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LY3522348

LY3522348 Structure
LY3522348 structure
CAS No.
2568608-48-8
Chemical Name:
LY3522348
Synonyms
LY3522348;Ethanone, 2-[4-[2-[(2S)-2-methyl-1-azetidinyl]-6-(trifluoromethyl)-4-pyrimidinyl]-1H-pyrazol-1-yl]-1-(1-piperazinyl)-;(S)-2-(4-(2-(2-Methylazetidin-1-yl)-6-(trifluoromethyl)pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(piperazin-1-yl)ethan-1-one
CBNumber:
CB413811642
Molecular Formula:
C18H22F3N7O
Molecular Weight:
409.41
MDL Number:
MOL File:
2568608-48-8.mol
Last updated:2025-04-17 18:22:24
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LY3522348 Properties

Boiling point 617.799±65.00 °C(Press: 760.00 Torr)(predicted)
Density 1.517±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka 8.368±0.10(predicted)
form Solid
color Off-white to yellow

LY3522348 Chemical Properties,Uses,Production

Uses

KHK-IN-3 (Example 1) is a ketohexokinase (KHK) inhibitor. KHK-IN-3 can be used in the study of kidney disease, nonalcoholic steatohepatitis (NASH), diabetes and heart failure. KHK is a rate-limiting enzyme and fructokinase involved in fructose metabolism. KHK catalyzes the phosphorylation of fructose to fructose-1-phosphate (FIP) at the expense of ATP. The lack of feedback inhibition of fructose metabolism triggers the accumulation of downstream intermediates such as lipogenesis, gluconeogenesis, and oxidative phosphorylation[1].

References

[1] Coates David Andrew, et al. Preparation of the disubstituted pyrazole compound and their medical applications. United States, US20200392118 A1. 2020-12-17.

LY3522348 Preparation Products And Raw materials

Raw materials

Preparation Products

LY3522348 Suppliers

Global( 6)Suppliers
Supplier Tel Email Country ProdList Advantage
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. 17702719238 17702719238 sales@sun-shinechem.com China 1015 64
DC Chemicals 021-58447131 13564518121 sales@dcchemicals.com China 9409 58
ShangHai ChuanQian Chemcial Technique Centre 15869524721 3525679403@qq.com China 4348 58
Bide Pharmatech Ltd. 400-1647117 13681763483 product02@bidepharm.com China 62072 58
Shanghai Tachizaki Biomedical Research Center 18014399201 sales@chemlab-tachizaki.com China 2672 58
nanjing 13376082704 13376082704 3930959291@qq.com China 2904 58
Supplier Advantage
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. 64
DC Chemicals 58
ShangHai ChuanQian Chemcial Technique Centre 58
Bide Pharmatech Ltd. 58
Shanghai Tachizaki Biomedical Research Center 58
nanjing 58
LY3522348 (S)-2-(4-(2-(2-Methylazetidin-1-yl)-6-(trifluoromethyl)pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(piperazin-1-yl)ethan-1-one Ethanone, 2-[4-[2-[(2S)-2-methyl-1-azetidinyl]-6-(trifluoromethyl)-4-pyrimidinyl]-1H-pyrazol-1-yl]-1-(1-piperazinyl)- 2568608-48-8