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avosentan

avosentan structure

CAS No.: 290815-26-8

Chemical Name:: avosentan

Synonyms: CS-644;SPP-301;avosentan;Ro 67-0565;Avosentan (SPP301);RO 67-0565; SPP-301;Avosentan (Ro 67-0565;avosentan,CID 9912992;inhibit,SPP 301,Inhibitor,Avosentan,SPP301,Endothelin Receptor;N-(6-Methoxy-5-(2-methoxyphenoxy)-2-(pyridin-4-yl)-pyrimidin-4-yl)-5-methylpyridine-2-sulfonam

CBNumber:: CB41508589

Molecular Formula:: C23H21N5O5S

Molecular Weight:: 479.51

MDL Number:: MFCD23843806

MOL File:: 290815-26-8.mol

Last updated:2023-09-04 15:51:00

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avosentan Properties

Boiling point	575.5±60.0 °C(Predicted)
Density	1.363
storage temp.	Store at -20°C
solubility	DMSO : 6.67 mg/mL (13.91 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
form	Powder
pka	3.19±0.10(Predicted)
FDA UNII	L94KSX715K

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P264-P270-P301+P312-P330-P501

avosentan price More Price(14)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	A794710	Avosentan	290815-26-8	10mg	$165	2021-12-16	Buy
Usbiological	002983	Avosentan	290815-26-8	10mg	$460	2021-12-16	Buy
ChemScene	CS-0625	Avosentan 98.36%	290815-26-8	10mg	$180	2021-12-16	Buy
Matrix Scientific	098678	N-(6-Methoxy-5-(2-methoxyphenoxy)-2-(pyridin-4-yl)-pyrimidin-4-yl)-5-methylpyridine-2-sulfonamide 95+%	290815-26-8	250mg	$742	2021-12-16	Buy
ChemScene	CS-0625	Avosentan 98.36%	290815-26-8	50mg	$840	2021-12-16	Buy

Product number	Packaging	Price	Buy
A794710	10mg	$165	Buy
002983	10mg	$460	Buy
CS-0625	10mg	$180	Buy
098678	250mg	$742	Buy
CS-0625	50mg	$840	Buy

avosentan Chemical Properties,Uses,Production

Uses

Avosentan is a competitive antagonist of Endothelin-1 (ET-1) with a high selectivity for the ETA receptor. Avosentan may be a potential option in the treatment of glaucoma.

Enzyme inhibitor

This potent, selective and orally available endothelin A receptor blocker (FW = 479.51 g/mol; CAS 290815-26-8; Soluble in DMSO), also known by its code names SPP301 and Ro 67-0565, induces the dose-dependent reduction in the fractional renal excretion of sodium (up to 8.7% at 50 mg avosentan), with a paralleled dose-related increase in proximal sodium reabsorption. Avosentan reduces albuminuria, when added to standard treatment in patients with type 2 diabetes and overt nephropathy, but induces significant fluid overload and congestive heart failure.

avosentan Preparation Products And Raw materials

Raw materials

Preparation Products

avosentan Suppliers

Global( 67)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
GIHI CHEMICALS CO.,LIMITED	+8618058761490	info@gihichemicals.com	China	50000	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	96815	76
Chembest Research Laboratories Limited	021-20908456	sales@BioChemBest.com	China	6011	61
LGM Pharma	1-(800)-881-8210	inquiries@lgmpharma.com	United States	2127	70
Chemsky (shanghai) International Co.,Ltd	021-50135380	shchemsky@sina.com	China	15421	60
Haoyuan Chemexpress Co., Ltd.	021-58950125	info@chemexpress.com	China	7553	61
MedChemexpress LLC	021-58955995	sales@medchemexpress.cn	United States	4863	58

Supplier	Advantage
Career Henan Chemica Co	58
GIHI CHEMICALS CO.,LIMITED	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58
J & K SCIENTIFIC LTD.	76
Chembest Research Laboratories Limited	61
LGM Pharma	70
Chemsky (shanghai) International Co.,Ltd	60
Haoyuan Chemexpress Co., Ltd.	61
MedChemexpress LLC	58

avosentan Spectrum

avosentan(290815-26-8)¹HNMR

290815-26-8(avosentan)Related Search:

p-Anisidine 5-METHYL-N,N-DIMETHYLTRYPTAMINE N-Methoxyphthalimide 4-Methoxybenzyl cyanide

N-(6-Methoxy-5-(2-methoxyphenoxy)-2-(pyridin-4-yl)-pyrimidin-4-yl)-5-methylpyridine-2-sulfonamide N-(6-Methoxy-5-(2-methoxyphenoxy)-2-(pyridin-4-yl)-pyrimidin-4-yl)-5-methylpyridine-2-sulfonam 2-Pyridinesulfonamide,N-[6-methoxy-5-(2-methoxyphenoxy)-2-(4-pyridinyl)-4-pyrimidinyl]-5-methyl- avosentan N-[6-Methoxy-5-(2-methoxyphenoxy)-2-(4-pyridinyl)-4-pyrimidinyl]-5-methyl-2-pyridinesulfonamide Ro 67-0565 SPP-301 Avosentan (SPP301) CS-644 Avosentan (Ro 67-0565 RO 67-0565; SPP-301 avosentan,CID 9912992 inhibit,SPP 301,Inhibitor,Avosentan,SPP301,Endothelin Receptor 290815-26-8 C23H21N5O5S