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ChemicalBook >> CAS DataBase List >>2,4-Thiazolidinedione, 3-phenyl-, 2-[2-[1-methyl-2-[[4-[2-(methylthio)-1H-benzimidazol-1-yl]-2-thiazolyl]amino]ethylidene]hydrazone]

2,4-Thiazolidinedione, 3-phenyl-, 2-[2-[1-methyl-2-[[4-[2-(methylthio)-1H-benzimidazol-1-yl]-2-thiazolyl]amino]ethylidene]hydrazone]

2,4-Thiazolidinedione, 3-phenyl-, 2-[2-[1-methyl-2-[[4-[2-(methylthio)-1H-benzimidazol-1-yl]-2-thiazolyl]amino]ethylidene]hydrazone] Structure
2,4-Thiazolidinedione, 3-phenyl-, 2-[2-[1-methyl-2-[[4-[2-(methylthio)-1H-benzimidazol-1-yl]-2-thiazolyl]amino]ethylidene]hydrazone] structure
CAS No.
2413565-19-0
Chemical Name:
2,4-Thiazolidinedione, 3-phenyl-, 2-[2-[1-methyl-2-[[4-[2-(methylthio)-1H-benzimidazol-1-yl]-2-thiazolyl]amino]ethylidene]hydrazone]
Synonyms
COX-2-IN-26;2,4-Thiazolidinedione, 3-phenyl-, 2-[2-[1-methyl-2-[[4-[2-(methylthio)-1H-benzimidazol-1-yl]-2-thiazolyl]amino]ethylidene]hydrazone]
CBNumber:
CB412592106
Molecular Formula:
C23H21N7OS3
Molecular Weight:
507.65
MDL Number:
MOL File:
2413565-19-0.mol
Last updated:2025-04-18 09:52:13
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2,4-Thiazolidinedione, 3-phenyl-, 2-[2-[1-methyl-2-[[4-[2-(methylthio)-1H-benzimidazol-1-yl]-2-thiazolyl]amino]ethylidene]hydrazone] Properties

Boiling point 719.0±70.0 °C(Predicted)
Density 1.47±0.1 g/cm3(Predicted)
pka 2.42±0.10(Predicted)

2,4-Thiazolidinedione, 3-phenyl-, 2-[2-[1-methyl-2-[[4-[2-(methylthio)-1H-benzimidazol-1-yl]-2-thiazolyl]amino]ethylidene]hydrazone] Chemical Properties,Uses,Production

Uses

COX-2-IN-26 is a potent, selective and orally active COX-2 inhibitor with IC50 values of 10.61, 0.067, 1.96 μM for COX-1, COX-2, 15-LOX, respectively. COX-2-IN-26 shows anti-inflammatory activity. COX-2-IN-26 shows gastrointestinal safety profile[1].

in vivo

COX-2-IN-26 (28 μM/kg) shows a potent anti-inflammatory activity in rats with edema inhibition relative to indomethacin of 102% and 119% in 4h and 3h, respectively[1].
. COX-2-IN-26 (10, 30, 50 mg/kg; p.o.) shows GI safety profile with normal appearance for mucosa with intact surface epithelium and preserves glands but there is some congestion of the blood vessels in albino rats[1].

IC 50

COX-2: 0.067 μM (IC50); COX-1: 10.61 μM (IC50); 15-LOX: 1.96 μM (IC50)

References

[1] Maghraby MT, et al. Novel class of benzimidazole-thiazole hybrids: The privileged scaffolds of potent anti-inflammatory activity with dual inhibition of cyclooxygenase and 15-lipoxygenase enzymes. Bioorg Med Chem. 2020 Apr 1;28(7):115403. DOI:10.1016/j.bmc.2020.115403

2,4-Thiazolidinedione, 3-phenyl-, 2-[2-[1-methyl-2-[[4-[2-(methylthio)-1H-benzimidazol-1-yl]-2-thiazolyl]amino]ethylidene]hydrazone] Preparation Products And Raw materials

Raw materials

Preparation Products

2,4-Thiazolidinedione, 3-phenyl-, 2-[2-[1-methyl-2-[[4-[2-(methylthio)-1H-benzimidazol-1-yl]-2-thiazolyl]amino]ethylidene]hydrazone] Suppliers

Global( 3)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+8613564774135 zijue.cai@tsbiochem.com United States 19893 58
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720 klq@cw-bio.com China 6344 55
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 19784 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Tianjin Kailiqi Biotechnology Co., Ltd. 55
TargetMol Chemicals Inc. 58

View Lastest Price from 2,4-Thiazolidinedione, 3-phenyl-, 2-[2-[1-methyl-2-[[4-[2-(methylthio)-1H-benzimidazol-1-yl]-2-thiazolyl]amino]ethylidene]hydrazone] manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
COX-2-IN-26 pictures 2024-10-24 COX-2-IN-26
2413565-19-0
 US $3520.00-2140.00 / mg 10g TargetMol Chemicals Inc.
  • COX-2-IN-26 pictures
  • COX-2-IN-26
    2413565-19-0
  • US $3520.00-2140.00 / mg
  • TargetMol Chemicals Inc.
2,4-Thiazolidinedione, 3-phenyl-, 2-[2-[1-methyl-2-[[4-[2-(methylthio)-1H-benzimidazol-1-yl]-2-thiazolyl]amino]ethylidene]hydrazone] COX-2-IN-26 2413565-19-0 C23H21N7OS3