractionally distil it [Mod et al. J Phys Chem 60 1651 1956]. It also recrystallises from CH2Cl2 on addition of pet ether. [Marzilli et al. J Am Chem Soc 108 4830 1986, Beilstein 22/9 V 210.]

References

[1] Ali A, et al. 2-Amino-6-methylpyridine based co-crystal salt formation using succinic acid: Single-crystal analysis and computational exploration. Journal of Molecular Structure, 2021; 1230: 129893.
[2] SHERZOD MADRAHIMOV . Electronic, infrared, mass spectrometry and thermal studies on the reaction of 2-amino-6-methylpyridine with π-acceptors[J]. Journal of Molecular Structure, 2020. DOI:10.1016/j.molstruc.2019.127021.

2-Amino-6-methylpyridine Preparation Products And Raw materials

Raw materials

4-Chlorobenzaldehyde 2-Picoline Sodium Ferric nitrate Ammonia

Preparation Products

2-Fluoro-6-methylpyridine 2-Amino-6-nitropyridine 2-Fluoropyridine-6-carboxylic acid 2-Hydroxy-6-methyl-5-nitropyridine 2-CHLORO-5-FLUOROPYRIDINE-6-CARBOXYLIC ACID
3-BROMO-6-CHLORO-2-METHYL-5-NITROPYRIDINE 6-(ACETYLAMINO)-2-PYRIDINECARBOXYLIC ACID 2-Amino-6-methyl-5-nitropyridine 6-METHYL-PYRIDINE-2,5-DIAMINE 6-NITROPYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER
2-ISOCYANATO-6-NITROPYRIDINE 3-Amino-6-methoxypyridine-2-carboxylic acid 6-NITROPYRIDINE-2-CARBOXAMIDE 3-Amino-6-chloro-2-picoline 6-NITROPYRIDINE-2-CARBOXYLIC ACID
3-BROMO-6-HYDROXY-2-METHYLPYRIDINE 6-NITROPYRIDINE-2-CARBONYL CHLORIDE 6-AMINO-3-BROMO-2-METHYL-5-NITRO-PYRIDINE 2-FLUORO-6-METHYLPYRIDINE-3-BORONIC ACID 2-Amino-3-nitro-6-picoline
6-Methylpyridine-2-carbonitrile 3,6-DICHLORO-4-HYDROXYPYRIDINE-2-CARBOXYLIC ACID 2-Amino-5-bromo-6-methylpyridine 3-AMINO-2-METHOXY-6-PICOLINE 2-FLUORO-6-PYRIDINECARBONYL CHLORIDE
3-BROMO-6-METHOXY-2-METHYL-5-NITROPYRIDINE 6-TERT-BUTOXYCARBONYLAMINO-PYRIDINE-2-CARBOXYLIC ACID 2-AMINO-3,5-DICHLORO-6-METHYLPYRIDINE 6-METHYLPYRIDINE-2-BORONIC ACID 5-BROMO-3-NITRO-6-METHYLPYRIDIN-2(1H)-ONE

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2-Amino-6-methylpyridine Suppliers

Global( 587)Suppliers
Supplier Tel Email Country ProdList Advantage
Terma Medicare India Pvt.,Ltd
+86-53530655; +8613916485955 shivshanghai@yahoo.com India 184 58
Hebei Chuanghai Biotechnology Co., Ltd 		+8615531157085 abby@chuanghaibio.com China 8808 58
Hebei Mujin Biotechnology Co.,Ltd 		+86 13288715578 +8613288715578 sales@hbmojin.com China 12806 58
Frapp's ChemicalNFTZ Co., Ltd. 		+86 (576) 8169-6106 sales@frappschem.com China 880 50
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21628 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29858 58
Anhui Dexinjia Biopharm Co., Ltd 		+86-531-82371986 +86-15064117275 sales01@jndxj.com China 290 58
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10406 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28172 58
Supplier Advantage
Terma Medicare India Pvt.,Ltd
58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Hebei Mujin Biotechnology Co.,Ltd 		58
Frapp's ChemicalNFTZ Co., Ltd. 		50
Henan Tianfu Chemical Co.,Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Anhui Dexinjia Biopharm Co., Ltd 		58
Shenzhen Nexconn Pharmatechs Ltd 		58
Hubei Jusheng Technology Co.,Ltd. 		58

View Lastest Price from 2-Amino-6-methylpyridine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Amino-6-methylpyridine pictures 2025-04-23 2-Amino-6-methylpyridine
1824-81-3
 US $0.00 / KG 1KG 99% 10 mt Hebei Chuanghai Biotechnology Co., Ltd
2-Amino-6-methylpyridine pictures 2025-04-04 2-Amino-6-methylpyridine
1824-81-3
 US $0.00-0.00 / KG 1KG 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
2-Amino-6-methylpyridine pictures 2025-04-02 2-Amino-6-methylpyridine
1824-81-3
 US $15.00-50.00 / kg 1kg NLT98% 5 ton per month Anhui Dexinjia Biopharm Co., Ltd

2-Amino-6-methylpyridine Spectrum

2-Amino-6-methylpyridine(1824-81-3)MS2-Amino-6-methylpyridine(1824-81-3)1HNMR2-Amino-6-methylpyridine(1824-81-3)13CNMR2-Amino-6-methylpyridine(1824-81-3)IR12-Amino-6-methylpyridine(1824-81-3)IR22-Amino-6-methylpyridine(1824-81-3)IR32-Amino-6-methylpyridine(1824-81-3)IR2-Amino-6-methylpyridine(1824-81-3)Raman

1824-81-3(2-Amino-6-methylpyridine)Related Search:

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