ChemicalBook >> CAS DataBase List >>2H-Indol-2-one, 1,3-dihydro-5-methoxy-3-[[3-[(1E)-2-[6-(4-methyl-1-piperazinyl)-3-pyridinyl]ethenyl]-1H-indazol-6-yl]methylene]-, (3E)-

2H-Indol-2-one, 1,3-dihydro-5-methoxy-3-[[3-[(1E)-2-[6-(4-methyl-1-piperazinyl)-3-pyridinyl]ethenyl]-1H-indazol-6-yl]methylene]-, (3E)-

2H-Indol-2-one, 1,3-dihydro-5-methoxy-3-[[3-[(1E)-2-[6-(4-methyl-1-piperazinyl)-3-pyridinyl]ethenyl]-1H-indazol-6-yl]methylene]-, (3E)- structure

CAS No.: 1169211-37-3

Chemical Name:: 2H-Indol-2-one, 1,3-dihydro-5-methoxy-3-[[3-[(1E)-2-[6-(4-methyl-1-piperazinyl)-3-pyridinyl]ethenyl]-1H-indazol-6-yl]methylene]-, (3E)-

Synonyms: 2H-Indol-2-one, 1,3-dihydro-5-methoxy-3-[[3-[(1E)-2-[6-(4-methyl-1-piperazinyl)-3-pyridinyl]ethenyl]-1H-indazol-6-yl]methylene]-, (3E)-

CBNumber:: CB39020693

Molecular Formula:: C29H28N6O2

Molecular Weight:: 492.57

MDL Number:

MOL File:: 1169211-37-3.mol

Last updated:2023-03-31 09:12:58

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2H-Indol-2-one, 1,3-dihydro-5-methoxy-3-[[3-[(1E)-2-[6-(4-methyl-1-piperazinyl)-3-pyridinyl]ethenyl]-1H-indazol-6-yl]methylene]-, (3E)- Properties

Boiling point	794.3±60.0 °C(Predicted)
Density	1.337±0.06 g/cm3(Predicted)
pka	12.17±0.20(Predicted)

2H-Indol-2-one, 1,3-dihydro-5-methoxy-3-[[3-[(1E)-2-[6-(4-methyl-1-piperazinyl)-3-pyridinyl]ethenyl]-1H-indazol-6-yl]methylene]-, (3E)- Chemical Properties,Uses,Production

Description

CFI-400437 is a potent and selective inhibitor of polo-like kinase 4 (PLK4). The family of Polo-like kinases is important in the regulation of mitotic progression; this work keys on one member, namely Polo-like kinase 4 (PLK4). PLK4 has been identified as a candidate anticancer target which prompted a search for potent and selective inhibitors of PLK4.

2H-Indol-2-one, 1,3-dihydro-5-methoxy-3-[[3-[(1E)-2-[6-(4-methyl-1-piperazinyl)-3-pyridinyl]ethenyl]-1H-indazol-6-yl]methylene]-, (3E)- Preparation Products And Raw materials

Raw materials

Preparation Products

2H-Indol-2-one, 1,3-dihydro-5-methoxy-3-[[3-[(1E)-2-[6-(4-methyl-1-piperazinyl)-3-pyridinyl]ethenyl]-1H-indazol-6-yl]methylene]-, (3E)- Suppliers

Global( 1)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	19696	58

Supplier	Advantage
TargetMol Chemicals Inc.	58

2H-Indol-2-one, 1,3-dihydro-5-methoxy-3-[[3-[(1E)-2-[6-(4-methyl-1-piperazinyl)-3-pyridinyl]ethenyl]-1H-indazol-6-yl]methylene]-, (3E)- 1169211-37-3