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N-[3,5-bis(trifluoromethyl)phenyl]-N-(1,1-dioxido-1,2-benzisothiazol-3-yl)amine

N-[3,5-bis(trifluoromethyl)phenyl]-N-(1,1-dioxido-1,2-benzisothiazol-3-yl)amine structure

CAS No.: 823830-85-9

Chemical Name:: N-[3,5-bis(trifluoromethyl)phenyl]-N-(1,1-dioxido-1,2-benzisothiazol-3-yl)amine

Synonyms: N-[3,5-bis(trifluoromethyl)phenyl]-1,2-benzothiazol-3-amine 1,1-dioxide;1,2-Benzisothiazol-3-amine, N-[3,5-bis(trifluoromethyl)phenyl]-, 1,1-dioxide;N-[3,5-bis(trifluoromethyl)phenyl]-N-(1,1-dioxido-1,2-benzisothiazol-3-yl)amine

CBNumber:: CB42008352

Molecular Formula:: C15H8F6N2O2S

Molecular Weight:: 394.29

MDL Number:

MOL File:: 823830-85-9.mol

Last updated:2024-07-02 08:55:08

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N-[3,5-bis(trifluoromethyl)phenyl]-N-(1,1-dioxido-1,2-benzisothiazol-3-yl)amine Properties

Boiling point	414.6±55.0 °C(Predicted)
Density	1.60±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
form	Solid
pka	-2.13±0.20(Predicted)
color	White to off-white

N-[3,5-bis(trifluoromethyl)phenyl]-N-(1,1-dioxido-1,2-benzisothiazol-3-yl)amine price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
DC Chemicals	013390	M1002	823830-85-9	002	$750	2021-12-16	Buy
DC Chemicals	013390	M1002	823830-85-9	003	$1200	2021-12-16	Buy
DC Chemicals	013390	M1002	823830-85-9	004	$2400	2021-12-16	Buy

Product number	Packaging	Price	Buy
013390	002	$750	Buy
013390	003	$1200	Buy
013390	004	$2400	Buy

N-[3,5-bis(trifluoromethyl)phenyl]-N-(1,1-dioxido-1,2-benzisothiazol-3-yl)amine Chemical Properties,Uses,Production

Biological Activity

M1002 is a hypoxia-inducible factor-2 (HIF-2) agonist, and can enhance the expression of HIF-2 target genes. M1002 shows synergy with prolyl-hydroxylase domain (PHD) inhibitors[1]. M1002 (10 μM; 24 h) enhances the expression of HIF-2 target genes with great efficacy[1].M1002 (5 μM; 24 h) treatment shows synergy with prolyl hydroxylase domain (PHD) inhibitors[1].

References

[1]. Dalei Wu, et al. Bidirectional modulation of HIF-2 activity through chemical ligands. Nat Chem Biol. 2019 Apr;15(4):367-376.

N-[3,5-bis(trifluoromethyl)phenyl]-N-(1,1-dioxido-1,2-benzisothiazol-3-yl)amine Preparation Products And Raw materials

Raw materials

Preparation Products

N-[3,5-bis(trifluoromethyl)phenyl]-N-(1,1-dioxido-1,2-benzisothiazol-3-yl)amine Suppliers

Global( 7)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9707	58
DC Chemicals	021-58447131 13564518121	sales@dcchemicals.com	China	9412	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	23963	58
Suzhou Zhixin Biotechnology Co., Ltd.	0512-65118909 15162312715	sales@szzxbio.com	China	3016	58
Nantong QuanYi Biotechnology Co., Ltd	0513-66337626 18051384581	sales@chemhifuture.com	China	4578	58

Supplier	Advantage
Shanghai EFE Biological Technology Co., Ltd.	58
DC Chemicals	58
TargetMol Chemicals Inc.	58
Suzhou Zhixin Biotechnology Co., Ltd.	58
Nantong QuanYi Biotechnology Co., Ltd	58

N-[3,5-bis(trifluoromethyl)phenyl]-N-(1,1-dioxido-1,2-benzisothiazol-3-yl)amine N-[3,5-bis(trifluoromethyl)phenyl]-1,2-benzothiazol-3-amine 1,1-dioxide 1,2-Benzisothiazol-3-amine, N-[3,5-bis(trifluoromethyl)phenyl]-, 1,1-dioxide 823830-85-9 C15H8F6N2O2S