guanoxabenz
- CAS No.
- 24047-25-4
- Chemical Name:
- guanoxabenz
- Synonyms
- 43-663;guanoxabenz;Hydroxyguanabenz;1-[(2,6-Dichlorobenzylidene)amino]-3-hydroxyguanidine;Hydrazinecarboximidamide, 2-[(2,6-dichlorophenyl)methylene]-N-hydroxy-
- CBNumber:
- CB41368413
- Molecular Formula:
- C8H8Cl2N4O
- Molecular Weight:
- 247.084
- MDL Number:
- MFCD00871675
- MOL File:
- 24047-25-4.mol
- MSDS File:
- SDS
| Boiling point | 383.1±52.0 °C(Predicted) |
|---|---|
| Density | 1.54±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| pka | 12.30±0.70(Predicted) |
| FDA UNII | P9HIK5V7WK |
| ATC code | C02CC07 |
guanoxabenz Chemical Properties,Uses,Production
Originator
Benezrial,Houde,France,1978
Uses
Antihypertensive.
Definition
ChEBI: Guanoxabenz is a dichlorobenzene.
Manufacturing Process
2N sodium hydroxide solution (5 ml) is added to a stirred suspension of Smethylisothiosemicarbazide hydroiodide (2.33 g) and hydroxylamine
hydrochloride (0.70 g) in water (6 ml) and stirred for 48 hours. The solution is
evaporated in vacuo to provide 1-amino-3-hydroxyguanidine. One-third of the
residue is dissolved in 16 ml of ethanol and 2,6-dichlorobenzaldehyde (0.6 g)
is added to this solution. The reaction mixture is then stirred for 48 hours.
The solution is then evaporated in vacuo and the residue dissolved in ether
(30 ml) and in hydrochloric acid (30 ml). The aqueous phase is rendered
alkaline with 2N sodium carbonate solution and extracted with ether. The
ether layer is dried with sodium sulfate and evaporated. The residue is
dissolved in ether and excess dry hydrogen chloride is passed into the
solution.
The resultant mixture is evaporated in vacuo and the residue triturated with
methylene chloride to afford a crude product. Recrystallization from ethanolether (1:3) provides 1-(2,6-dichlorobenzylideneamino)-3-hydroxyguanidine
hydrochloride; MP 173°C to 175°C. When the above process is carried out and
S-benzylisothiosemicarbazide hydroiodide is used in place of S-methylisothiosemicarbazide hydroiodide, the identical product is again
obtained.
Therapeutic Function
Antihypertensive
guanoxabenz Preparation Products And Raw materials
Raw materials
Preparation Products
guanoxabenz Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38631 | 58 | |
| TargetMol Chemicals Inc. | +8613564774135 | zijue.cai@tsbiochem.com | United States | 19885 | 58 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4861 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9729 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; | psaitong@jm-bio.com | China | 29774 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24644 | 58 |
View Lastest Price from guanoxabenz manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-10-28 | Guanoxabenz
24047-25-4
|
US $2500.00-1520.00 / mg | 10g | TargetMol Chemicals Inc. |
-
- Guanoxabenz
24047-25-4
- US $2500.00-1520.00 / mg
- TargetMol Chemicals Inc.