Anti-GOK, Anti-Stromal interaction molecule 1
- CAS No.
- Chemical Name:
- Anti-GOK, Anti-Stromal interaction molecule 1
- Synonyms
- Anti-GOK, Anti-Stromal interaction molecule 1;Anti-STIM1 (C-terminal) antibody produced in rabbit
- CBNumber:
- CB42094472
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
Anti-GOK, Anti-Stromal interaction molecule 1 price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | S6197 | Anti-STIM1 (C-terminal) antibody produced in rabbit ~1?mg/mL, affinity isolated antibody, buffered aqueous solution | 100μL | $479 | 2023-06-20 | Buy | |
Sigma-Aldrich | S6197 | Anti-STIM1 (C-terminal) antibody produced in rabbit ~1?mg/mL, affinity isolated antibody, buffered aqueous solution | 200μL | $618 | 2023-06-20 | Buy |
Anti-GOK, Anti-Stromal interaction molecule 1 Chemical Properties,Uses,Production
Uses
Anti-STIM1 (C-terminal) antibody produced in rabbit has been used in:
- western blot
- immunoprecipitation
- immunofluorescence
- immunohistochemistry
General Description
Stromal interaction molecule 1 (STIM1) is a conserved single-pass transmembrane protein. STIM1 is expressed ubiquitously in a wide variety of human primary and transformed cell types. STIM1 localizes predominantly in the membrane of the endoplasmic reticulum (ER). It contains an N-terminal EF hand motif located in the ER lumen and appears to function as a sensor of ER Ca2+ levels.
Biochem/physiol Actions
Stromal interaction molecule 1 (STIM1) is required for the activation of store-operated Ca2+ influx. STIM1 undergoes rapid oligomerization and redistributes into discrete spots (punctae) that move towards and accumulate in the cell periphery, possibly to activate Orai1 that is located in the plasma membrane. Overexpression of STIM1 and Orai1 together markedly increases the calcium release-activated channels (CRAC) current (I-CRAC). Dynamic assembly of TRPC1-STIM1-Orai1 ternary complex plays a major role in the activation of store-operated calcium (SOC) channel in response to internal Ca2+ store depletion.
Anti-GOK, Anti-Stromal interaction molecule 1 Preparation Products And Raw materials
Raw materials
Preparation Products
Anti-GOK, Anti-Stromal interaction molecule 1 Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
Supplier | Advantage |
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Sigma-Aldrich | 80 |