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Iodoacetic acid

Iodoacetic acid structure

CAS No.: 64-69-7

Chemical Name:: Iodoacetic acid

Synonyms: IA;iodoacetate;monoiodoacetate;iodoacetic;lodoacetic acid;MONOIODOACETIC ACID;SKL245;CH2ICOOH;iodo-aceticaci;IODOACETIC ACID

CBNumber:: CB3854071

Molecular Formula:: C2H3IO2

Molecular Weight:: 185.95

MDL Number:: MFCD00002685

MOL File:: 64-69-7.mol

MSDS File:: SDS

Last updated:2024-12-18 14:08:52

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Iodoacetic acid Properties

Melting point	79 °C
Boiling point	208°C
Density	2.2003 (estimate)
Flash point	208°C
storage temp.	2-8°C
solubility	H2O: soluble, clear to hazy
form	Liquid
pka	3.12(at 25℃)
color	faintly yellow
Water Solubility	600 g/L (20 ºC)
Sensitive	Light Sensitive
Merck	14,5025
BRN	1739079
Stability	Stable. Incompatible with strong oxidizing agents, bases, strong reducing agents. Store at -20 C.
CAS DataBase Reference	64-69-7(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	WF5188V710
NIST Chemistry Reference	Acetic acid, iodo-(64-69-7)
EPA Substance Registry System	Iodoacetic acid (64-69-7)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS06

Signal word

Danger

Hazard statements

H301-H314

Precautionary statements

P260-P280-P301+P310+P330-P303+P361+P353-P305+P351+P338+P310

Hazard Codes

T,C

Risk Statements

25-35

Safety Statements

22-36/37/39-45

RIDADR

UN 2923 8/PG 1

WGK Germany

RTECS

AI3500000

8-9

TSCA

Yes

HazardClass

PackingGroup

HS Code

29159080

Hazardous Substances Data

64-69-7(Hazardous Substances Data)

Toxicity

LD50 intravenous in dog: 45mg/kg

NFPA 704

	0
3		0

Iodoacetic acid price More Price(21)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	I4386	Iodoacetic acid ≥98.0% (T)	64-69-7	10g	$55.6	2024-03-01	Buy
Sigma-Aldrich	I4386	Iodoacetic acid ≥98.0% (T)	64-69-7	25g	$102	2024-03-01	Buy
Alfa Aesar	A12410	Iodoacetic acid, 97+%	64-69-7	25g	$90.9	2024-03-01	Buy
Alfa Aesar	A12410	Iodoacetic acid, 97+%	64-69-7	100g	$255	2024-03-01	Buy
Sigma-Aldrich	I4386	Iodoacetic acid ≥98.0% (T)	64-69-7	100g	$312	2024-03-01	Buy

Product number	Packaging	Price	Buy
I4386	10g	$55.6	Buy
I4386	25g	$102	Buy
A12410	25g	$90.9	Buy
A12410	100g	$255	Buy
I4386	100g	$312	Buy

Iodoacetic acid Chemical Properties,Uses,Production

Chemical Properties

white to light yellow crystalline powder

Uses

Used as a general reagent in acylation reactions. A byproduct formed in treated waters, and found in marine life.

Uses

Iodoacetic acid is used as a reagent for the modification of sulfhydryl groups in organic synthesis. It reacts with cysteine moiety in proteins to prevent the re-formation of disulfide bonds during protein sequencing. It is also used as a general reagent in acylation reactions as well as in glycopeptide synthesis.

Definition

ChEBI: A haloacetic acid that is acetic acid in which one of the hydrogens of the methyl group is replaced by an iodine atom.

General Description

Colorless or white crystals.

Air & Water Reactions

May be sensitive to heat, light, and air. Water soluble

Reactivity Profile

Iodoacetic acid reacts vigorously with bases and is corrosive.

Fire Hazard

Flash point data for Iodoacetic acid are not available, but Iodoacetic acid is probably non-flammable.

Biochem/physiol Actions

Iodoacetic acid (IAA) blocks the thiol group of cysteine. IAA inhibits glyceraldehyde-3-phosphate dehydrogenase (G3PDH) by interacting with sulfhydryl group of the active site cysteine. IAA inhibits the progression of solid Ehrlich carcinoma. IAA is one of the iodinated disinfection byproducts in drinking water. It is cytotoxic to mammalian cells.

Purification Methods

Crystallise it from pet ether (b 60-80o) or CHCl3/CCl4. [Beilstein 2 IV 534.]

Iodoacetic acid Preparation Products And Raw materials

Raw materials

Chloroacetic acid Copper (II) acetate monohydrate Iodine Acetic acid

Preparation Products

Lornoxicam IODOACETYL CHLORIDE IODOACETIC ANHYDRIDE N-(2-Hydroxyethyl)glycine Acetic acid, 2-[(methylsulfonyl)oxy]-

Glycine, N-propyl-

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Iodoacetic acid Suppliers

Global( 170)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Weibang Biotechnology Co., Ltd	+8615531157085	abby@weibangbio.com	China	8806	58
Hebei Mujin Biotechnology Co.,Ltd	+86 13288715578 +8613288715578	sales@hbmojin.com	China	12832	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	+86 18953170293	sales@sdzschem.com	China	2930	58
Changzhou Ansciep Chemical Co., Ltd.	+86 519 86305871	sales@ansciepchem.com	CHINA	4241	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49374	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	info@dycnchem.com	China	52849	58
sgtlifesciences pvt ltd	+8617013299288	dj@sgtlifesciences.com	China	12373	58
Shaanxi Didu New Materials Co. Ltd	+86-89586680 +86-13289823923	1026@dideu.com	China	8670	58

Supplier	Advantage
Hebei Weibang Biotechnology Co., Ltd	58
Hebei Mujin Biotechnology Co.,Ltd	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	58
Changzhou Ansciep Chemical Co., Ltd.	58
Hubei xin bonus chemical co. LTD	58
CONIER CHEM AND PHARMA LIMITED	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
sgtlifesciences pvt ltd	58
Shaanxi Didu New Materials Co. Ltd	58

View Lastest Price from Iodoacetic acid manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-18	Iodoacetic acid 64-69-7	US $1.00 / kg	1kg	99%	10 mt	Hebei Weibang Biotechnology Co., Ltd
2024-10-29	Iodoacetic acid 64-69-7	US $0.00 / kg	20kg	99%	20 tons	Qingdao RENAS Polymer Material Co., Ltd.
2023-09-01	Iodoacetic acid 64-69-7	US $0.00 / KG	1KG	99%	50000KG/month	Hebei Mojin Biotechnology Co., Ltd

Iodoacetic acid
64-69-7
US $1.00 / kg
99%
Hebei Weibang Biotechnology Co., Ltd

Iodoacetic acid
64-69-7
US $0.00 / kg
99%
Qingdao RENAS Polymer Material Co., Ltd.

Iodoacetic acid
64-69-7
US $0.00 / KG
99%
Hebei Mojin Biotechnology Co., Ltd

Iodoacetic acid Spectrum

Iodoacetic acid(64-69-7)MS Iodoacetic acid(64-69-7)¹HNMR Iodoacetic acid(64-69-7)¹³CNMR Iodoacetic acid(64-69-7)IR1 Iodoacetic acid(64-69-7)IR2

64-69-7(Iodoacetic acid)Related Search:

Hyaluronic acid Folic acid Citric acid Ethyl 2-(Chlorosulfonyl)acetate Stearic acid

IODOACETIC ACID SODIUM SALT,IODOACETIC ACID SODIUM APPROX. 99% 2-iodopropionic acid IODOACETIC ACID ETHYL ESTER,Iodoacetic acid ethyl,2-Iodoacetic acid ethyl ester Ethyl iododifluoroacetate Iodoacetic acid 4-nitrophenyl ester

TRIIODOACETIC ACID Bis(iodoacetic acid)anhydride,Iodoacetic acid anhydride diiodoacetic acid chloroiodoacetic acid Iodoacetic acid chloride

Iodine ETHYL 2-IODOPROPIONATE IODOACETIC ACID (2-13C)

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iodo-aceticaci Kyselina jodoctova kyselinajodoctova RARECHEM AL BO 0101 VITAS-BB TBB000669 Aceticacid,iodo- CH2ICOOH IODOACETIC ACID MONO IODOACETIC ACID IODOACETIC ACID FREE ACID APPROX 99%,*YE LLOW POWDER IODOACETIC ACID APPROX. 99% WHITE TO OFF IODOACETIC ACID R. G. IodoaceticAcid>99% IodoaceticAcid97% IODOACETICACID,REAGENT Iodoethanoic acid Iodoacetic acid, 97% 25GR Iodoacetic acid, >=99.5% Iodiacetic acid IODOACETIC ACID, >= 98.0 % (T) Acetic acid, 2-iodo- SKL245 Iodoacetic acid, GR 99% iodoacetic monoiodoacetate MONOIODOACETIC ACID IA iodoacetate lodoacetic acid 64-69-7 ICH2COOH ICH2CO2H C2H3IO2 Synthetic Reagents Organic Building Blocks Organic Acids Puriss p.a. General Use Building Blocks Analytical Reagents Analytical Chromatography Product Catalog C1 to C5 Carboxylic Acids Carbonyl Compounds Reagents for cysteine modification Specific Amino Acid Modification Protein Modification Analytical Reagents for General Use I-N, Puriss p.a. Puriss p.a. Chemical Synthesis Organic Acids Synthetic Reagents K00001