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Pemetrexed

Pemetrexed structure

CAS No.: 137281-23-3

Chemical Name:: Pemetrexed

Synonyms: PEMETREXED;(S)-2-(4-(2-(2-AMino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl)benzaMido)pentanedioic acid;Premetred;PEMETREXED;Pemetrexedum;Pemetrexed99%;Pemetrexedaci;(R)-Pemetrexed;PeMetrexed-15C5;PeMetrexed-13C5

CBNumber:: CB4170583

Molecular Formula:: C20H21N5O6

Molecular Weight:: 427.41

MDL Number:: MFCD00902635

MOL File:: 137281-23-3.mol

Last updated:2024-11-19 15:53:33

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Pemetrexed Properties

Density	1.59±0.1 g/cm3(Predicted)
storage temp.	2-8°C(protect from light)
solubility	slightly sol. in Methanol
form	powder to crystal
pka	3.58±0.10(Predicted)
color	White to Blue
Merck	14,7077
CAS DataBase Reference	137281-23-3(CAS DataBase Reference)
FDA UNII	04Q9AIZ7NO
ATC code	L01BA04

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H332-H335
Precautionary statements	P261-P280-P305+P351+P338
RTECS	LZ9950100
HS Code	2933.99.9701

Pemetrexed price More Price(38)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	P2288	Pemetrexed Hydrate >98.0%(HPLC)(T)	137281-23-3	250mg	$80	2024-03-01	Buy
TCI Chemical	P2288	Pemetrexed Hydrate >98.0%(HPLC)(T)	137281-23-3	1g	$200	2024-03-01	Buy
Tocris	6185	Pemetrexed ≥98%(HPLC)	137281-23-3	50	$63	2021-12-16	Buy
TRC	A604980	N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamicAcid	137281-23-3	250mg	$130	2021-12-16	Buy
Biosynth Carbosynth	BP164240	Pemetrexed	137281-23-3	100mg	$135	2021-12-16	Buy

Product number	Packaging	Price	Buy
P2288	250mg	$80	Buy
P2288	1g	$200	Buy
6185	50	$63	Buy
A604980	250mg	$130	Buy
BP164240	100mg	$135	Buy

Pemetrexed Chemical Properties,Uses,Production

Chemical Properties

N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid disodium salt is Off-White Solid

Uses

Pemetrexed is used in the treatment of malignant pleural mesothelioma (MPM) and erectile dysfunction therapy.

Definition

ChEBI: Pemetrexed is an N-acylglutamic acid in which the N-acyl group is specified as 4-[2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl. Inhibits thymidylate synthase (TS), 421 dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT). It has a role as an antineoplastic agent, an antimetabolite, an EC 2.1.1.45 (thymidylate synthase) inhibitor, an EC 1.5.1.3 (dihydrofolate reductase) inhibitor and an EC 2.1.2.2 (phosphoribosylglycinamide formyltransferase) inhibitor. It is a pyrrolopyrimidine and a N-acyl-L-glutamic acid. It is a conjugate acid of a pemetrexed(2-).

brand name

Alimta (Lilly).

Side effects

The most common side effects for pemetrexed include fatigue, nausea, vomiting, anorexia, mucositis, myelosuppression ± infection, bleeding, rash, diarrhea and ↑ LFTs.
Severe myelosuppression is often dose-limiting for pemetrexed. Sepsis, in some cases fatal, have occurred in approximately 1% of patients in clinical trials. Prophylactic folic acid and intramuscular vitamin B12 supplements are necessary to reduce hematologic or non-hematologic toxicities.
Pemetrexed may cause serious and in some cases fatal dermatologic toxicities. Rarely, StevensJohnson syndrome and toxic epidermal necrolysis have been reported.

storage

Store at +4°C

Mode of action

Pemetrexed is a pyrrolopyrimidine antifolate that exerts its antineoplastic activity by inhibiting thymidylate synthase (TS), glycinamide ribonucleotide formyltransferase (GARFT) and dihydrofolate reductase (DHFR), which are involved in folate metabolism and DNA synthesis, resulting in inhibition of purine and thymidine nucleotide synthesis.

Pemetrexed synthesis

Synthesis of Pemetrexed from N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid 1,5-diethyl ester 4-methylbenzenesulfonate

Pemetrexed Preparation Products And Raw materials

Raw materials

Preparation Products

Pemetrexed Suppliers

Global( 361)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Jinan Million Pharmaceutical Co., Ltd	0531-68659554 +8613031714605	info@millionpharm.com	China	252	58
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	18775	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21634	55
Hangzhou FandaChem Co.,Ltd.	+8615858145714	FandaChem@Gmail.com	China	9206	55
Lianyungang happen teng technology co., LTD	15950718863	wang666xt@163.com	CHINA	295	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29881	58
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	965	58
Jinan Shengqi pharmaceutical Co,Ltd	86+18663751872	christine@shengqipharm.com	CHINA	491	58
Jinan Finer Chemical Co., Ltd	+86-531-88989536 +86-15508631887	sales@finerchem.com	China	2963	58
Hebei Jimi Trading Co., Ltd.	+86 319 5273535	bestoneforyou@sina.com	CHINA	287	58

Supplier	Advantage
Jinan Million Pharmaceutical Co., Ltd	58
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
Lianyungang happen teng technology co., LTD	58
career henan chemical co	58
Biochempartner	58
Jinan Shengqi pharmaceutical Co,Ltd	58
Jinan Finer Chemical Co., Ltd	58
Hebei Jimi Trading Co., Ltd.	58

View Lastest Price from Pemetrexed manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-28	Pemetrexed 137281-23-3	US $2.54 / kg	1kg	99.49	60 tons	Jinan Million Pharmaceutical Co., Ltd
2024-11-19	Pemetrexed 137281-23-3	US $33.00-66.00 / mg		99.96%	10g	TargetMol Chemicals Inc.
2024-11-19	Pemetrexed 137281-23-3	US $33.00-66.00 / mg		99.96%	10g	TargetMol Chemicals Inc.

Pemetrexed
137281-23-3
US $2.54 / kg
99.49
Jinan Million Pharmaceutical Co., Ltd

Pemetrexed
137281-23-3
US $33.00-66.00 / mg
99.96%
TargetMol Chemicals Inc.

Pemetrexed
137281-23-3
US $33.00-66.00 / mg
99.96%
TargetMol Chemicals Inc.

Pemetrexed Spectrum

Pemetrexed(137281-23-3)¹HNMR

137281-23-3(Pemetrexed)Related Search:

Pemetrexed Disodium Pemetrexed disodium hemipentahydrate Pemetrexed Pyrrolo[2,3-d]pyrimidin-4-ol 2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine

CHEMBRDG-BB 9071517 2-AMINO-5-METHYL-3,7-DIHYDRO-4H-PYRROLO[2,3-D]PYRIMIDIN-4-ONE CHEMBRDG-BB 9071952 CHEMBRDG-BB 9071469

1of2

PeMetrexed-13C5 PeMetrexed-15C5 N-[4-[2-(2-aMino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl]benzoyl]L-GlutaMic acid (PeMetrexed acid) N-[4-[2-(2-AMino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl]benzoyl]-L-glutaMic acid (S)-2-(4-(2-(2-Amino-4-oxo-4,7-dihydro-1H-pyrrolo-[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedi N-[4-[2-(2-Amino-4,7 (2R)-2-{[4-(2-{2-aMino-4-oxo-1H,4H,7H-pyrrolo[2,3-d]pyriMidin-5-yl}ethyl)phenyl]forMaMido}pentanedioic acid N-(4- 2-(2-AMino-4,7-Dihydro-4-oxo-1H-pyrrol... PeMetrexed disodiuM INT-6 (S)-2-(4-(2-(2-AMino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl)benzaMido)pentanedioic acid The sour sour of the United States Pemetrexed Hydrate Pemetrexed - Labeled 15N,13C5 (R)-Pemetrexed (S)-2-(4-(2-(2-Amino-4-oxo-4,7-dihydro-1H-pyrrolo-[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentan PEMETREXED ACID PEMETREXED N-(4-[2-(2-Amino-4,7-Dihydro-4-oxo-1H-pyrrolo)[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-Gluamic Acid Pemetrexed99% L-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]- N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid disodium salt PEFLOXACINMESYLATE Premetred disodium Pemetrexedum Premetred PemetrexedHydrate> (S)-2-(4-(2-(2-Amino-4-oxo-4,7-dihydro-3H-pyrroL )benzamido)pentanedioic acid 3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid disodium salt N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidi... PemetrexedQ: What is Pemetrexed Q: What is the CAS Number of Pemetrexed Q: What is the storage condition of Pemetrexed Q: What are the applications of Pemetrexed PEMETREXED (S)-2-(4-(2-(2-AMino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl)benzaMido)pentanedioic acid Pemetrexedaci 137281-23-3 C20H21N5O6xH2O Anti-cancer & immunity API CIALIS