ChemicalBook >> CAS DataBase List >>N-Desmethyl Imatinib
N-Desmethyl Imatinib
- CAS No.
- 404844-02-6
- Chemical Name:
- N-Desmethyl Imatinib
- Synonyms
- N-DesmethyL;Imatinib EP Impurity C;CGP-74588;STI 509-00;Norimatinib;no mesylate;Imatinib Imp.F;N-methylimatinib;DesMethyl IMatinib;Imatinib Impurity F
- CBNumber:
- CB41176575
- Molecular Formula:
- C28H29N7O
- Molecular Weight:
- 479.58
- MDL Number:
- MFCD07369291
- MOL File:
- 404844-02-6.mol
- MSDS File:
- SDS
Last updated:2025-01-27 09:38:02
| Melting point | 99-101°C |
|---|---|
| Density | 1.268±0.06 g/cm3(Predicted) |
| storage temp. | -20°C Freezer |
| solubility | DMF: 16 mg/ml; DMF:PBS (pH 7.2) (1:4): 0.20 mg/ml; DMSO: 14 mg/ml; Ethanol: 0.20 mg/ml |
| form | A lyophilized solid |
| pka | 13.28±0.70(Predicted) |
| color | Light yellow to yellow |
| biological source | synthetic |
| FDA UNII | 6GOH0N63QD |
| UNSPSC Code | 12352205 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H341-H351-H360-H362 | |||||||||
| Precautionary statements | P201-P202-P260-P263-P264-P270-P280-P301+P312-P330-P308+P313-P405-P501 | |||||||||
| Safety Statements | 24/25 | |||||||||
| HS Code | 29339900 | |||||||||
| NFPA 704 |
|
N-Desmethyl Imatinib price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 16947 | N-Desmethyl Imatinib ≥95% | 404844-02-6 | 500μg | $38 | 2024-03-01 | Buy |
| Cayman Chemical | 16947 | N-Desmethyl Imatinib ≥95% | 404844-02-6 | 1mg | $71 | 2024-03-01 | Buy |
| Cayman Chemical | 16947 | N-Desmethyl Imatinib ≥95% | 404844-02-6 | 5mg | $275 | 2024-03-01 | Buy |
| Cayman Chemical | 16947 | N-Desmethyl Imatinib ≥95% | 404844-02-6 | 10mg | $510 | 2024-03-01 | Buy |
| TRC | D292045 | N-DesmethylImatinib | 404844-02-6 | 10mg | $490 | 2021-12-16 | Buy |
N-Desmethyl Imatinib Chemical Properties,Uses,Production
Description
N-desmethyl Imatinib is a major active metabolite of imatinib , an anticancer agent that selectively targets tyrosine kinases, including Bcr-ABL, platelet-derived growth factor receptor (PDGFR), and KIT. N-desmethyl Imatinib is formed when imatinib undergoes demethylation by the cytochrome P450 (CYP) isomer CYP3A4. N-desmethyl Imatinib has the same in vitro potency at Bcr-ABL kinase as imatinib (IC50 = 38 nM for both) but is only present in plasma at 10-15% of the levels of imatinib, indicating the majority of the anticancer activity can be attributed to the parent compound.
Chemical Properties
Off-White to Pale-Yellow Solid
Uses
anti-epileptic
Uses
aminoglycoside antibiotic similar to gentamycin, toxic to bacterial, yeast, higher plant and mammalian cells and to protozoans and helminthes
Uses
N-Desmethyl Imatinib (Imatinib EP Impurity C) is a metabolite of Gleevec, a tyrosine kinase inhibitor which is highly specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL). It is a COVID19-related research product.
Definition
ChEBI: N-Demethylated piperazine is a member of benzamides.
N-Desmethyl Imatinib Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 212)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21632 | 55 |
| Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ | sales03@shyrchem.com | CHINA | 738 | 60 |
| Lianyungang happen teng technology co., LTD | 15950718863 | wang666xt@163.com | CHINA | 295 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29868 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
View Lastest Price from N-Desmethyl Imatinib manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-03-03 | N-Desmethyl imatinib
404844-02-6
|
US $0.00-0.00 / KG | 1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | |
 |
2024-11-19 | N-Desmethyl imatinib
404844-02-6
|
US $84.00-336.00 / mg | 98.60% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-11-19 | N-Desmethyl imatinib
404844-02-6
|
US $84.00-336.00 / mg | 98.60% | 10g | TargetMol Chemicals Inc. |
-
- N-Desmethyl imatinib
404844-02-6
- US $0.00-0.00 / KG
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
-
- N-Desmethyl imatinib
404844-02-6
- US $84.00-336.00 / mg
- 98.60%
- TargetMol Chemicals Inc.
-
- N-Desmethyl imatinib
404844-02-6
- US $84.00-336.00 / mg
- 98.60%
- TargetMol Chemicals Inc.
404844-02-6(N-Desmethyl Imatinib)Related Search:
Imatinib
1,4-Bis-[4-[4-Methyl-3-[[4-(pyridin-3-yl)pyriMidin-2-yl]aMino]phenyl]carbaMoyl]benzylpiperazine
iMatinib related substance B
2-(4-METHYLPIPERAZIN-1-YLMETHYL)BENZOIC ACID
Imatinib (Piperidine)-N-oxide
4-(4-Methylpiperazin-1-ylmethyl)benzoic acid
Guanidine, N-(2-methyl-3-nitrophenyl)-
Imatinib Impurity 7
N-DESMETHYL IMATINIB
4-Chloromethyl-N-[4-methyl-3-[[4-(pyridin-3-yl)pyrimidin-2-yl]amino]phenyl]benzamide
1of4
CGP-74588
N-[4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-4-(1-piperazinylmethyl)-benzamide
Norimatinib
STI 509-00
N-{4-Methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl}-4-(piperazin-1-ylmethyl)benzamide
DesMethyl IMatinib
DesMethyl IMatinib-d8
iMatinib related substance A
IMatinib N-DesMethyl IMpurity
Imatinib Impurity F
Imatinib metabolite N-Desmethyl Imatinib
Imatinib impurity 6/Imatinib EP Impurity C/N-Desmethyl Imatinib/N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-4-(piperazin-1-ylmethyl)benzamide
Benzamide,N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-4-(1-piperazinylmethyl)-
IMATINIB METABOLITE N-DESMETHYL IMATINIB (N-DESMETHYL IMATINIB)
Imatinib EP Impurity C (N-Desmethyl Imatinib)
Imatinib Imp.F
Imatinib Impurity 6(Imatinib EP Impurity C)
N-Desmethyl Imatinib Impurity
no mesylate
Imatinib Impurity 6（EP-C）
Imatinib Impurity C (Imatinib (Piperazine)-N1- Oxide) (crude)
Imatinib Impurity C (Imatinib (Piperidine)-N4- Oxide)
Imatinib EP Impurity C (Imatinib N-Desmethyl Impurity)
N-{4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl}-4...
Desmethyl imatinib D4Q: What is
Desmethyl imatinib D4 Q: What is the CAS Number of
Desmethyl imatinib D4 Q: What is the storage condition of
Desmethyl imatinib D4 Q: What are the applications of
Desmethyl imatinib D4
Imatinib N-Desmethyl ImpurityQ: What is
Imatinib N-Desmethyl Impurity Q: What is the CAS Number of
Imatinib N-Desmethyl Impurity Q: What is the storage condition of
Imatinib N-Desmethyl Impurity Q: What are the applications of
Imatinib N-Desmethyl Impurity
Imatinib EP Impurity C
N-DesmethyL
N-methylimatinib
Inhibitor,N Desmethyl imatinib,v-Abl,PDGFR,inhibit,NDesmethyl imatinib,Drug Metabolite,Imatinib,N-Desmethyl imatinib,c-Kit
N-Desmethyl lmatinib
N-Desmethyl imatinib, 10 mM in DMSO
404844-02-6
C28H29N7O
Metabolite Reference Standard
Isotopically Labeled Pharmaceutical Reference Standard
Intermediates & Fine Chemicals
Metabolites
Pharmaceuticals
Tyrosine Kinase Inhibitors
Various Metabolites and Impurities