ChemicalBook >> CAS DataBase List >>Maropitant citrate hydrate
Maropitant citrate hydrate
- CAS No.
- 359875-09-5
- Chemical Name:
- Maropitant citrate hydrate
- Synonyms
- 2-HYDROXYPROPANE-1,2,3-TRICARBOXYLIC ACID;ethyl[(1R)-1-[(2R)-oxolan-2-yl]-2-phenylethyl]amine;4-(4-fluorophenyl)-1-[4-(1,2,4-triazol-1-yl)butyl]-3,6-dihydro-2H-pyridine;(7S,8S)-7-benzhydryl-N-[(2-methoxy-5-tert-butyl-phenyl)methyl]-1-azabicyclo[2.2.2]octan-8-amine;Maropitant citrate hydrate;ACIDUM CITRICUM ANHYDRICUM;(2S,3S)-N-(5-tert-butyl-2-methoxybenzyl)-2-(diphenylmethyl)-...;(2S,3S)-2-benzhydryl-N-[(5-tert-butyl-2-methoxyphenyl)methyl]-1-azabicyclo[2.2.2]octan-3-amine,2-hydroxypropane-1,2,3-tricarboxylic acid,hydrate;FEMA 2306;CT SUPPLEMENT
- CBNumber:
- CB4127749
- Molecular Formula:
- C38H48N2O8
- Molecular Weight:
- 660.81
- MDL Number:
- MFCD02098080
- MOL File:
- 359875-09-5.mol
- MSDS File:
- SDS
Last updated:2024-09-20 17:27:21
| Melting point | 153-159 °C(lit.) |
|---|---|
| Flash point | 100 °C |
| storage temp. | 2-8°C |
| solubility | H2O: 1 M at 20 °C, clear, colorless |
| form | white to off-white crystalline powder |
| Water Solubility | Water: 3 mg/mL (4.42 mM) |
| InChIKey | XDZPFSKCXRGRIO-OHTRWSNQNA-N |
| SMILES | C(O)(C(=O)O)(CC(=O)O)CC(=O)O.C(C1C=CC=CC=1)(C1C=CC=CC=1)[C@@H]1N2CCC(CC2)[C@@H]1NCC1C=C(C(C)(C)C)C=CC=1OC |&1:26,33,r| |
| CAS DataBase Reference | 359875-09-5(CAS DataBase Reference) |
| FDA UNII | LXN6S3999X |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS08,GHS09,GHS05 |
|---|---|
| Signal word | Danger |
| Hazard statements | H400-H373-H318-H410 |
| Precautionary statements | P273-P391-P501-P273-P391-P501-P260-P314-P501-P280-P305+P351+P338-P310 |
| Hazard Codes | Xi,T |
| Risk Statements | 41-42/43-36/37/38-25 |
| Safety Statements | 26-39-45-36/37-22 |
| RIDADR | UN 3284 6.1/PG 3 |
| WGK Germany | 1 |
| RTECS | GE7350000 |
| F | 9 |
Maropitant citrate hydrate price More Price(2)
Maropitant citrate hydrate Chemical Properties,Uses,Production
Description
Maropitant citrate hydrate is a specific neurokinin-1 (NK-1) receptor antagonist that selectively inhibits the production of substance P, a mediator involved in signalling vomiting. Maropitant citrate was therefore originally used to treat vomiting in dogs and cats. Currently, it is also used as an adjunct to visceral analgesia in dogs and cats, and in other species such as horses and birds.
Uses
Anti-emetic.
Pharmacokinetics
The maximum, minimum, and average concentrations of maropitant achieved at steady state were 375.5 ± 200, 16.8 ± 7.7, and 73.5 ± 45.1 ng/ml, respectively. The terminal elimination half-life was 11.6 ± 1.4 hr, and the accumulation index was 1.3 ± 0.07. Heart rate decreased between Day 1 and Day 5 (p = .005), with three horses having heart rates of 20 beats per minute and atrioventricular block on Day 5. Pharmacokinetics of repeated maropitant administration suggests the drug could be considered for use in healthy horses.
Veterinary Drugs and Treatments
Maropitant citrate injectable solution is indicated for the prevention and treatment of acute vomiting in dogs; maropitant citrate tablets are indicated for the prevention of acute vomiting and the prevention of vomiting due to motion sickness in dogs. Both are also used extra-label in cats.
Synthesis of Maropitant citrate hydrate from (2S,3S)-2-Benzhydryl-N-(5-tert-butyl-2-Methoxybenzyl)quinuclidin-3-aMine and Citric acid
Maropitant citrate hydrate Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 209)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chengdu Aslee Biopharmaceuticals, Inc. | 28-85305008 | CHINA | 964 | 58 | |
| Hpets Biotech Company (Chongqing) Co.,ltd | +8613340353813 | info@hanpets.com | China | 26 | 58 |
| Tianjin Kilo Pharmaceutical Sci-Tech Co., Ltd | +86-02223869539 +86-15560057295 | trade.kilopharma@foxmail.com | China | 27 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531153977 | allison@yan-xi.com | China | 5856 | 58 |
| HangZhou RunYan Pharma Technology Co.,LTD. | +8618882027439 | sales2@runyanpharma.com | China | 302 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20267 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| TianYuan Pharmaceutical CO.,LTD | +86-755-23284190 13684996853 | sales@tianpharm.com | CHINA | 304 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | sales@dolonchem.com | CHINA | 2972 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
View Lastest Price from Maropitant citrate hydrate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-01-21 | Maropitant Citrate
359875-09-5
|
US $0.00-0.00 / MG | 10MG | 99% HPLC | 10000 | HangZhou RunYan Pharma Technology Co.,LTD. | |
 |
2025-01-20 | Maropitant Citrate
359875-09-5
|
US $0.00 / kg | 1kg | 99% | 100kg | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2024-10-25 | Maropitant Citrate
359875-09-5
|
US $20.00-1.00 / kg | 1kg | 0.99 | 10 tons | Hebei Yanxi Chemical Co., Ltd. |
-
- Maropitant Citrate
359875-09-5
- US $0.00-0.00 / MG
- 99% HPLC
- HangZhou RunYan Pharma Technology Co.,LTD.
-
- Maropitant Citrate
359875-09-5
- US $0.00 / kg
- 99%
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Maropitant Citrate
359875-09-5
- US $20.00-1.00 / kg
- 0.99
- Hebei Yanxi Chemical Co., Ltd.
359875-09-5(Maropitant citrate hydrate)Related Search:
B-HYDROXYTRICARBALLYLIC ACID
HYDROXYTRICARBALLYLIC ACID
FEMA 2306
CEFIXIM TELLURITE SUPPLEMENT
CITRATE ION CHROMATOGRAPHY STANDARD
CT SUPPLEMENT
TELLURITE CEFIXIM SUPPLEMENT
TIMTEC-BB SBB008922
CJ 11972 hydrate
Cefixim Tellurite Supplement, Tellurite Cefixim Supplement
Maropitant citrate
Maropitant Citrate,CJ-11,972,ACIDUM CITRICUM ANHYDRICUM,B-HYDROXYTRICARBALLYLIC ACID,HYDROXYTRICARBALLYLIC ACID,FEMA 2306,CEFIXIM TELLURITE SUPPLEMENT,CITRATE ION CHROMATOGRAPHY STANDARD,CT SUP
Maropitant citrate [USAN]
Maropitant Citrate USP/EP/BP
Maropitant citrate monohydrateQ: What is
Maropitant citrate monohydrate Q: What is the CAS Number of
Maropitant citrate monohydrate
TIANFU CHEM---CT SUPPLEMENT
Maropitant citrate hydrate
2-HYDROXYPROPANE-1,2,3-TRICARBOXYLIC ACID
ACIDUM CITRICUM ANHYDRICUM
4-(4-fluorophenyl)-1-[4-(1,2,4-triazol-1-yl)butyl]-3,6-dihydro-2H-pyridine
(7S,8S)-7-benzhydryl-N-[(2-methoxy-5-tert-butyl-phenyl)methyl]-1-azabicyclo[2.2.2]octan-8-amine
ethyl[(1R)-1-[(2R)-oxolan-2-yl]-2-phenylethyl]amine
(2S,3S)-2-benzhydryl-N-[(5-tert-butyl-2-methoxyphenyl)methyl]-1-azabicyclo[2.2.2]octan-3-amine,2-hydroxypropane-1,2,3-tricarboxylic acid,hydrate
(2S,3S)-N-(5-tert-butyl-2-methoxybenzyl)-2-(diphenylmethyl)-...
Malopitan citrate
(2S,3S)-2-Benzhydryl-N-(5-(tert-butyl)-2-methoxybenzyl)quinuclidin-3-amine 2-hydroxypropane-1,2,3-tricarboxylate hydrate
(2S,3S)-2-Benzhydryl-N-(5-tert-butyl-2-methoxybenzyl)quinuclidin-3-amine citrate monohydrate
Maropitant Citrate Monohydrate
Maropitan citrate
Shuwotini DZD9008
Pafolacianine Impurity 4
359875-09-5
C32H40N2OC6H8O7H2O
C38H50N2O9
Al2H2O4
C23H29FN4O7
API
API
359875-09-5