ChemicalBook >> CAS DataBase List >>INDEX NAME NOT YET ASSIGNED

INDEX NAME NOT YET ASSIGNED

INDEX NAME NOT YET ASSIGNED structure

CAS No.: 2378855-09-3

Chemical Name:: INDEX NAME NOT YET ASSIGNED

Synonyms: VRK-IN-1;VRK IN 1,VRKIN1

CBNumber:: CB39280442

Molecular Formula:: C18H11F4NO2

Molecular Weight:: 349.28

MDL Number:: MFCD34368509

MOL File:: 2378855-09-3.mol

Last updated:2024-07-02 08:55:07

Request For Quotation

INDEX NAME NOT YET ASSIGNED Properties

Boiling point	400.2±40.0 °C(Predicted)
Density	1.436±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO : 100 mg/mL (286.30 mM; Need ultrasonic)
pka	5.78±0.25(Predicted)
form	Solid
color	White to off-white

INDEX NAME NOT YET ASSIGNED Chemical Properties,Uses,Production

Biological Activity

VRK-IN-1 is a potent and selective inhibitor of vaccinia-related kinases 1 (VRK1), with an IC50 of 150 nM. VRK1 is human Ser/Thr protein kinases associated with increased cell division and neurological disorders[1]. VRK-IN-1 binds to VRK1-FL by enthalpy-driven, with a Kd of 190 nM[1].VRK-IN-1 (0.4-25 μM; 24 h) slightly decreases the viability of human HeLa cells at the concentration of 3.2 μM[1].

References

[1]. Serafim RAM, et, al. Development of Pyridine-based Inhibitors for the Human Vaccinia-related Kinases 1 and 2. ACS Med Chem Lett. 2019 Aug 19;10(9):1266-1271.

INDEX NAME NOT YET ASSIGNED Preparation Products And Raw materials

Raw materials

Preparation Products

INDEX NAME NOT YET ASSIGNED Suppliers

Global( 3)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
DC Chemicals	021-58447131 13564518121	sales@dcchemicals.com	China	9412	58
Beijing Jin Ming Biotechnology Co., Ltd.	010-60605840 15801484223;	psaitong@jm-bio.com	China	29778	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	23963	58

Supplier	Advantage
DC Chemicals	58
Beijing Jin Ming Biotechnology Co., Ltd.	58
TargetMol Chemicals Inc.	58

VRK-IN-1 VRK IN 1,VRKIN1 2378855-09-3