N-Desmethyl Imatinib
- CAS No.
- 404844-02-6
- Chemical Name:
- N-Desmethyl Imatinib
- Synonyms
- N-DesmethyL;Imatinib EP Impurity C;CGP-74588;STI 509-00;Norimatinib;no mesylate;Imatinib Imp.F;N-methylimatinib;DesMethyl IMatinib;Imatinib Impurity F
- CBNumber:
- CB41176575
- Molecular Formula:
- C28H29N7O
- Molecular Weight:
- 479.58
- MDL Number:
- MFCD07369291
- MOL File:
- 404844-02-6.mol
- MSDS File:
- SDS
Melting point | 99-101°C |
---|---|
Density | 1.268±0.06 g/cm3(Predicted) |
storage temp. | -20°C Freezer |
solubility | DMF: 16 mg/ml; DMF:PBS (pH 7.2) (1:4): 0.20 mg/ml; DMSO: 14 mg/ml; Ethanol: 0.20 mg/ml |
form | A lyophilized solid |
pka | 13.28±0.70(Predicted) |
color | Light yellow to yellow |
FDA UNII | 6GOH0N63QD |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() ![]() GHS07,GHS08 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Danger | |||||||||
Hazard statements | H302-H341-H351-H360-H362 | |||||||||
Precautionary statements | P201-P202-P260-P263-P264-P270-P280-P301+P312-P330-P308+P313-P405-P501 | |||||||||
Safety Statements | 24/25 | |||||||||
HS Code | 29339900 | |||||||||
NFPA 704 |
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N-Desmethyl Imatinib price More Price(16)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 16947 | N-Desmethyl Imatinib ≥95% | 404844-02-6 | 500μg | $38 | 2024-03-01 | Buy |
Cayman Chemical | 16947 | N-Desmethyl Imatinib ≥95% | 404844-02-6 | 1mg | $71 | 2024-03-01 | Buy |
Cayman Chemical | 16947 | N-Desmethyl Imatinib ≥95% | 404844-02-6 | 5mg | $275 | 2024-03-01 | Buy |
Cayman Chemical | 16947 | N-Desmethyl Imatinib ≥95% | 404844-02-6 | 10mg | $510 | 2024-03-01 | Buy |
TRC | D292045 | N-DesmethylImatinib | 404844-02-6 | 10mg | $490 | 2021-12-16 | Buy |
N-Desmethyl Imatinib Chemical Properties,Uses,Production
Description
N-desmethyl Imatinib is a major active metabolite of imatinib , an anticancer agent that selectively targets tyrosine kinases, including Bcr-ABL, platelet-derived growth factor receptor (PDGFR), and KIT. N-desmethyl Imatinib is formed when imatinib undergoes demethylation by the cytochrome P450 (CYP) isomer CYP3A4. N-desmethyl Imatinib has the same in vitro potency at Bcr-ABL kinase as imatinib (IC50 = 38 nM for both) but is only present in plasma at 10-15% of the levels of imatinib, indicating the majority of the anticancer activity can be attributed to the parent compound.
Chemical Properties
Off-White to Pale-Yellow Solid
Uses
anti-epileptic
Uses
aminoglycoside antibiotic similar to gentamycin, toxic to bacterial, yeast, higher plant and mammalian cells and to protozoans and helminthes
Uses
N-Desmethyl Imatinib (Imatinib EP Impurity C) is a metabolite of Gleevec, a tyrosine kinase inhibitor which is highly specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL). It is a COVID19-related research product.
Definition
ChEBI: N-Demethylated piperazine is a member of benzamides.
N-Desmethyl Imatinib Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21668 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9332 | 55 |
Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ | sales03@shyrchem.com | CHINA | 738 | 60 |
Lianyungang happen teng technology co., LTD | 15950718863 | wang666xt@163.com | CHINA | 295 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29894 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14336 | 58 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
View Lastest Price from N-Desmethyl Imatinib manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
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2021-07-07 | N-Desmethyl Imatinib USP/EP/BP
404844-02-6
|
US $1.10 / g | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited | |
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2019-07-06 | N-Desmethyl Imatinib
404844-02-6
|
US $1.00 / kg | 1kg | 95%-99% | 100kg | Career Henan Chemical Co |
-
- N-Desmethyl Imatinib USP/EP/BP
404844-02-6
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
-
- N-Desmethyl Imatinib
404844-02-6
- US $1.00 / kg
- 95%-99%
- Career Henan Chemical Co
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