Iodoacetic acid
- CAS No.
- 64-69-7
- Chemical Name:
- Iodoacetic acid
- Synonyms
- IA;iodoacetate;monoiodoacetate;iodoacetic;lodoacetic acid;MONOIODOACETIC ACID;SKL245;CH2ICOOH;iodo-aceticaci;IODOACETIC ACID
- CBNumber:
- CB3854071
- Molecular Formula:
- C2H3IO2
- Molecular Weight:
- 185.95
- MDL Number:
- MFCD00002685
- MOL File:
- 64-69-7.mol
- MSDS File:
- SDS
Melting point | 79 °C |
---|---|
Boiling point | 208°C |
Density | 2.2003 (estimate) |
Flash point | 208°C |
storage temp. | 2-8°C |
solubility | H2O: soluble, clear to hazy |
form | Liquid |
pka | 3.12(at 25℃) |
color | faintly yellow |
Water Solubility | 600 g/L (20 ºC) |
Sensitive | Light Sensitive |
Merck | 14,5025 |
BRN | 1739079 |
Stability | Stable. Incompatible with strong oxidizing agents, bases, strong reducing agents. Store at -20 C. |
CAS DataBase Reference | 64-69-7(CAS DataBase Reference) |
EWG's Food Scores | 1 |
FDA UNII | WF5188V710 |
NIST Chemistry Reference | Acetic acid, iodo-(64-69-7) |
EPA Substance Registry System | Iodoacetic acid (64-69-7) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() ![]() GHS05,GHS06 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Danger | |||||||||
Hazard statements | H301-H314 | |||||||||
Precautionary statements | P260-P280-P301+P310+P330-P303+P361+P353-P305+P351+P338+P310 | |||||||||
Hazard Codes | T,C | |||||||||
Risk Statements | 25-35 | |||||||||
Safety Statements | 22-36/37/39-45 | |||||||||
RIDADR | UN 2923 8/PG 1 | |||||||||
WGK Germany | 1 | |||||||||
RTECS | AI3500000 | |||||||||
F | 8-9 | |||||||||
TSCA | Yes | |||||||||
HazardClass | 8 | |||||||||
PackingGroup | II | |||||||||
HS Code | 29159080 | |||||||||
Toxicity | LD50 intravenous in dog: 45mg/kg | |||||||||
NFPA 704 |
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Iodoacetic acid price More Price(21)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | I4386 | Iodoacetic acid ≥98.0% (T) | 64-69-7 | 10g | $55.6 | 2024-03-01 | Buy |
Sigma-Aldrich | I4386 | Iodoacetic acid ≥98.0% (T) | 64-69-7 | 25g | $102 | 2024-03-01 | Buy |
Alfa Aesar | A12410 | Iodoacetic acid, 97+% | 64-69-7 | 25g | $90.9 | 2024-03-01 | Buy |
Alfa Aesar | A12410 | Iodoacetic acid, 97+% | 64-69-7 | 100g | $255 | 2024-03-01 | Buy |
Sigma-Aldrich | I4386 | Iodoacetic acid ≥98.0% (T) | 64-69-7 | 100g | $312 | 2024-03-01 | Buy |
Iodoacetic acid Chemical Properties,Uses,Production
Chemical Properties
white to light yellow crystalline powder
Uses
Used as a general reagent in acylation reactions. A byproduct formed in treated waters, and found in marine life.
Uses
Iodoacetic acid is used as a reagent for the modification of sulfhydryl groups in organic synthesis. It reacts with cysteine moiety in proteins to prevent the re-formation of disulfide bonds during protein sequencing. It is also used as a general reagent in acylation reactions as well as in glycopeptide synthesis.
Definition
ChEBI: A haloacetic acid that is acetic acid in which one of the hydrogens of the methyl group is replaced by an iodine atom.
General Description
Colorless or white crystals.
Air & Water Reactions
May be sensitive to heat, light, and air. Water soluble
Reactivity Profile
Iodoacetic acid reacts vigorously with bases and is corrosive.
Fire Hazard
Flash point data for Iodoacetic acid are not available, but Iodoacetic acid is probably non-flammable.
Biochem/physiol Actions
Iodoacetic acid (IAA) blocks the thiol group of cysteine. IAA inhibits glyceraldehyde-3-phosphate dehydrogenase (G3PDH) by interacting with sulfhydryl group of the active site cysteine. IAA inhibits the progression of solid Ehrlich carcinoma. IAA is one of the iodinated disinfection byproducts in drinking water. It is cytotoxic to mammalian cells.
Purification Methods
Crystallise it from pet ether (b 60-80o) or CHCl3/CCl4. [Beilstein 2 IV 534.]
Iodoacetic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12450 | 58 |
SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 | sales@sdzschem.com | China | 2931 | 58 |
Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4242 | 58 |
Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 | alice@crovellbio.com | China | 8822 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34571 | 58 |
Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | China | 52861 | 58 |
sgtlifesciences pvt ltd | +8617013299288 | dj@sgtlifesciences.com | China | 12382 | 58 |
Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 | 1026@dideu.com | China | 8722 | 58 |
View Lastest Price from Iodoacetic acid manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
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2023-09-01 | Iodoacetic acid
64-69-7
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd | |
![]() |
2023-09-01 | Omeprazole
64-69-7
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd | |
![]() |
2021-05-08 | Omeprazole
64-69-7
|
US $1.00 / Kg/Bag | 1KG | 99% | 10 mt | Hebei Guanlang Biotechnology Co., Ltd. |
-
- Iodoacetic acid
64-69-7
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
-
- Omeprazole
64-69-7
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
-
- Omeprazole
64-69-7
- US $1.00 / Kg/Bag
- 99%
- Hebei Guanlang Biotechnology Co., Ltd.
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