Tauro-ω-muricholic Acid (sodium salt)
- CAS No.
- 2456348-84-6
- Chemical Name:
- Tauro-ω-muricholic Acid (sodium salt)
- Synonyms
- Ethanesulfonic acid, 2-[[(3α,5β,6α,7β)-3,6,7-trihydroxy-24-oxocholan-24-yl]amino]-, sodium salt (1:1)
- CBNumber:
- CB413503343
- Molecular Formula:
- C26H45NO7S.Na
- Molecular Weight:
- 538.69
- MDL Number:
- MOL File:
- 2456348-84-6.mol
Tauro-ω-muricholic Acid (sodium salt) Chemical Properties,Uses,Production
Uses
Tauro-ω-muricholic acid sodium (TωMCA sodium) is a bile acid released by the liver and an analog of tauro-α-muricholic acid. Tauro-ω-muricholic acid sodium is investigated as a potential marker in plasma for early-onset neonatal sepsis (EOS) and cholestasis studies[1][2]
in vivo
Sprague–Dawley rats are fed a standard diet with 1 week, and then randomly assigned to the two groups. The control group received a normal diet (10 kcal%), while the NAFLD group is fed a high-fat diet (60 kcal%; 18 weeks)[1].
10 BAs from the NAFLD group are significantly decreased in the liver, including 4 tauro-conjugated BA species including taurolithocholic acid (TLCA), THDCA, taurodeoxycholic acid (TDCA) and tauro ω-muricholic acid (TωMCA). Furthermore, βDCA, HDCA, 6-ketoLCA, 23-nordeoxycholic acid (NorDCA), LCA and 3β-chenodeoxycholic acid (βCDCA) shows lower levels in the NAFLD group[2].
References
[1] Z?hrer E, et al. Neonatal?sepsis?leads?to?early?rise?of?rare?serum?bile?acid?tauro-omega-muricholic?acid?(TOMCA).Pediatr Res.?2018 Jul;84(1):66-70. DOI:10.1038/s41390-018-0007-y
[2] Tang Y, et al. Turnover?of?bile?acids?in?liver,?serum?and?caecal?content?by?high-fat?diet?feeding?affects?hepatic?steatosis?in?rats. Biochim Biophys Acta Mol Cell Biol Lipids.?2019 Oct;1864(10):1293-1304 DOI:10.1016/j.bbalip.2019.05.016
Tauro-ω-muricholic Acid (sodium salt) Preparation Products And Raw materials
Raw materials
Preparation Products
Tauro-ω-muricholic Acid (sodium salt) Suppliers
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