ChemicalBook >> CAS DataBase List >>4H-1-Benzopyran-4-one, 6-methyl-2-(4-morpholinyl)-8-[1-(phenylamino)ethyl]-

4H-1-Benzopyran-4-one, 6-methyl-2-(4-morpholinyl)-8-[1-(phenylamino)ethyl]-

4H-1-Benzopyran-4-one, 6-methyl-2-(4-morpholinyl)-8-[1-(phenylamino)ethyl]- structure

CAS No.: 901398-68-3

Chemical Name:: 4H-1-Benzopyran-4-one, 6-methyl-2-(4-morpholinyl)-8-[1-(phenylamino)ethyl]-

Synonyms: PIK-108;6-Methyl-2-morpholino-8-(1-(phenylamino)ethyl)-4H-chromen-4-one;PIK-108,p110β,PI3K,Inhibitor,p110δ,Phosphoinositide 3-kinase,inhibit;4H-1-Benzopyran-4-one, 6-methyl-2-(4-morpholinyl)-8-[1-(phenylamino)ethyl]-

CBNumber:: CB38955688

Molecular Formula:: C22H24N2O3

Molecular Weight:: 364.44

MDL Number:

MOL File:: 901398-68-3.mol

Last updated:2023-05-21 10:59:17

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4H-1-Benzopyran-4-one, 6-methyl-2-(4-morpholinyl)-8-[1-(phenylamino)ethyl]- Properties

Boiling point	545.6±50.0 °C(Predicted)
Density	1.252±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO : 50 mg/mL (137.20 mM; Need ultrasonic)
pka	4.19±0.50(Predicted)

4H-1-Benzopyran-4-one, 6-methyl-2-(4-morpholinyl)-8-[1-(phenylamino)ethyl]- Chemical Properties,Uses,Production

Biological Activity

PIK-108 is a non-ATP competitive, allosteric p110β/p110δ selective inhibitor[1]. PIK-108 (0.1-10 μM; 1 hour) blocks phosphorylation of PKB/Akt[1].

References

[1]. Zachary A Knight, et al. A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Cell. 2006 May 19;125(4):733-47. [2]. Jack S Chen, et al. Characterization of structurally distinct, isoform-selective phosphoinositide 3’-kinase inhibitors in combination with radiation in the treatment of glioblastoma. Mol Cancer Ther. 2008 Apr;7(4):841-50.

4H-1-Benzopyran-4-one, 6-methyl-2-(4-morpholinyl)-8-[1-(phenylamino)ethyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

4H-1-Benzopyran-4-one, 6-methyl-2-(4-morpholinyl)-8-[1-(phenylamino)ethyl]- Suppliers

Global( 8)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Shanghai Beckham Medical Technology Co., Ltd	021-13816613772 13816613772	huahero21@sina.com	China	408	55
ShangHai Biochempartner Co.,Ltd	17754423994 17754423994	2853530910@QQ.com	China	8014	62
Bide Pharmatech Ltd.	400-1647117 13681763483	product02@bidepharm.com	China	62163	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	21667	58
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	customer_service@efebio.com	China	11975	58
Shanghai jerryxing Biomedical Technology Co., Ltd	17721492509	643638326@qq.com	China	5347	58
RD International Technology Co., Limited	18024082417	market@ubiochem.com	China	9268	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
Shanghai Beckham Medical Technology Co., Ltd	55
ShangHai Biochempartner Co.,Ltd	62
Bide Pharmatech Ltd.	58
TargetMol Chemicals Inc.	58
Shanghai Yifei Biotechnology Co. , Ltd.	58
Shanghai jerryxing Biomedical Technology Co., Ltd	58
RD International Technology Co., Limited	58

4H-1-Benzopyran-4-one, 6-methyl-2-(4-morpholinyl)-8-[1-(phenylamino)ethyl]- PIK-108 PIK-108,p110β,PI3K,Inhibitor,p110δ,Phosphoinositide 3-kinase,inhibit 6-Methyl-2-morpholino-8-(1-(phenylamino)ethyl)-4H-chromen-4-one 901398-68-3