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DL-BUTHIONINE-[S,R]-SULFOXIMINE

DL-BUTHIONINE-[S,R]-SULFOXIMINE structure

CAS No.: 5072-26-4

Chemical Name:: DL-BUTHIONINE-[S,R]-SULFOXIMINE

Synonyms: NSC 381100;butioninesulfoximine;buthioninesulfoximine;buthioninesulfoxamine;buthioninesulphoximine;DL-BUTHIONINE-SULFOXIMINE;DL-BUTHIONINE (S,R)-SULPHOXIME;DL-BUTHIONINE-[S,R]-SULFOXIMINE;DL-BUTHIONINE (R,S)-SULFOXIMINE;DL-Buthionine (S,R)-sulfoximine,99%

CBNumber:: CB4184630

Molecular Formula:: C8H18N2O3S

Molecular Weight:: 222.31

MDL Number:: MFCD00070309

MOL File:: 5072-26-4.mol

MSDS File:: SDS

Last updated:2024-11-20 11:41:24

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DL-BUTHIONINE-[S,R]-SULFOXIMINE Properties

Melting point	215 °C (dec.)(lit.)
Boiling point	382.3±52.0 °C(Predicted)
Density	1.29±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	H₂O: 50 mg/mL, clear, colorless
form	Fluffy Powder
color	White
Merck	13,1520
BRN	2367136
CAS DataBase Reference	5072-26-4(CAS DataBase Reference)
FDA UNII	LW4108Q0BV
NCI Dictionary of Cancer Terms	buthionine sulfoximine
NCI Drug Dictionary	buthionine sulfoximine

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

RTECS

EK7713435

HS Code

29309090

NFPA 704

	0
2		0

DL-BUTHIONINE-[S,R]-SULFOXIMINE price More Price(27)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	19176	DL-Buthionine-sulfoximine ≥99.0% (TLC)	5072-26-4	1g	$331	2024-03-01	Buy
Sigma-Aldrich	19176	DL-Buthionine-sulfoximine ≥99.0% (TLC)	5072-26-4	5g	$690	2024-03-01	Buy
Cayman Chemical	23691	D,L-Buthionine-(S,R)-sulfoximine ≥98%	5072-26-4	250mg	$68	2024-03-01	Buy
Cayman Chemical	23691	D,L-Buthionine-(S,R)-sulfoximine ≥98%	5072-26-4	500mg	$116	2024-03-01	Buy
Sigma-Aldrich	B2640	DL-Buthionine-(S,R)-sulfoximine	5072-26-4	500mg	$138	2024-03-01	Buy

Product number	Packaging	Price	Buy
19176	1g	$331	Buy
19176	5g	$690	Buy
23691	250mg	$68	Buy
23691	500mg	$116	Buy
B2640	500mg	$138	Buy

DL-BUTHIONINE-[S,R]-SULFOXIMINE Chemical Properties,Uses,Production

Chemical Properties

White Crystalline Solid

Uses

DL-Buthionine-sulfoximine is suitable for use to:

examine whether the inhibition of glutathione by BSO enhances the apoptotic effect of estrogen on antihormone-resistant human breast cancer cells
investigate the effect of BSO on development of bovine embryos
inhibit GSH in several studies
investigate the effect of GSH synthesis on oocyte maturation

It may be used to inhibit GSH and evaluate the hepatotoxicity and nephrotoxicity of natural food colorants in the absence of GSH

Uses

A potent and specific inhibitor of alpha-glutamyl cysteine synthetase

Uses

Biological tool for depletion of glutathione.

Definition

ChEBI: A sulfoximide that is the sulfoximine derivative of an analogue of DL-methionine in which the S-methyl group is replaced by S-butyl.

General Description

DL-buthionine-SR-sulfoximine (BSO) is an amino acid analogue, which acts as an inhibitor of γ-glutamylcysteine synthetase. BSO increases the sensitivity of Trypanosoma cruzi to antiparasitic drugs, such as nifurtimox or benznidazole.

Biochem/physiol Actions

DL-Buthionine-sulfoximine inhibits the biosynthesis of Glutathione (GSH) in liver and other peripheral organs. It does not have any effect on GSH in the CNS. It augments the antiproliferative action of reactive oxygen species (e.g., hydrogen peroxide), and agents that indirectly cause accumulation of reactive oxygen species (e.g., 2-methoxyestradiol, which increases intracellular superoxide anion).

DL-BUTHIONINE-[S,R]-SULFOXIMINE Preparation Products And Raw materials

Raw materials

Preparation Products

Ethyl 5-[3-(4,6-dimethoxy pyrimidyl-2-yl)ureido]methylpyrazolyl-4-carboxylic ester

DL-BUTHIONINE-[S,R]-SULFOXIMINE Suppliers

Global( 82)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49374	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569266 15319487004	1015@dideu.com	China	3940	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30237	58
Nextpeptide Inc	+86-0571-81612335 +8613336028439	sales@nextpeptide.com	China	19908	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49734	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38631	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+undefined18621343501	product@acmec-e.com	China	33338	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52924	58
SHANGHAI KEAN TECHNOLOGY CO., LTD.	+8613817748580	cooperation@kean-chem.com	China	40066	58

Supplier	Advantage
CONIER CHEM AND PHARMA LIMITED	58
Shaanxi Dideu Medichem Co. Ltd	58
TargetMol Chemicals Inc.	58
Career Henan Chemica Co	58
Nextpeptide Inc	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	58
TargetMol Chemicals Inc.	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58
Aladdin Scientific	58
SHANGHAI KEAN TECHNOLOGY CO., LTD.	58

View Lastest Price from DL-BUTHIONINE-[S,R]-SULFOXIMINE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-11-19	DL-Buthionine-(S,R)-sulfoximine 5072-26-4	US $30.00-43.00 / mg		98.32%	10g	TargetMol Chemicals Inc.

DL-Buthionine-(S,R)-sulfoximine
5072-26-4
US $30.00-43.00 / mg
98.32%
TargetMol Chemicals Inc.

DL-BUTHIONINE-[S,R]-SULFOXIMINE Spectrum

DL-BUTHIONINE-[S,R]-SULFOXIMINE(5072-26-4)IR

5072-26-4(DL-BUTHIONINE-[S,R]-SULFOXIMINE)Related Search:

1-Dodecanethiol 4-Methyl-2-pentanone D,L-BUTHIONINE 4-(TERT-BUTYL)BENZENE-1-CARBOTHIOAMIDE Butylate

Tetrabutylammonium hydrogen sulfate S-Butyrylthiocholine Iodide Terbufos TETRA-N-BUTYLTHIURAM DISULFIDE 1,3-Dibutyl-2-thiourea

N-BUTYLTHIOUREA 2-Methyl-2-propanethiol Dibutyl sulfide L-BUTHIONINE-(S,R)-SULFOXIMINE L-BUTHIONINE

FMOC-L-BUTHIONINESULFOXIMINE BOC-DL-BUTHIONINESULFOXIMINE FMOC-DL-BUTHIONINESULFOXIMINE

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DL-BUTHIONINE (R,S)-SULFOXIMINE DL-BUTHIONINE-[S,R]-SULFOXIMINE DL-BUTHIONINE (S,R)-SULPHOXIME DL-BUTHIONINE-SULFOXIMINE 2-amino-4-(s-butylsulfonimidoyl)-butanoicaci 2-amino-4-(s-butylsulfonimidoyl)butanoicacid buthioninesulfoxamine buthioninesulfoximine buthioninesulphoximine butioninesulfoximine s-(3-amino-3-carboxypropyl)-s-butyl-sulfoximin Butanoic acid, 2-amino-4-(S-butylsulfonimidoyl)-. NSC 381100 S-(3-Amino-3-carboxypropyl)-S-butylsulfoximine S-butyl-DL-homocysteine (S,R)-sulfoximine 2-Amino-4-(S-butylsulphonimidoyl)butanoic acid, S-(3-Amino-3-carboxypropyl)-S-butylsulphoximine DL-Buthionine (S,R)-sulfoxiMine, 99% 500MG 2-Amino-4-(S-butylsulfonimidoyl)butyric acid DL-Buthionine (S,R)-sulfoximine,99% D,L-Buthionine-(S,R)-sulfoximine (Synonyms: Butionine sulfoximine) D,L-Buthionine-(S,R)-sulfoximine (Butionine sulfoximine) 2-Amino-4-(butylsulfonimidoyl)butanoic acid BSO,DL Buthionine (S,R) sulfoximine,Buthionine sulfoximine,DLButhionine(S,R)sulfoximine,Inhibitor,inhibit,Ferroptosis D,L-Buthionine-(S,R)-sulfoximine, gamma-glutamyl cysteine synthase inhibitor 5072-26-4 C8H18N2O3S CH3CH23SONHCH2CH2CHNH2CO2H Biochemicals and Reagents BioChemical Fusarinine -C Ornithinesterase Enzyme Inhibitors by Enzyme Enzymes, Inhibitors, and Substrates Enzyme Inhibitors D to K Glutathione S-Transferase Agents Sulfur & Selenium Compounds D to Drug and Xenobiotic Metabolism Enzyme Inhibitors by Enzyme Fusarinine -C OrnithinesteraseMulti-Drug Resistance and Drug Metabolism Substrates, Inducers, Inhibitors