Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>INDEX NAME NOT YET ASSIGNED

INDEX NAME NOT YET ASSIGNED

INDEX NAME NOT YET ASSIGNED Structure
INDEX NAME NOT YET ASSIGNED structure
CAS No.
2349307-32-8
Chemical Name:
INDEX NAME NOT YET ASSIGNED
Synonyms
IC8
CBNumber:
CB39010140
Molecular Formula:
C66H136N4O4
Molecular Weight:
1049.84
MDL Number:
MOL File:
2349307-32-8.mol
Last updated:2023-04-23 13:52:06
Request For Quotation

INDEX NAME NOT YET ASSIGNED Properties

Boiling point 964.7±65.0 °C(Predicted)
Density 0.931±0.06 g/cm3(Predicted)
solubility DMF: Slightly soluble; DMSO: Slightly soluble
form A solid
pka 14.16±0.20(Predicted)

INDEX NAME NOT YET ASSIGNED Chemical Properties,Uses,Production

Description

IC8 is an ionizable cationic lipid.1,2 It has been used in combination with other lipids for the formation of lipid nanoparticles (LNPs). Immunization with severe acute respiratory coronavirus 2 (SARS-CoV-2) spike glycoprotein mRNA in IC8- and manganese-containing LNPs induces IgG responses to SARS-CoV-2 Delta and Omicron variants in mice.1 Administration of mRNA encoding B7-H3 X CD3 bispecific T cell engaging (BiTE) antibodies in IC8-containing LNPs reduces tumor growth in MV4-11 and A375 mouse xenograft models.2

References

1. Fan, N., Chen, K., Zhu, R., et al. Manganese-coordinated mRNA vaccines with enhanced mRNA expression and immunogenicity induce robust immune responses against SARS-CoV-2 variants Sci. Adv. 8(51),eabq3500(2022).
2. Huang, C., Duan, X., Wang, J., et al. Lipid nanoparticle delivery system for mRNA encoding B7H3-redirected bispecific antibody displays potent antitumor effects on malignant tumors Adv. Sci. (Weinh) Online ahead of print,e2205532(2022).

INDEX NAME NOT YET ASSIGNED Preparation Products And Raw materials

Raw materials

Preparation Products

INDEX NAME NOT YET ASSIGNED Suppliers

Global( 5)Suppliers
Supplier Tel Email Country ProdList Advantage
DC Chemicals 021-58447131 13564518121 sales@dcchemicals.com China 9412 58
Shanghai Easy CDMO Co.,Ltd 021-61734564 August@easycdmo.com China 10010 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11975 58
Jilin Chinese Academy of Sciences-yanshen Technology 18143011203 ET-market@chemextension.com China 24552 58
Supplier Advantage
DC Chemicals 58
Shanghai Easy CDMO Co.,Ltd 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
Jilin Chinese Academy of Sciences-yanshen Technology 58
IC8 2349307-32-8 C66H136N4O4