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QN523

QN523 structure

CAS No.: 878581-60-3

Chemical Name:: QN523

Synonyms: QN523;QN523u00A0;2-Pyrazinecarboxamide, N-8-quinolinyl-;N-(Quinolin-8-yl)pyrazine-2-carboxamide

CBNumber:: CB411829878

Molecular Formula:: C14H10N4O

Molecular Weight:: 250.26

MDL Number:

MOL File:: 878581-60-3.mol

Last updated:2024-07-02 08:55:07

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QN523 Properties

Boiling point	381.8±27.0 °C(Predicted)
Density	1.374±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	DMF: 5 mg/ml,DMSO: 2 mg/ml
form	A crystalline solid
pka	10.38±0.43(Predicted)
color	Light brown to brown

QN523 Chemical Properties,Uses,Production

Biological Activity

QN523 is an anticancer agent.1 It is cytotoxic to MiaPaCa-2, PANC-1, and BxPC-3 pancreatic cancer cells (IC50s = 0.11, 0.5, and 3.3 μM, respectively). QN523 (0.5 μM) induces cell cycle arrest at the S phase in MiaPaCa-2 cells. It increases levels of the endoplasmic reticulum (ER) stress markers glucose-regulated protein 78 kDa (GRP78), DNA damage inducible transcript 3 (DDIT3), activating transcription factor 3 (ATF3), and growth differentiation factor 15 (GDF15), as well as the autophagy markers WD repeat domain phosphoinositide-interacting protein 1 (WIPI1), GABAA receptor-associated protein-like 1 (GABARAPL1), and LC3-II in MiaPaCa-2 cells in a concentration-dependent manner. QN523 reduces tumor volume in a MiaPaCa-2 mouse xenograft model.

References

1.Kuang, Y., Ye, N., Kyani, A., et al.Induction of genes implicated in stress response and autophagy by a novel quinolin-8-yl-nicotinamide QN523 in pancreatic cancerJ. Med. Chem.65(8)6133-6156(2022)

QN523 Preparation Products And Raw materials

Raw materials

Preparation Products

QN523 Suppliers

Global( 10)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9707	58
Tianjin Kailiqi Biotechnology Co., Ltd.	15076683720	klq@cw-bio.com	China	3717	55
DC Chemicals	021-58447131 13564518121	sales@dcchemicals.com	China	9412	58
Jinan Jiuli Biotechnology Co. , Ltd.	14768611851	486064515@qq.com	China	2111	58
Bide Pharmatech Ltd.	400-1647117 15221909166	product02@bidepharm.com	China	63720	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24017	58
Shaoguan Qicheng Biotechnology Co., Ltd	18122215013	780229652@qq.com	China	970	58
RD International Technology Co., Limited	18024082417	market@ubiochem.com	China	9294	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	28118	58

Supplier	Advantage
Shanghai EFE Biological Technology Co., Ltd.	58
Tianjin Kailiqi Biotechnology Co., Ltd.	55
DC Chemicals	58
Jinan Jiuli Biotechnology Co. , Ltd.	58
Bide Pharmatech Ltd.	58
TargetMol Chemicals Inc.	58
Shaoguan Qicheng Biotechnology Co., Ltd	58
RD International Technology Co., Limited	58
TargetMol Chemicals Inc.	58

QN523 2-Pyrazinecarboxamide, N-8-quinolinyl- N-(Quinolin-8-yl)pyrazine-2-carboxamide QN523u00A0 878581-60-3