Pyridostigmine
- CAS No.
- Chemical Name:
- Pyridostigmine
- Synonyms
- Pyridostigmine
- CBNumber:
- CB41018077
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
| FDA UNII | 19QM69HH21 |
|---|---|
| ATC code | N07AA02 |
Pyridostigmine Chemical Properties,Uses,Production
Uses
Qualitatively, the pharmacological properties of pyridostigmine are analogous to neostigmine.
Clinical Use
Pyridostigmine, a closely related structure to neostigmine that incorporates the charged nitrogen into a pyridine ring, acts by the same mechanism as physostigmine, but it lacks CNS activity. It is orally effective and, compared to neostigmine, has a longer duration of action and a lower incidence of side effects. Thus, it is a better choice for oral therapy of myasthenia gravis. It is approved for U.S. military use as an adjunct for prophylaxis of soman nerve gas exposure. It is also administered parenterally to reverse the effects of nondepolarizing neuromuscular blocking agents. Its elimination half-life is 1 to 2 hours.
Synthesis
Pyridostigmine, 3-[(dimethylaminocarbonyl)oxy]-1-methyl pyridinium bromide (13.2.11), is synthesized from 3-hydroxypiridine, which is reacted with dimethylaminocarbamoyl chloride, which gives 3-(dimethylaminocarbamoyl)piridine (13.2.10). The last is reacted with methylbromide, giving pyridostigmine (13.2.11) [44].
Pyridostigmine Preparation Products And Raw materials
Raw materials
Preparation Products
Pyridostigmine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Daicel Chiral Technologies (China)CO.,LTD | 021-50460086-9 15921403865 | han_yajun@dctc.daicel.com | China | 6943 | 65 |
| Supplier | Advantage |
|---|---|
| Daicel Chiral Technologies (China)CO.,LTD | 65 |