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ChemicalBook >> CAS DataBase List >>Pyrazino[1',2':1,6]pyrido[3,4-b]indole-2(1H)-propanoic acid, 6-(4-bromophenyl)-3,4,6,7,12,12a-hexahydro-1,4-dioxo-, (6R,12aR)-

Pyrazino[1',2':1,6]pyrido[3,4-b]indole-2(1H)-propanoic acid, 6-(4-bromophenyl)-3,4,6,7,12,12a-hexahydro-1,4-dioxo-, (6R,12aR)-

Pyrazino[1',2':1,6]pyrido[3,4-b]indole-2(1H)-propanoic acid, 6-(4-bromophenyl)-3,4,6,7,12,12a-hexahydro-1,4-dioxo-, (6R,12aR)- Structure
Pyrazino[1',2':1,6]pyrido[3,4-b]indole-2(1H)-propanoic acid, 6-(4-bromophenyl)-3,4,6,7,12,12a-hexahydro-1,4-dioxo-, (6R,12aR)- structure
CAS No.
2414921-33-6
Chemical Name:
Pyrazino[1',2':1,6]pyrido[3,4-b]indole-2(1H)-propanoic acid, 6-(4-bromophenyl)-3,4,6,7,12,12a-hexahydro-1,4-dioxo-, (6R,12aR)-
Synonyms
PDE5-IN-5;Pyrazino[1',2':1,6]pyrido[3,4-b]indole-2(1H)-propanoic acid, 6-(4-bromophenyl)-3,4,6,7,12,12a-hexahydro-1,4-dioxo-, (6R,12aR)-
CBNumber:
CB412717817
Molecular Formula:
C23H20BrN3O4
Molecular Weight:
482.33
MDL Number:
MOL File:
2414921-33-6.mol
Last updated:2025-04-18 09:52:16
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Pyrazino[1',2':1,6]pyrido[3,4-b]indole-2(1H)-propanoic acid, 6-(4-bromophenyl)-3,4,6,7,12,12a-hexahydro-1,4-dioxo-, (6R,12aR)- Properties

Boiling point 774.1±60.0 °C(Predicted)
Density 1.68±0.1 g/cm3(Predicted)
pka 4.30±0.10(Predicted)

Pyrazino[1',2':1,6]pyrido[3,4-b]indole-2(1H)-propanoic acid, 6-(4-bromophenyl)-3,4,6,7,12,12a-hexahydro-1,4-dioxo-, (6R,12aR)- Chemical Properties,Uses,Production

Uses

PDE5-IN-5 (Compound 11) is a potent, selective phosphodiesterase 5 (PDE5) inhibitor with an IC50 of 2.0 nM[1].

IC 50

PDE5: 2.0 nM (IC50)

References

[1] ElHady AK, et al. Extending the use of tadalafil scaffold: Development of novel selective phosphodiesterase 5 inhibitors and histone deacetylase inhibitors. Bioorg Chem. 2020 May;98:103742. DOI:10.1016/j.bioorg.2020.103742

Pyrazino[1',2':1,6]pyrido[3,4-b]indole-2(1H)-propanoic acid, 6-(4-bromophenyl)-3,4,6,7,12,12a-hexahydro-1,4-dioxo-, (6R,12aR)- Preparation Products And Raw materials

Raw materials

Preparation Products

Pyrazino[1',2':1,6]pyrido[3,4-b]indole-2(1H)-propanoic acid, 6-(4-bromophenyl)-3,4,6,7,12,12a-hexahydro-1,4-dioxo-, (6R,12aR)- Suppliers

Global( 2)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+8613564774135 zijue.cai@tsbiochem.com United States 19893 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 19764 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
TargetMol Chemicals Inc. 58

View Lastest Price from Pyrazino[1',2':1,6]pyrido[3,4-b]indole-2(1H)-propanoic acid, 6-(4-bromophenyl)-3,4,6,7,12,12a-hexahydro-1,4-dioxo-, (6R,12aR)- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
PDE5-IN-5 pictures 2025-04-27 PDE5-IN-5
2414921-33-6
 US $3520.00-2140.00 / mg 10g TargetMol Chemicals Inc.
  • PDE5-IN-5 pictures
  • PDE5-IN-5
    2414921-33-6
  • US $3520.00-2140.00 / mg
  • TargetMol Chemicals Inc.
Pyrazino[1',2':1,6]pyrido[3,4-b]indole-2(1H)-propanoic acid, 6-(4-bromophenyl)-3,4,6,7,12,12a-hexahydro-1,4-dioxo-, (6R,12aR)- PDE5-IN-5 2414921-33-6