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2H-Isoindole-2-acetamide, 1,3-dihydro-6-(1H-indol-5-yl)-1-oxo-α-phenyl-N-2-thiazolyl-

2H-Isoindole-2-acetamide, 1,3-dihydro-6-(1H-indol-5-yl)-1-oxo-α-phenyl-N-2-thiazolyl- structure

CAS No.: 2748162-29-8

Chemical Name:: 2H-Isoindole-2-acetamide, 1,3-dihydro-6-(1H-indol-5-yl)-1-oxo-α-phenyl-N-2-thiazolyl-

Synonyms: 2H-Isoindole-2-acetamide, 1,3-dihydro-6-(1H-indol-5-yl)-1-oxo-α-phenyl-N-2-thiazolyl-

CBNumber:: CB412229400

Molecular Formula:: C27H20N4O2S

Molecular Weight:: 464.54

MDL Number:

MOL File:: 2748162-29-8.mol

Last updated:2025-04-18 09:52:11

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2H-Isoindole-2-acetamide, 1,3-dihydro-6-(1H-indol-5-yl)-1-oxo-α-phenyl-N-2-thiazolyl- Properties

Density	1.438±0.06 g/cm3(Predicted)
pka	7.58±0.50(Predicted)

2H-Isoindole-2-acetamide, 1,3-dihydro-6-(1H-indol-5-yl)-1-oxo-α-phenyl-N-2-thiazolyl- Chemical Properties,Uses,Production

Uses

JBJ-02-112-05 is a potent, mutant-selective, allosteric and orally active EGFR inhibitor with an IC50 of 15 nM for EGFRL858R/T790M[1].

in vivo

JBJ-02-112-05 (100 mg/kg; oral gavage; once daily; for 3 days; EGFR^{L858R/T790M/C797S} genetically engineered mice) treatment inhibits phosphorylation of EGFR and downstream signaling pathways^[1].
JBJ-02-112-05 exhibits a moderate half-life of 3 hours and a _Cmax of 13.7 μM following 3 mg/kg intravenous (i.v.) dose. A 5 mg/kg oral dose of JBJ-02-112-05 achieves a half-life of 16.4 hours and a C_Cmax of 1.31 μM^[1].

Animal Model:	EGFR^{L858R/T790M/C797S} genetically engineered mice^[1]
Dosage:	100 mg/kg
Administration:	Oral gavage; once daily; for 3 days
Result:	Inhibited phosphorylation of EGFR and downstream signaling pathways.

IC 50

EGFR^L858R/T790M: 15 nM (IC₅₀)

References

[1] To C, et al. Single and Dual Targeting of Mutant EGFR with an Allosteric Inhibitor. Cancer Discov. 2019 Jul;9(7):926-943. DOI:10.1158/2159-8290.CD-18-0903

2H-Isoindole-2-acetamide, 1,3-dihydro-6-(1H-indol-5-yl)-1-oxo-α-phenyl-N-2-thiazolyl- Preparation Products And Raw materials

Raw materials

Preparation Products

2H-Isoindole-2-acetamide, 1,3-dihydro-6-(1H-indol-5-yl)-1-oxo-α-phenyl-N-2-thiazolyl- Suppliers

Global( 1)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	19699	58

Supplier	Advantage
TargetMol Chemicals Inc.	58

2H-Isoindole-2-acetamide, 1,3-dihydro-6-(1H-indol-5-yl)-1-oxo-α-phenyl-N-2-thiazolyl- 2748162-29-8