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N-Desmethyl Imatinib

N-Desmethyl Imatinib Structure
N-Desmethyl Imatinib structure
CAS No.
404844-02-6
Chemical Name:
N-Desmethyl Imatinib
Synonyms
N-DesmethyL;Imatinib EP Impurity C;CGP-74588;STI 509-00;Norimatinib;no mesylate;Imatinib Imp.F;N-methylimatinib;DesMethyl IMatinib;Imatinib Impurity F
CBNumber:
CB41176575
Molecular Formula:
C28H29N7O
Molecular Weight:
479.58
MDL Number:
MFCD07369291
MOL File:
404844-02-6.mol
MSDS File:
SDS
Last updated:2024-11-19 23:02:33
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N-Desmethyl Imatinib Properties

Melting point 99-101°C
Density 1.268±0.06 g/cm3(Predicted)
storage temp. -20°C Freezer
solubility DMF: 16 mg/ml; DMF:PBS (pH 7.2) (1:4): 0.20 mg/ml; DMSO: 14 mg/ml; Ethanol: 0.20 mg/ml
form A lyophilized solid
pka 13.28±0.70(Predicted)
color Light yellow to yellow
FDA UNII 6GOH0N63QD

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS08
Signal word  Danger
Hazard statements  H302-H341-H351-H360-H362
Precautionary statements  P201-P202-P260-P263-P264-P270-P280-P301+P312-P330-P308+P313-P405-P501
Safety Statements  24/25
HS Code  29339900
NFPA 704
0
2 0

N-Desmethyl Imatinib price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 16947 N-Desmethyl Imatinib ≥95% 404844-02-6 500μg $38 2024-03-01 Buy
Cayman Chemical 16947 N-Desmethyl Imatinib ≥95% 404844-02-6 1mg $71 2024-03-01 Buy
Cayman Chemical 16947 N-Desmethyl Imatinib ≥95% 404844-02-6 5mg $275 2024-03-01 Buy
Cayman Chemical 16947 N-Desmethyl Imatinib ≥95% 404844-02-6 10mg $510 2024-03-01 Buy
TRC D292045 N-DesmethylImatinib 404844-02-6 10mg $490 2021-12-16 Buy
Product number Packaging Price Buy
16947 500μg $38 Buy
16947 1mg $71 Buy
16947 5mg $275 Buy
16947 10mg $510 Buy
D292045 10mg $490 Buy

N-Desmethyl Imatinib Chemical Properties,Uses,Production

Description

N-desmethyl Imatinib is a major active metabolite of imatinib , an anticancer agent that selectively targets tyrosine kinases, including Bcr-ABL, platelet-derived growth factor receptor (PDGFR), and KIT. N-desmethyl Imatinib is formed when imatinib undergoes demethylation by the cytochrome P450 (CYP) isomer CYP3A4. N-desmethyl Imatinib has the same in vitro potency at Bcr-ABL kinase as imatinib (IC50 = 38 nM for both) but is only present in plasma at 10-15% of the levels of imatinib, indicating the majority of the anticancer activity can be attributed to the parent compound.

Chemical Properties

Off-White to Pale-Yellow Solid

Uses

anti-epileptic

Uses

aminoglycoside antibiotic similar to gentamycin, toxic to bacterial, yeast, higher plant and mammalian cells and to protozoans and helminthes

Uses

N-Desmethyl Imatinib (Imatinib EP Impurity C) is a metabolite of Gleevec, a tyrosine kinase inhibitor which is highly specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL). It is a COVID19-related research product.

Definition

ChEBI: N-Demethylated piperazine is a member of benzamides.

N-Desmethyl Imatinib Preparation Products And Raw materials

Raw materials

Preparation Products

N-Desmethyl Imatinib Suppliers

Global( 201)Suppliers
Supplier Tel Email Country ProdList Advantage
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1803 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21634 55
Hangzhou FandaChem Co.,Ltd. 		+8615858145714 FandaChem@Gmail.com China 9116 55
Shanghai Yingrui Biopharma Co., Ltd. 		+86-21-33585366 - 03@ sales03@shyrchem.com CHINA 738 60
Lianyungang happen teng technology co., LTD 		15950718863 wang666xt@163.com CHINA 295 58
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29880 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28172 58
Hubei xin bonus chemical co. LTD 		86-13657291602 linda@hubeijusheng.com CHINA 22963 58
Standardpharm Co. Ltd. 		86-714-3992388 overseasales1@yongstandards.com United States 14332 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Supplier Advantage
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
Henan Tianfu Chemical Co.,Ltd. 		55
Hangzhou FandaChem Co.,Ltd. 		55
Shanghai Yingrui Biopharma Co., Ltd. 		60
Lianyungang happen teng technology co., LTD 		58
career henan chemical co 		58
Hubei Jusheng Technology Co.,Ltd. 		58
Hubei xin bonus chemical co. LTD 		58
Standardpharm Co. Ltd. 		58
BOC Sciences 		58

View Lastest Price from N-Desmethyl Imatinib manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
N-Desmethyl imatinib pictures 2024-11-19 N-Desmethyl imatinib
404844-02-6
 US $84.00-336.00 / mg 98.60% 10g TargetMol Chemicals Inc.
N-Desmethyl imatinib pictures 2024-11-19 N-Desmethyl imatinib
404844-02-6
 US $84.00-336.00 / mg 98.60% 10g TargetMol Chemicals Inc.
N-Desmethyl imatinib pictures 2024-11-18 N-Desmethyl imatinib
404844-02-6
 US $0.00-0.00 / KG 1KG 98.0% 10000KGS Shaanxi Dideu New Materials Co. Ltd

N-Desmethyl Imatinib Spectrum

N-Desmethyl Imatinib(404844-02-6)1HNMR

404844-02-6(N-Desmethyl Imatinib)Related Search:

Imatinib 1,4-Bis-[4-[4-Methyl-3-[[4-(pyridin-3-yl)pyriMidin-2-yl]aMino]phenyl]carbaMoyl]benzylpiperazine iMatinib related substance B 2-(4-METHYLPIPERAZIN-1-YLMETHYL)BENZOIC ACID Imatinib (Piperidine)-N-oxide
4-(4-Methylpiperazin-1-ylmethyl)benzoic acid Guanidine, N-(2-methyl-3-nitrophenyl)- Imatinib Impurity 7 N-DESMETHYL IMATINIB 4-Chloromethyl-N-[4-methyl-3-[[4-(pyridin-3-yl)pyrimidin-2-yl]amino]phenyl]benzamide
IMatinib Para-diaMinoMethylbenzene Imatinib Meta-methyl-piperazine Impurity iMatinib related substance C 3-Acetylpyridine Imatinib EP Impurity J
N-(3-GUANIDINO-4-METHYLPHENYL)-4-(METHYLPIPERAZINE-1-YL-METHYL)BENZAMIDE Imatinib EP Impurity D Imatinib (Pyridine)-N-oxide

1of4

CGP-74588 N-[4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-4-(1-piperazinylmethyl)-benzamide Norimatinib STI 509-00 N-{4-Methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl}-4-(piperazin-1-ylmethyl)benzamide DesMethyl IMatinib DesMethyl IMatinib-d8 iMatinib related substance A IMatinib N-DesMethyl IMpurity Imatinib Impurity F Imatinib metabolite N-Desmethyl Imatinib Imatinib impurity 6/Imatinib EP Impurity C/N-Desmethyl Imatinib/N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-4-(piperazin-1-ylmethyl)benzamide Benzamide,N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-4-(1-piperazinylmethyl)- IMATINIB METABOLITE N-DESMETHYL IMATINIB (N-DESMETHYL IMATINIB) Imatinib EP Impurity C (N-Desmethyl Imatinib) Imatinib Imp.F Imatinib Impurity 6(Imatinib EP Impurity C) N-Desmethyl Imatinib Impurity no mesylate Imatinib Impurity 6（EP-C） Imatinib Impurity C (Imatinib (Piperazine)-N1- Oxide) (crude) Imatinib Impurity C (Imatinib (Piperidine)-N4- Oxide) Imatinib EP Impurity C (Imatinib N-Desmethyl Impurity) N-{4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl}-4... Desmethyl imatinib D4Q: What is Desmethyl imatinib D4 Q: What is the CAS Number of Desmethyl imatinib D4 Q: What is the storage condition of Desmethyl imatinib D4 Q: What are the applications of Desmethyl imatinib D4 Imatinib N-Desmethyl ImpurityQ: What is Imatinib N-Desmethyl Impurity Q: What is the CAS Number of Imatinib N-Desmethyl Impurity Q: What is the storage condition of Imatinib N-Desmethyl Impurity Q: What are the applications of Imatinib N-Desmethyl Impurity Imatinib EP Impurity C N-DesmethyL N-methylimatinib Inhibitor,N Desmethyl imatinib,v-Abl,PDGFR,inhibit,NDesmethyl imatinib,Drug Metabolite,Imatinib,N-Desmethyl imatinib,c-Kit N-Desmethyl lmatinib 404844-02-6 C28H29N7O Metabolite Reference Standard Isotopically Labeled Pharmaceutical Reference Standard Intermediates & Fine Chemicals Metabolites Pharmaceuticals Tyrosine Kinase Inhibitors Various Metabolites and Impurities