ChemicalBook >> CAS DataBase List >>INDEX NAME NOT YET ASSIGNED
INDEX NAME NOT YET ASSIGNED
- CAS No.
- 2378855-09-3
- Chemical Name:
- INDEX NAME NOT YET ASSIGNED
- Synonyms
- VRK-IN-1;VRK IN 1,VRKIN1
- CBNumber:
- CB39280442
- Molecular Formula:
- C18H11F4NO2
- Molecular Weight:
- 349.28
- MDL Number:
- MFCD34368509
- MOL File:
- 2378855-09-3.mol
Last updated:2024-07-02 08:55:07
INDEX NAME NOT YET ASSIGNED Chemical Properties,Uses,Production
Biological Activity
VRK-IN-1 is a potent and selective inhibitor of vaccinia-related kinases 1 (VRK1), with an IC50 of 150 nM. VRK1 is human Ser/Thr protein kinases associated with increased cell division and neurological disorders[1]. VRK-IN-1 binds to VRK1-FL by enthalpy-driven, with a Kd of 190 nM[1].VRK-IN-1 (0.4-25 μM; 24 h) slightly decreases the viability of human HeLa cells at the concentration of 3.2 μM[1].
References
[1]. Serafim RAM, et, al. Development of Pyridine-based Inhibitors for the Human Vaccinia-related Kinases 1 and 2. ACS Med Chem Lett. 2019 Aug 19;10(9):1266-1271.
INDEX NAME NOT YET ASSIGNED Preparation Products And Raw materials
Raw materials
Preparation Products
INDEX NAME NOT YET ASSIGNED Suppliers
Global( 3)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9412 | 58 |
Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; | psaitong@jm-bio.com | China | 29778 | 58 |
TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 23963 | 58 |
Supplier | Advantage |
---|---|
DC Chemicals | 58 |
Beijing Jin Ming Biotechnology Co., Ltd. | 58 |
TargetMol Chemicals Inc. | 58 |
VRK-IN-1
VRK IN 1,VRKIN1
2378855-09-3