PUROMYCIN DIHYDROCHLORIDE

PUROMYCIN DIHYDROCHLORIDE Properties

Melting point	168-170℃
storage temp.	Inert atmosphere,Store in freezer, under -20°C
solubility	H2O: soluble50mg/mL (Sterilize stock solution by filtration using 0.22 μm filter then store in aliquots at 20 °C.)
form	solution
color	yellow-white
Water Solubility	Soluble in water
Merck	14,7943
BRN	3853613
Stability	Stable. Heat sensitive. Incompatible with strong oxidizing agents.
InChIKey	MKSVFGKWZLUTTO-NGOAXYITSA-N
FDA UNII	PGN54228S5
EPA Substance Registry System	Adenosine, 3'-[[(2S)-2-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyl-, dihydrochloride (58-58-2)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

Hazard Codes

Risk Statements

Safety Statements

RIDADR

3249

WGK Germany

3

RTECS

AU7355000

F

3-8-10

HazardClass

6.1(b)

PackingGroup

III

HS Code

29419090

Toxicity

LD50 oral in guinea pig: 600mg/kg

NFPA 704

	0
1		0

PUROMYCIN DIHYDROCHLORIDE price More Price(48)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	P7255	Puromycin dihydrochloride from Streptomyces alboniger ≥98% (HPLC), powder	58-58-2	25mg	$86.9	2024-03-01	Buy
Sigma-Aldrich	P7255	Puromycin dihydrochloride from Streptomyces alboniger ≥98% (HPLC), powder	58-58-2	1g	$1980	2024-03-01	Buy
Sigma-Aldrich	540411	Puromycin, Dihydrochloride, Cell Culture-Tested - CAS 58-58-2 - Calbiochem Puromycin, CAS 58-58-2, is a protein synthesis inhibitor that causes premature release of nascent polypeptide chains.	58-58-2	25MG	$92.2	2022-05-15	Buy
Sigma-Aldrich	540411	Puromycin, Dihydrochloride, Cell Culture-Tested - CAS 58-58-2 - Calbiochem Puromycin, CAS 58-58-2, is a protein synthesis inhibitor that causes premature release of nascent polypeptide chains.	58-58-2	100MG	$280	2022-05-15	Buy
Sigma-Aldrich	540222	Puromycin, Dihydrochloride - CAS 58-58-2 - Calbiochem	58-58-2	25MG	$78.9	2022-05-15	Buy

Product number	Packaging	Price	Buy
P7255	25mg	$86.9	Buy
P7255	1g	$1980	Buy
540411	25MG	$92.2	Buy
540411	100MG	$280	Buy
540222	25MG	$78.9	Buy

PUROMYCIN DIHYDROCHLORIDE Chemical Properties,Uses,Production

Description

Puromycin (58-58-2) is an aminonucleoside antibiotic derived from Streptomyces alboniger. It is a protein synthesis inhibitor that disrupts peptide transfer on ribosomes causing premature chain termination.1 It is an inhibitor of dipeptidyl-peptidase II and cytosolic alanyl aminopeptidase.2 Puromycin also inhibits protein transport in mitochondria.3

Chemical Properties

white powder

Uses

Puromycin dihydrochloride is the salt of puromycin, a nucleoside antibiotic isolated from Streptomyces alboniger in the 1950s as an anti-trypansomal agent with antibiotic activity. While the salt shares the same pharmacological properties as puromycin free base, its greater water solubility offers advantages in some in vitro applications. Physicochemical properties and chromatographic behaviour will depend on whether the pH is buffered. In non-pH controlled systems, the free base and salt may behave differently.

Uses

Research tool for studying protein synthesis; cell line selection agent in gene transfer experiments.

Uses

Puromycin is an aminonucleoside antibitotic. Puromycin acts as a protein synthesis inhibitor which interferes with translation by inhibiting ribosome functions. Puromycin is also a reversible inhibitor of dipeptidyl-peptidase II (serine peptidase) and cytosol alanyl aminopeptidase.

Uses

An aminonuclease antibiotic used for selection and maintenance of cell lines expressing a transfected pac gene.

Uses

antibacterial

Uses

Puromycin dihydrochloride is a salt of puromycin, a nucleoside antibiotic isolated from Streptomyces alboniger in the 1950s as an anti-trypansomal agent with antibiotic activity. While the salt shares the same pharmacological properties as puromycin free base, its greater water solubility offers advantages in some in vitro applications. Physicochemical properties and chromatographic behaviour will depend on whether the pH is buffered. In non-pH controlled systems, the free base and salt may behave differently.

General Description

White powder.

Air & Water Reactions

Water soluble.

Reactivity Profile

PUROMYCIN DIHYDROCHLORIDE is sensitive to prolonged exposure to heat. . Behaves as a very weak acid in solution.

Fire Hazard

Flash point data for PUROMYCIN DIHYDROCHLORIDE are not available, but PUROMYCIN DIHYDROCHLORIDE is probably combustible.

storage

-20°C

Purification Methods

Puromycin dihydrochloride is purified by recrystallisation from H2O. The free base, [58-60-6] M 294.3, has m 175.5-177o (172-173o) (from H2O). The sulfate has m 180-187o dec (from H2O), and the picrate monohydrate has m 146-149o (from H2O). [Baker et al. J Am Chem Soc 77 1 1955, Fryth et al. J Am Chem Soc 80 3736 1958.] It is an inhibitor of aminopeptidase and terminates protein synthesis [Reboud et al. Biochemistry 20 5281 1981]. [Beilstein 26 III/IV 3704.]

References

1) Azzam and Algranati; (1973) Mechanism of puromycin action: fate of ribosomes after release of nascent polypeptide chains from polysomes; Proc. Nat. Acad. Sci. USA, 70 3866 2) Bhutani et al. (2007) Puromycin-sensitive aminopeptidase is the major peptidase responsible for digesting polyglutamine sequences by proteasomes during protein degradation; EMBO J., 26 1385 3) Price and Verner (1993) Puromycin inhibits protein import into mitochondria by interfering with an intramitochondrial ATP-dependent reaction; Biochim. Biophys. Acta, 1150 89

PUROMYCIN DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

PUROMYCIN DIHYDROCHLORIDE Suppliers

Global( 293)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29884	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49374	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32165	58
Hubei Ipure Biology Co., Ltd	+8613367258412	ada@ipurechemical.com	China	10319	58
HONG KONG IPURE BIOLOGY CO.,LIMITED	86 18062405514 18062405514	ada@ipurechemical.com	CHINA	3461	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23541	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	7724	58
AFINE CHEMICALS LIMITED	+86-0571-85134551	sales@afinechem.com	China	15354	58
Baoji Guokang Bio-Technology Co., Ltd.	0917-3909592 13892490616	gksales1@gk-bio.com	China	9314	58

Supplier	Advantage
career henan chemical co	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
TargetMol Chemicals Inc.	58
Hubei Ipure Biology Co., Ltd	58
HONG KONG IPURE BIOLOGY CO.,LIMITED	58
ANHUI WITOP BIOTECH CO., LTD	58
Shaanxi Dideu Medichem Co. Ltd	58
AFINE CHEMICALS LIMITED	58
Baoji Guokang Bio-Technology Co., Ltd.	58

View Lastest Price from PUROMYCIN DIHYDROCHLORIDE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-19	Puromycin dihydrochloride 58-58-2	US $39.00-122.00 / mg		99.86%	10g	TargetMol Chemicals Inc.
2021-07-13	PUROMYCIN DIHYDROCHLORIDE 58-58-2	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2021-07-10	PUROMYCIN DIHYDROCHLORIDE 58-58-2	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd

Puromycin dihydrochloride
58-58-2
US $39.00-122.00 / mg
99.86%
TargetMol Chemicals Inc.

PUROMYCIN DIHYDROCHLORIDE
58-58-2
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

PUROMYCIN DIHYDROCHLORIDE
58-58-2
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

PUROMYCIN DIHYDROCHLORIDE Spectrum

PUROMYCIN DIHYDROCHLORIDE(58-58-2)MS PUROMYCIN DIHYDROCHLORIDE(58-58-2)¹HNMR PUROMYCIN DIHYDROCHLORIDE(58-58-2)IR PUROMYCIN DIHYDROCHLORIDE(58-58-2)Raman

58-58-2(PUROMYCIN DIHYDROCHLORIDE)Related Search:

PUROMYCIN(RG),PUROMYCIN (S)-TETRAHYDROFURAN-3-AMINE HYDROCHLORIDE (S)-3-AMINOTETRAHYDROFURAN TETRAHYDRO-FURAN-3-YLAMINE HCL PUROMYCIN DIHYDROCHLORIDE

Adenine hydrochloride hemihydrate Adenine hydrochloride Adenine Sulfate N-(3-Aminopropyl)-imidazole 6-Dimethylaminopurine

PUROMYCIN DIHYDROCHLORIDE,PUROMYCIN 2HCL,PUROMYCIN DIHYDROCHLORIDE,PUROMYCIN 3'-Amino-2',3'-dideoxyadenosine PUROMYCIN AMINONUCLEOSIDE,Puromycin Aminonucleoside, 6-Dimethylamin-9-[3-amino-3deoxyribosyl]-purine Cyclopenthiazide 3-N-PROPYL-TETRAHYDROFURAN-3-YL-AMINE HYDROCHLORIDE

3'-AMINO-D-ADENOSINE H-TYR-NH2 HCL 3-(IMIDAZOLE-1-YL)-PROPYLAMINE DIHYDROCHLORIDE

1of4

Puromycin dihydrochloride hydrate,99% 3’-(alpha-amino-p-methoxyhydrocinnamamido)-3’-deoxy-n,n-dimethyl-adenosin adenosine,3’-((2-amino-3-(4-methoxyphenyl)-1-oxopropyl)amino)-3’-deoxy-n,n-dim dihydrochloride,(s)-ethyl PUROMYCIN Dihydrochloride Dihydrate 96% 3'-[[12-AMINO-3-(4-METHOXYPHENYL)-1-OXOPROPYL]AMINO]-3'-DEOXY-N,N-DIMETHYL-ADENOSINE 2HCL 3'-[[2-AMINO-3-(4-METHOXYPHENYL)-1-OXOPROPYL]AMINO]-3'-DEOXY-N,N-DIMETHYLADENOSINE DIHYDROCHLORIDE 3'-[[2-AMINO-3-(4-METHOXYPHENYL)-1-OXOPROPYL]AMINO]-3'-DEOXY-N,N-DIMETHYL-ADENOSINE 2HCL 3'-(A-AMINO-P-METHOXYHYDROCINNAMAMIDO)-3'-DEOXY-N,N-DIMETHYLADENOSINE DIHYDROCHLORIDE 3'-(A-AMINO-P-METHOXY-HYDOCINNAMAMIDO)-3'-DEXOY-N,N-DIMETHYLADENOSINE 2HCL 3'-(ALPHA-AMINO-P-METHOXY-HYDROCINNAMINO-3'-DEOXY-N,N-DIMETHY-ADENOSINE) 2HCL 3'-(ALPHA-AMINO-P-METHOXY-HYDROCINNAMIDO-3'-DEOXY-N,N-DIMETHYL-ADENOSINE) 2HCL 3'-[ALPHA-AMINO-P-METHOXYHYDROCINNAMAMIDO]-3'-DEOXY-N,N-DIMETHYLADENOSINE DIHYDROCHLORIDE 3'-(ALPHA-AMINO-P-METHOXYHYDROCINNAMAMIDO)-3'-DEOXY-N,N-DIMETHYLADENOSINE, 2HCL 3'-(ALPHA-AMINO-P-METHOXYHYDROCINNAMADIO)-3'-DEOXY-N,N-DIMETHYLADENOSINE DIHYDROCHLORIDE PUROMYCIN, CELL CULTURE TESTED Puromycin, 3-[[2-Amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3-deoxy-N,N-dimethyladenosine dihydrochloride Puromycin hydrate dihydrochloride PuroMycin dihydrochloride hydrate, 99% 10MG PuroMycin dihydrochlorid Puromycin dihydrochloride (animal free) StyloMycin dihydrochloride, CL 13900 dihydrochloride, CL16536, NSC 3055, P638 dihydrochloride. 3'-[[(2S)-2-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyl-adenosine,hydrochloride (1:2) Puromycin 2HCl (S)-3'-[[2-Amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyladenosine dihydrochloride Puromycin dihydrochloride (S)-3'-[[2-Amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyladenosine dihydrochloride Puromycin 2hydrochloride -2-Amino-N-((2S,3S,4R,5R) -4-hydroxy-2-(hydroxymethyl) -5-(6-(dimethylamino) -9H-purin-9-yl) propanamide dihydrochloride tetrahydrofuran-3-yl) PUROMYCIN DIHYDROCHLORIDE (S) 3'-[[2-AMINO-3-(4-METHOXYPHENYL)-1-OXOPROPYL]AMINO]-3'-DEOXY-N,N-DIMETHYLADENOSINE 2HCL (S)-3'-[2-AMINO-3-(4-METHOXYPHENYL)-1-OXOPROPYL]AMINO]-3'-DEOXY-N,N-DIMETHYLADENOSINE l-2hc puromycinhydrochloride stylomycinhydrochloride PUROMYCIN DIHYDROCHLORIDE CELL*CULTURE T ESTED PUROMYCIN READY MADE SOLUTION PUROMYCIN DIHYDROCHLORIDE FROM STREPTO-M YCES ALBO-NIGER (S)-3'-[[2-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyladenosine dihydrochloride PUROMYCIN DIHYDROCHLORIDE CELL CULTURE REAGENT PUROMYCIN DIHYDROCHLORIDE ULTRA PURE GRADE 98+% Puromycin.Cellculturedtested Puromycin,Solution,CellCultureTested Adenosine, 3-(2S)-2-amino-3-(4-methoxyphenyl)-1-oxopropylamino-3-deoxy-N,N-dimethyl-, dihydrochloride 3'-[α-amino-p-methoxyhydrocinnamamido]-3'-deoxy-n,n-dimethyladenosine dihydrochloride PUROMYCINDIHYROCHLORIDE DIHYDROGEN PUROMYCIN DICHLORIDE Puromycin dihydrochL CL 13900 dihydrochloride P638 dihydrochloride STYLOMYCIN HYDROCHLORIDE; CL 13900 DIHYDROCHLORIDE; CL16536; NSC 3055; P638 DIHYDROCHLORIDE PUROMYCIN DIHYDROCHLORIDE USP/EP/BP abs9143 (S)-2-Amino-N-((2S,3S,4R,5R)-5-(6-(Dimethylamino)-9H-purin-9-yl)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl)-3-(4-methoxyphenyl)propanamide dihydrochloride Puromycin 2HCl (CL13900)