β-Carotene
- CAS No.
- 7235-40-7
- Chemical Name:
- β-Carotene
- Synonyms
- β-carotene;Carotene;B-CAROTENE;Daucene;Karotin;PROVITAMIN A;β-Carotene Beadlet;C40H56;SOLATENE;Betacarotin
- CBNumber:
- CB4148267
- Molecular Formula:
- C40H56
- Molecular Weight:
- 536.89
- MDL Number:
- MFCD00001556
- MOL File:
- 7235-40-7.mol
- MSDS File:
- SDS
| Melting point | 178-179 °C |
|---|---|
| Boiling point | 644.94°C (rough estimate) |
| Density | 1.000 |
| vapor pressure | 0.004Pa at 25℃ |
| refractive index | 1.5630 (estimate) |
| Flash point | 103 °C |
| storage temp. | -20°C |
| solubility | hexane: 100 μg/mL, soluble |
| form | powder |
| color | red to purple |
| Water Solubility | Soluble in hexane, dimethyl sulfoxide, benzene, chloroform, cyclohexane. Insoluble in water. |
| Sensitive | Air & Light Sensitive |
| Merck | 14,1853 |
| BRN | 1917416 |
| Stability | Stable, but sensitive to air, heat and light. Store at -20C under nitrogen. Pyrophoric - may ignite spontaneously in air at room temperature. |
| InChIKey | OENHQHLEOONYIE-JLTXGRSLSA-N |
| LogP | 6.5 at 40℃ and pH6.5 |
| FDA 21 CFR | 184.1245; 582.5245; 73.1095; 73.2095; 73.95 |
| Substances Added to Food (formerly EAFUS) | BETA-CAROTENE |
| SCOGS (Select Committee on GRAS Substances) | Carotene (beta-carotene) |
| CAS DataBase Reference | 7235-40-7(CAS DataBase Reference) |
| NCI Dictionary of Cancer Terms | beta carotene |
| FDA UNII | 01YAE03M7J |
| NCI Drug Dictionary | beta carotene |
| ATC code | A11CA02,D02BB01 |
| NIST Chemistry Reference | «beta» Carotene(7235-40-7) |
| EPA Substance Registry System | .beta.,.beta.-Carotene (7235-40-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319-H315-H252 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P235+P410-P280-P407-P413-P420-P264-P280-P305+P351+P338-P337+P313P | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 44-36/37/38-20/21/22 | |||||||||
| Safety Statements | 7-15-18-36-26-24/25 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | FI0329500 | |||||||||
| F | 1-8-10-16 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 32030019 | |||||||||
| NFPA 704 |
|
β-Carotene price More Price(56)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 217538 | β-Carotene - CAS 7235-40-7 - Calbiochem VitaminAprecursor. | 7235-40-7 | 1g | $81.5 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1065480 | Beta Carotene United States Pharmacopeia (USP) Reference Standard | 7235-40-7 | 7x100mg | $436 | 2024-03-01 | Buy |
| TCI Chemical | C0560 | Beta Carotene >97.0%(E) | 7235-40-7 | 1g | $32 | 2024-03-01 | Buy |
| TCI Chemical | C0560 | Beta Carotene >97.0%(E) | 7235-40-7 | 5g | $94 | 2024-03-01 | Buy |
| Alfa Aesar | H60106 | Beta Carotene | 7235-40-7 | 1g | $30.7 | 2024-03-01 | Buy |
β-Carotene Chemical Properties,Uses,Production
Description
beta-Carotene is widely distributed in both plant and animal kingdoms and is the most important pro-vitamin A. In plants, it is almost always found with chlorophyll.
Chemical Properties
Yellow to orange solid.beta-Carotene is insoluble in water, but is available in water-dispersible, oil-dispersible and oil-soluble forms. It has the activity of vitamin A.
Physical properties
β-Carotene is a tetraterpene with 11 conjugated double bonds that give the molecule an orange color. It is a carotenoid compound that is present in large quantities in the human diet and subsequently is found in all human tissues, including blood. High temperature encourages the isomerization of the double bonds, which lightens the color. Absorption (blue) and fluorescence emission (red) spectra at four excitation wavelengths from β-carotene in hexane solvent at 23 °C are shown below.
Originator
Carotaben,Hermal,W. Germany,1975
Occurrence
Beta-carotene is available naturally in fruits and vegetables. Synthetically, it may be manufactured from fungi or algae.
Uses
Beta-carotene is a known antioxidant, and antioxidants are substances that may protect your cells from free radicals, which may play a role in heart disease, cancer and other diseases. beta-carotene is a coloring agent used in margarine, cheese and pudding to produce the desired color, and is also used as an additive to yellow-orange color. beta-carotene is also a precursor to carotenoids and vitamin A It is beneficial in protecting the skin from dryness and peeling. It also slows cognitive decline and is beneficial to human health.
Definition
ChEBI: A cyclic carotene obtained by dimerisation of all-trans-retinol. A strongly-coloured red-orange pigment abundant in plants and fruit and the most active and important provitamin A carotenoid.
Manufacturing Process
3.6 g (0.023 mol) of 3,8-dimethyl-3,5,7-decatrien-1,9-diyne were dissolved in
50 ml of absolute ether, and to the solution was added 0.05 mol of ethereal
phenyl-lithium solution. The mixture was refluxed for 30 minutes. Then a
solution of 11 g (0.05 mol) of 4-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2-methyl-
2-buten-1-al in 100 ml of ether was added dropwise, and the reaction mixture
was boiled for 2 hours. The reaction mixture was then hydrolyzed with
aqueous ammonium acetate solution, and the ethereal layer was separated,
dried and concentrated. The residue, i.e., 1,18-di(2,6,6-trimethyl-1-
cyclohexen-1-yl)-3,7,12,16-tetramethyl-4,15-dihydroxy-2,7,9,11,16-
octadecapentaen-5,13-diyne, was a resinous product (having 1.9 active
hydrogen atoms and absorption maxima in the ultraviolet spectrum at 326
and 341 nm) which was used for the next step without any further
purification. The resin was dissolved in 200 ml of methylene chloride, 10 ml of
glacial acetic acid were added to the solution, and the mixture was cooled to -
40°C in a carbon dioxide atmosphere, while stirring. Then, 9 ml of aqueous
hydrobromic acid (60%) were added in one portion, the mixture was stirred at
-35°C for 1.5 minutes, and subsequently 200 ml of ice water were run into
the mixture. After further stirring the mixture for 2 hours at 0°C, the
methylene chloride layer was separated, washed with water and sodium
bicarbonate solution, dried with Na2SO4 andconcentrated in vacuo. The
residue, i.e., 11,12-11',12'-bisdehydro-betta-carotene, was a tough resin or a
foamy solid (having no active hydrogen atoms and possessing absorption
maxima in the ultraviolet spectrum at 334 and 408 nm). This product can be
purified by chromatography. The crude product can also be used for the next
step without any preliminary purification.
11.4 g of 11,12-11',12'-bisdehydro-β-carotene were dissolved in 100 ml of
petroleum ether (boiling range 80° to100°C), and the solution was
hydrogenated under normal conditions after the addition of 0.5 ml of quinoline
and 5 g of a lead-poisoned palladium catalyst. After the calculated amount of
hydrogen had been absorbed, the catalyst was removed by filtration and the
filtrate was extracted with dilute sulfuric acid to remove the quinoline. By
concentrating the solution in the usual manner there was obtained 11,12-
11',12'-di-cis-carotene. The product was purified by recrystallization from
benzene-alcohol. The purified product melts at 154°C; absorption maxima in
the ultraviolet spectrum at 276, 334, 338, 401 and 405 nm. The isomerization
was effected by heating the product for 10 hours at 90 to 100°C in high-boiling petroleum ether in a carbon dioxide atmosphere. The resulting and carotene melted at 180°C; ultraviolet absorption maxima at 452 and 480 nm.
Preparation of the intermediates for the above chemical synthesis are also
described in US. Patent 2,917,539. The other patents cited below describe a
fermentation route. US Patent 2,848,508 describes preparation from carrots.
brand name
BetaVit (BASF); Lucaratin (BASF); Solatene (Hoffmann-LaRoche).
Therapeutic Function
Vitamin A precursor, Sunscreen agent
General Description
beta-Carotene is an antioxidant and is one of the most important carotenoids and a source of vitamin A. It is abundantly present in fruits and vegetables which is also used as a food supplement and a colorant.
Biochem/physiol Actions
The most important of the provitamins A, β-carotene can be classified as an antioxidant due to its inhibition of radical initiated peroxidation in vitro. However, in vivo it appears to act either as an antioxidant or a prooxidant depending on cellular environment. It reduces the incidence of many cancers, but enhances lung cancer incidence in smokers.
Side effects
Side effects from β-Carotene include: Skin discoloration (yellowing that eventually goes away); Loose stools; Bruising; Joint pain.
Safety Profile
When heated to decomposition it emits acrid smoke and irritating fumes.
Source
The richest sources of β-Carotene are yellow, orange, and green leafy fruits and vegetables (such as carrots, spinach, lettuce, tomatoes, sweet potatoes, broccoli, cantaloupe, and winter squash). In general, the more intense the color of the fruit or vegetable, the more beta-carotene it has.
Purification Methods
It forms purple prisms when crystallised from *C6H6/MeOH and red rhombs from pet ether. Its solubility in hexane is 0.1% at 0o. It is oxygen sensitive and should be stored under N2 at -20o in the dark. It gives a deep blue colour with λmax at 590nm when mixed with SbCl3 in CHCl3. UV: (*C6H6) 429infl, max at 454 and 484nm. The principal peak at 454nm has 1cm 1% 2000. [Synthesis: Surmatis & Ofner J Org Chem 26 1171 1961; Milas et al. J Am Chem Soc 72 4844 1950.] β-Carotene is also purified by column chromatography (Al2O3 activity I-II). It is dissolved in pet ether/*C6H6 (10:1), applied to the column and eluted with pet ether/EtOH; the desired fraction is evaporated and the residue is recrystallised from *C6H6/MeOH (violet-red plates). [UV: Inhoffen et al. Justus Liebigs Ann Chem 570 54, 68 1950; Review: Fleming Selected Organic Synthesis (J Wiley, Lond) pp. 70-74 1973.] Alternatively it can be purified by chromatography on a magnesia column, thin layer of Kieselguhr or magnesia. Crystallise it from CS2/MeOH, Et2O/pet ether, acetone/pet ether or toluene/MeOH. Store it in the dark, under an inert atmosphere, at -20o. Recrystallise it also from 1:1 EtOH/CHCl3. [Bobrowski & Das J Phys Chem 89 5079 1985, Johnston & Scaiano J Am Chem Soc 1 0 8 2349 1986, Strain J Biol Chem 105 523 1934, Meth Biochem Anal 4 1 1957, Beilstein 5 II 638, 5 III 2453, 5 IV 2617.]
β-Carotene Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Xi'an ZB Biotech Co.,Ltd | +8618591943808 | sales01@xazbbio.com | China | 815 | 58 |
| Sinoway Industrial co., ltd. | 0592-5800732; +8613806035118 | xie@china-sinoway.com | China | 988 | 58 |
| TAIZHOU YUXIN BIOTECHNOLOGY CO,.LTD | +86-576-88902229;+86-0576-88902229 +8613968687450 | yuxin@yuxchem.com | China | 167 | 58 |
| Hangzhou Zelixir Biotech Co., Ltd. | +8618867646786 | neal.chen@zelixir.com | China | 232 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
| Hebei Weibang Biotechnology Co., Ltd | +8615531157085 | abby@weibangbio.com | China | 8810 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5892 | 58 |
| Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 | qinhe02@xaltbio.com | China | 997 | 58 |
| Wuhan Marco Pharmaceutical Technology Co., Ltd. | +86-18572802410 +86-18572802410 | sales@marcopht.com | China | 30 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 3002 | 58 |
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View Lastest Price from β-Carotene manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-28 | β-Carotene
7235-40-7
|
US $500.00-300.00 / kg | 1kg | 99% | 5000 | HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | |
 |
2024-11-28 | Beta-Carotene
7235-40-7
|
US $0.00 / Kg/Bag | 2Kg/Bag | 99% up, High Density | 20 tons | Sinoway Industrial co., ltd. | |
 |
2024-11-28 | beta-Carotene
7235-40-7
|
US $0.00 / Kg/Bag | 1KG | 1%,10%,20%,96% | 2000mt | Jinan Finer Chemical Co., Ltd |
-
- β-Carotene
7235-40-7
- US $500.00-300.00 / kg
- 99%
- HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
-
- Beta-Carotene
7235-40-7
- US $0.00 / Kg/Bag
- 99% up, High Density
- Sinoway Industrial co., ltd.
-
- beta-Carotene
7235-40-7
- US $0.00 / Kg/Bag
- 1%,10%,20%,96%
- Jinan Finer Chemical Co., Ltd
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